Výsledky vyhledávání - "Arnaud Bruyère"

Akademický článek

Interactions of organophosphate flame retardants with human drug transporters

Autor: Valentin Tastet, Marc Le Vée, Marie Kerhoas, Anna Zerdoug, Elodie Jouan, Arnaud Bruyère, Olivier Fardel

Publikováno v: Ecotoxicology and Environmental Safety, Vol 263, Iss , Pp 115348- (2023)

Organophosphate flame retardants (OPFRs) are environmental pollutants of increasing interest, widely distributed in the environment and exerting possible deleterious effects towards the human health. The present study investigates in vitro their poss

Externí odkaz: https://doaj.org/article/3f0cd1b2c257427e9b55b3e02e28499a

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Akademický článek

Generation of proliferating human adult hepatocytes using optimized 3D culture conditions

Autor: Sophie Rose, Frédéric Ezan, Marie Cuvellier, Arnaud Bruyère, Vincent Legagneux, Sophie Langouët, Georges Baffet

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)

Abstract Generating the proliferation of differentiated normal adult human hepatocytes is a major challenge and an expected central step in understanding the microenvironmental conditions that regulate the phenotype of human hepatocytes in vitro. In

Externí odkaz: https://doaj.org/article/5698f8c84c2c4af488edf5e3538a8768

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Interactions of human drug transporters with chemical additives present in plastics: Potential consequences for toxicokinetics and health

Autor: Valentin Tastet, Marc Le Vée, Arnaud Bruyère, Olivier Fardel

Publikováno v: Environmental Pollution
Environmental Pollution, 2023, 331 (Pt 2), pp.121882. ⟨10.1016/j.envpol.2023.121882⟩

International audience; Human membrane drug transporters are recognized as major actors of pharmacokinetics; they also handle endogenous compounds, including hormones and metabolites. Chemical additives present in plastics interact with human drug tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fdf64c4e888ef90cf4ebca8f2e929b2
https://hal.science/hal-04121151

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Differential Inhibition of Equilibrative Nucleoside Transporter 1 (ENT1) Activity by Tyrosine Kinase Inhibitors

Autor: Claire Denizot, Karima Alim, Amélie Moreau, Olivier Fardel, Yannick Parmentier, Elodie Jouan, Arnaud Bruyère

Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics
European journal of drug metabolism and pharmacokinetics
European journal of drug metabolism and pharmacokinetics, Springer, 2021, 46 (5), pp.625-635. ⟨10.1007/s13318-021-00703-2⟩
European journal of drug metabolism and pharmacokinetics, 2021, 46 (5), pp.625-635. ⟨10.1007/s13318-021-00703-2⟩

International audience; Background and Objectives Equilibrative nucleoside transporter (ENT) 1 is a widely-expressed drug transporter, handling nucleoside analogues as well as endogenous nucleosides. ENT1 has been postulated to be inhibited by some m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::535a074bd5d0488c39d3fd8644352eaf
http://europepmc.org/articles/PMC8286641

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Differential interactions of carbamate pesticides with drug transporters

Autor: Antoine Huguet, Ludovic Le Hégarat, Olivier Fardel, Mélanie Ringeval, Nelly Guéniche, Elodie Jouan, Arnaud Bruyère

Publikováno v: Xenobiotica
Xenobiotica, 2020, 50 (11), pp.1380-1392. ⟨10.1080/00498254.2020.1771473⟩
Xenobiotica, Taylor & Francis, 2020, 50 (11), pp.1380-1392. ⟨10.1080/00498254.2020.1771473⟩

International audience; Pesticides are now recognised to interact with drug transporters, but only few data are available on this issue for carbamate pesticides, a widely-used class of agrochemicals, to which humans are highly exposed. The present st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::981b27435e6956d14646b49330d8932d
https://doi.org/10.1080/00498254.2020.1771473

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In vitro long term differentiation and functionality of three-dimensional bioprinted primary human hepatocytes: application for in vivo engraftment

Autor: Marie Cuvellier, Sophie Rose, Frédéric Ezan, Ulrich Jarry, Hugo de Oliveira, Arnaud Bruyère, Christophe Drieu La Rochelle, Vincent Legagneux, Sophie Langouët, Georges Baffet

Publikováno v: Biofabrication
Biofabrication, 2022, 14 (3), pp.035021. ⟨10.1088/1758-5090/ac7825⟩

In recent decades, 3D in vitro cultures of primary human hepatocytes (PHHs) have been increasingly developed to establish models capable of faithfully mimicking main liver functions. The use of 3D bioprinting, capable of recreating structures compose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24696cb58c3e4a1bfd25c326486c066
https://univ-rennes.hal.science/hal-03710469/document

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Drivers of absolute systemic bioavailability after oral pulmonary inhalation in humans

Autor: Pascal Le Corre, Guillaume Bouzillé, Astrid Bacle, Marc Cuggia, Olivier Fardel, Arnaud Bruyère

Publikováno v: European Journal of Pharmaceutics and Biopharmaceutics
European Journal of Pharmaceutics and Biopharmaceutics, 2021, 164, pp.36-53. ⟨10.1016/j.ejpb.2021.04.014⟩
European Journal of Pharmaceutics and Biopharmaceutics, Elsevier, 2021, 164, pp.36-53. ⟨10.1016/j.ejpb.2021.04.014⟩

International audience; There are few studies in humans dealing with the relationship between physico-chemical properties of drugs and their systemic bioavailability after administration via oral inhalation route (Fpulm). Getting further insight in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81bc8dcb37da030f6a1dd7da3db63e75
https://hal.science/hal-03222648/document

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P124. An association of Curcuma and Scutellaria plant extracts protects against inflammation induced by LPS in intestinal porcine epithelial cells

Autor: Delphine Gardan-Salmon, Stéphanie Molez, Vincent Bégos, Marisela Arturo-Schaan, Arnaud Bruyère

Publikováno v: Animal - science proceedings. 13:195

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97965c3bae5697d06b8dcfd166c023f6
https://doi.org/10.1016/j.anscip.2022.03.327

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Inhibition of organic cation transporter 3 activity by tyrosine kinase inhibitors

Autor: Anne T. Nies, Karima Alim, Elodie Jouan, Arnaud Bruyère, Amélie Moreau, Olivier Fardel, Yannick Parmentier, Claire Denizot

Publikováno v: Fundamental & Clinical Pharmacology
Fundamental & Clinical Pharmacology, 2021, ⟨10.1111/fcp.12657⟩
Fundamental and Clinical Pharmacology
Fundamental and Clinical Pharmacology, Wiley, 2021, ⟨10.1111/fcp.12657⟩

International audience; Organic cation transporter (OCT) 3 (SLC22A3) is a widely-expressed drug transporter, handling notably metformin and platinum derivatives, as well as endogenous compounds like monoamine neurotransmitters. OCT3 has been shown to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94fd25b777376f878e4ebcd7c3dba866
https://hal.science/hal-03134613

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Differential

Autor: Arnaud, Bruyère, Marc, Le Vée, Elodie, Jouan, Stephanie, Molez, Anne T, Nies, Olivier, Fardel

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 51(4)

Interactions of the Janus kinase (JAK) inhibitor ruxolitinib with solute carriers (SLCs) remain incompletely characterised. The present study was therefore designed to investigate this issue.The interactions of ruxolitinib with SLCs were analysed usi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b73498641f31faaa7236a7706a632dca
https://pubmed.ncbi.nlm.nih.gov/33455503

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