Comparative pharmacokinetics, biodistribution, metabolism and hypoxia-dependent uptake of [18F]-EF3 and [18F]-MISO in rodent tumor models

Autor: Pierre Mahy, Vincent Grégoire, Daniel Labar, Marc De Bast, J. Gillart, Karin Haustermans, Arnaud Cheguillaume, Tjibbe de Groot

Publikováno v: Radiotherapy and Oncology. 89:353-360

BACKGROUND AND PURPOSE: [(18)F]-EF3 allows non-invasive detection of hypoxia. In the framework of its validation, we aimed at comparing its pharmacokinetics, biodistribution, metabolism and specificity for hypoxia with the hypoxia tracer [(18)F]-FMIS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71fad8fc3c0c00279c8ef7aa99fe378e
https://doi.org/10.1016/j.radonc.2008.06.008

Synthesis of N -Protected 3,3-Difluoroazetidin-2-ones

Autor: Arnaud Cheguillaume, Jacqueline Marchand-Brynaert, Simon Lacroix, Stéphane Gérard

Publikováno v: Synthesis. :2483-2486

Representative N-protected 3,3-difluoroazetidin-2-ones 3 were obtained, either in one step by cycloaddition of zinc enolate 1 derived from ethyl bromodifluoroacetate onto N,N',N"-trisubstituted hexahydro-1,3,5-triazines 2 (Schiff base trimer) in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b199adae1fd9134a1bdc3309acfb78c
https://doi.org/10.1055/s-2003-42415

A practical synthesis of 2,2-difluoro-3-amino-propanoic acid (α,α-difluoro-β-alanine)

Autor: Simon Lacroix, Arnaud Cheguillaume, Jacqueline Marchand-Brynaert

Publikováno v: Tetrahedron Letters. 44:2375-2377

Reformatsky reaction of ethyl bromodifluoroacetate with N,N-(dibenzyl)-1H-benzotriazolyl-1-methylamine gave fully protected alpha,alpha-difluoro-beta-alanine. Hydrogenolysis and hydrolysis furnished alpha,alpha-difluoro-beta-alanine. Further transfor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68908ff1fb22a9557f9e18dcb2cd4397
https://doi.org/10.1016/s0040-4039(03)00243-0

ChemInform Abstract: New Potential Monomers for Solid Phase Synthesis of Hydrazinopeptoids: The Nα-Substituted-Nβ-Protected Hydrazinoglycines and Hydrazinoglycinals

Autor: Ismahel Doubli-Bounoua, Michèle Baudy-Floc’h, Philippe Le Grel, Arnaud Cheguillaume

Publikováno v: ChemInform. 31

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6130c4074e45bac5745eb856f603afc
https://doi.org/10.1002/chin.200025076

Solid-phase synthesis of 'mixed' peptidomimetics using Fmoc-protected aza-beta3-amino acids and alpha-amino acids

Autor: Hayet Dali, Michèle Baudy-Floc’h, Arnaud Bondon, Soizic Chevance, Sylviane Muller, Arnaud Cheguillaume, Lanrong Bi, Olivier Busnel

Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 2005, 70 (26), pp.10701-8. ⟨10.1021/jo051585o⟩
Journal of Organic Chemistry, 2005, 70 (26), pp.10701-8. ⟨10.1021/jo051585o⟩

International audience; [structure: see text] A solid-phase fluorenylmethyloxycarbonyl (Fmoc)-based synthesis strategy is described for "mixed" aza-beta3-peptides as well as a convenient general approach for their required building blocks, the aza-be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158b43d542c95ce1bbe97f9b4459df2f
https://hal.archives-ouvertes.fr/hal-00941958