Colonization dynamics of Streptococcus pneumoniae in a remote African population: A prospective cohort study

Autor: Arnaud Flamen, Mark van der Linden, Jonas Ehrhardt, Abraham Alabi, Frieder Schaumburg

Publikováno v: Vaccine. 38:5413-5417

The aim of this study was to analyze the population dynamics of Streptococcus pneumoniae in a remotely living African Pygmy population. The same pygmy population (Gabon) was prospectively screened for nasopharyngeal S. pneumoniae colonization in 2011

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc055281c98b63a6fd97c83a840cfc7
https://doi.org/10.1016/j.vaccine.2020.06.051

Complement 5a Receptor Polymorphisms Are Associated With Panton-Valentine Leukocidin-positive Staphylococcus aureus Colonization in African Pygmies

Autor: Georg Peters, Frieder Schaumburg, Arnaud Flamen, Bettina Löffler, Peter G. Kremsner, Anika Witten, Monika Stoll, Thirumalaisamy P. Velavan, Abraham Alabi, Peter F. Zipfel

Publikováno v: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 68(5)

Panton-Valentine leukocidin (PVL) is common in African Staphylococcus aureus and can be associated with skin and soft tissue infection. PVL-positive S. aureus colonization is associated with a variant of complement receptor 5a, the cellular target of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4436845e677c0966da381b70096dfac2
https://pubmed.ncbi.nlm.nih.gov/30192927

First Results of Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Children

Autor: Jahit Sacarlal, Agnes Akoth Onyango, Jackton Omoto, Portia Kamthunzi, Norbert Awino, Samuel Ayamba, Yolanda Guerra, Tisungane Mvalo, Diana Quelhas, Daniel Ansong, Didier Leboulleux, Béatrice Peggy Abossolo, Halidou Tinto, Dalitso Nyakuipa, Tsiri Agbenyega, Victorine Owira, Roma Chilengi, Kingsley Kayan, David Sambian, Terrell Carter, Ali Ali, Martha M. Lemnge, Cornelia Conzelmann, Seth Owusu-Agyei, Quique Bassat, Jean-Bosco Ouédraogo, William Kabore, José Francisco Fernandes, Chris Drakeley, Peter G. Kremsner, Afiya Radford, Saadou Issifou, Philip Bejon, Umberto D'Alessandro, Christian Loucq, Chris Odero, Francisca Machera, Pedro L. Alonso, Ali Mtoro, Theresa Rettig, John Lusingu, Albans Msika, Kwaku Poku Asante, Brian Greenwood, Alex Agyekum, George Adjei, Ruth Wasuna, Innocent Valea, Ali Hamad, Irving F. Hoffman, Rose Minja, Nelecy Chome, John Williamson, Charity Maingi, Salim Abdulla, Omar Juma, Amanda J. Leach, Stacey M. O. Gondi, W. Ripley Ballou, Mwanajaa Shomari, Johan Vekemans, Opokua Ofori-Anyinam, Hermann Sorgho, Samwel Gesase, Myriam Bruls, Allan Otieno, Barbara Gaelle Nfono Ondo Methogo, Kephas Otieno, David Dosoo, Benjamin Mordmüller, Walter Otieno, John J. Aponte, Yannick Doucka, Bertrand Lell, Didier Lapierre, Joe Cohen, Selidji T Agnandji, Coline Mahende, Alwisa Urassa, Lucas Otieno, Sofia Mandjate, David B. Jones, Samuel Adjei, Mary J. Hamel, Martina Oneko, Bernhards Ogutu, Hassan Kilavo, Marla Sillman, Isaac Asante, Ruth Owusu-Ofori, Preeti Vansadia, Laurence Slutsker, Sayouba Ouedraogo, John Bawa, Christine Kerubo, Omari Abdul, Pedro Aide, Justice Sylverken, Marcel Tanner, Barbara Savarese, David Schellenberg, Marc Christian Tahita, Norbert Peshu, Yara Sandrine, Owusu Boahen, Ruthendo Nkomo, Benjamin Tsofa, Kayla F. Laserson, Patricia Njuguna, Pauline Akoo, Joseph Chintedza, Grace Mwangoka, Miguel A. Lanaspa, Robert T. Guiguemdé, Erik Jongert, Allan Jumbe, Larko Owusu, Thor G. Theander, Alma Sykes, Francis Martinson, Edwin Liheluka, Eusebio Macete, Kingsley Osei-Kwakye, Marc Lievens, Saumu Ahmed, Nahya Salim, Otsyula Nekoye, Arlindo Nhamuave, Kafuruki Shubis, Kevin Marsh, Ally Olotu, Trudie Lang, Harry Owusu Boateng, Anangisye Malabeja, Arnaud Flamen, Simon Kariuki, Solange Soulanoudjingar, Jesse Gitaka, Vincent Muturi-Kioi, Daniel Chandramohan

Publikováno v: New England Journal of Medicine. 365:1863-1875

BACKGROUND An ongoing phase 3 study of the efficacy, safety, and immunogenicity of candidate malaria vaccine RTS,S/AS01 is being conducted in seven African countries. METHODS From March 2009 through January 2011, we enrolled 15,460 children in two ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c16dced5eb2fd8989f7492b258232d8
https://doi.org/10.1056/nejmoa1102287

Childhood tuberculosis in Lambaréné, Gabon: tuberculosis control in its infancy?

Autor: Arnaud Flamen, Sabine Bélard, S. Janssen, Martin P. Grobusch, Cosme Kokou

Publikováno v: Infection, 42(1), 161-164. Urban und Vogel

Central Africa is a region highly affected by the tuberculosis (TB) pandemic; however, data on local epidemiology are scarce. In the quest for gearing up towards tailored interventions, assessment of local baseline situations is mandatory. We conduct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5be8e6b792670511287ec7cf0d2ad66f
https://pure.amc.nl/en/publications/childhood-tuberculosis-in-lambarene-gabon-tuberculosis-control-in-its-infancy(75d520d2-22a6-4ad4-960c-2a4f8e669c95).html

Methaemoglobin and COHb in patients with malaria

Autor: Arnaud Flamen, Tom M Gresnigt, Martin P. Grobusch, Thomas Hänscheid, Thomas Zoller, José Melo-Cristino, Sascha J Z Löhr

Publikováno v: Malaria Journal
Malaria journal, 13(1). BioMed Central

Background Haemolytic conditions may contribute to disease pathogenesis and severe clinical manifestations through the liberation of free haemoglobin (Hb) and production of toxic free haem. Thus, free Hb and haem should be associated with altered Met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f560aab3ff46454f0bace3e9e3e25c6e