Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Arnaud Duchon"'
Autor:
Chiara Lanzillotta, Monika Rataj Baniowska, Francesca Prestia, Chiara Sette, Valérie Nalesso, Marzia Perluigi, Eugenio Barone, Arnaud Duchon, Antonella Tramutola, Yann Herault, Fabio Di Domenico
Publikováno v:
Neurobiology of Disease, Vol 196, Iss , Pp 106523- (2024)
Down syndrome (DS) is the most common condition with intellectual disability and is caused by trisomy of Homo sapiens chromosome 21 (HSA21). The increased dosage of genes on HSA21 is associated with early neurodevelopmental changes and subsequently a
Externí odkaz:
https://doaj.org/article/8bbfa0072b10423083ac0ef41345ec37
Autor:
Arnaud Duchon, Maria del Mar Muñiz Moreno, Claire Chevalier, Valérie Nalesso, Philippe Andre, Marta Fructuoso-Castellar, Mary Mondino, Chrystelle Po, Vincent Noblet, Marie-Christine Birling, Marie-Claude Potier, Yann Herault
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 12 (2022)
Externí odkaz:
https://doaj.org/article/b9c8301d72d34dcea16c3c22b66ed21f
Autor:
Ekaterina L. Ivanova, Johan G. Gilet, Vadym Sulimenko, Arnaud Duchon, Gabrielle Rudolf, Karen Runge, Stephan C. Collins, Laure Asselin, Loic Broix, Nathalie Drouot, Peggy Tilly, Patrick Nusbaum, Alexandre Vincent, William Magnant, Valerie Skory, Marie-Christine Birling, Guillaume Pavlovic, Juliette D. Godin, Binnaz Yalcin, Yann Hérault, Pavel Dráber, Jamel Chelly, Maria-Victoria Hinckelmann
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
New mutations and genes associated with malformations of cortical development keep being identified, yet there is little known about the underlying cellular mechanisms controlling these impairments. Here, authors generate and characterize a heterozyg
Externí odkaz:
https://doaj.org/article/70b73ea35c47483e83ff67156a41b716
Autor:
Thu Lan Nguyen, Arnaud Duchon, Antigoni Manousopoulou, Nadège Loaëc, Benoît Villiers, Guillaume Pani, Meltem Karatas, Anna E. Mechling, Laura-Adela Harsan, Emmanuelle Limanton, Jean-Pierre Bazureau, François Carreaux, Spiros D. Garbis, Laurent Meijer, Yann Herault
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 9 (2018)
Growing evidence supports the implication of DYRK1A in the development of cognitive deficits seen in Down syndrome (DS) and Alzheimer's disease (AD). We here demonstrate that pharmacological inhibition of brain DYRK1A is able to correct recognition m
Externí odkaz:
https://doaj.org/article/e16e12f9d89c402a95c465eec377aa80
Autor:
Thomas Arbogast, Matthieu Raveau, Claire Chevalier, Valérie Nalesso, Doulaye Dembele, Hugues Jacobs, Olivia Wendling, Michel Roux, Arnaud Duchon, Yann Herault
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 6, Pp 623-634 (2015)
Partial monosomy 21 (PM21) is a rare chromosomal abnormality that is characterized by the loss of a variable segment along human chromosome 21 (Hsa21). The clinical phenotypes of this loss are heterogeneous and range from mild alterations to lethal c
Externí odkaz:
https://doaj.org/article/0c555f6364e54f5bb3de522f49323af9
Autor:
Benoit Souchet, Fayçal Guedj, Ignasi Sahún, Arnaud Duchon, Fabrice Daubigney, Anne Badel, Yuchio Yanagawa, Maria Jose Barallobre, Mara Dierssen, Eugene Yu, Yann Herault, Mariona Arbones, Nathalie Janel, Nicole Créau, Jean Maurice Delabar
Publikováno v:
Neurobiology of Disease, Vol 69, Iss , Pp 65-75 (2014)
Cognitive deficits in Down syndrome (DS) have been linked to increased synaptic inhibition, leading to an imbalance of excitation/inhibition (E/I). Various mouse models and studies from human brains have implicated an HSA21 gene, the serine/threonine
Externí odkaz:
https://doaj.org/article/38eb53d8da744590b164b4cc0d3230c4
Autor:
Véronique Brault, Arnaud Duchon, Caroline Romestaing, Ignasi Sahun, Stéphanie Pothion, Mona Karout, Christelle Borel, Doulaye Dembele, Jean-Charles Bizot, Nadia Messaddeq, Andrew J Sharp, Damien Roussel, Stylianos E Antonarakis, Mara Dierssen, Yann Hérault
Publikováno v:
PLoS Genetics, Vol 11, Iss 3, p e1005062 (2015)
The trisomy of human chromosome 21 (Hsa21), which causes Down syndrome (DS), is the most common viable human aneuploidy. In contrast to trisomy, the complete monosomy (M21) of Hsa21 is lethal, and only partial monosomy or mosaic monosomy of Hsa21 is
Externí odkaz:
https://doaj.org/article/b40c51e2932f4ffab25edd46f6fc0748
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0115302 (2015)
Down syndrome (DS) results from one extra copy of human chromosome 21 and leads to several alterations including intellectual disabilities and locomotor defects. The transchromosomic Tc1 mouse model carrying an extra freely-segregating copy of human
Externí odkaz:
https://doaj.org/article/08459fbdab0f4fdc90b5817c9d670e94
Autor:
Matthieu Raveau, Jacques M Lignon, Valérie Nalesso, Arnaud Duchon, Yoram Groner, Andrew J Sharp, Doulaye Dembele, Véronique Brault, Yann Hérault
Publikováno v:
PLoS Genetics, Vol 8, Iss 5, p e1002724 (2012)
Down syndrome (DS) leads to complex phenotypes and is the main genetic cause of birth defects and heart diseases. The Ts65Dn DS mouse model is trisomic for the distal part of mouse chromosome 16 and displays similar features with post-natal lethality
Externí odkaz:
https://doaj.org/article/51f56e59e5ff439ba64d46c309343654
Autor:
Christophe Noll, Chris Planque, Clémentine Ripoll, Fayçal Guedj, Anna Diez, Véronique Ducros, Nicole Belin, Arnaud Duchon, Jean-Louis Paul, Anne Badel, Bénédicte de Freminville, Yann Grattau, Henri Bléhaut, Yann Herault, Nathalie Janel, Jean-Maurice Delabar
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7540 (2009)
BACKGROUND:Hyperhomocysteinemia, characterized by increased plasma homocysteine level, is associated with an increased risk of atherosclerosis. On the contrary, patients with Down syndrome appear to be protected from the development of atherosclerosi
Externí odkaz:
https://doaj.org/article/a94d4700836043619d53e9078d9d582e