Zobrazeno 1 - 10 of 77 pro vyhledávání: '"Arnaud, Nicot"'
1
Multiple Sclerosis CSF Is Enriched With Follicular T Cells Displaying a Th1/Eomes Signature
Autor: Jérémy, Morille, Marion, Mandon, Stéphane, Rodriguez, David, Roulois, Simon, Leonard, Alexandra, Garcia, Sandrine, Wiertlewski, Emmanuelle, Le Page, Laureline, Berthelot, Arnaud, Nicot, Camille, Mathé, Flora, Lejeune, Karin, Tarte, Céline, Delaloy, Patricia, Amé, David, Laplaud, Laure, Michel
Publikováno v: Neurology Neuroimmunology & Neuroinflammation
Neurology Neuroimmunology & Neuroinflammation, 2022, 9 (6), pp.e200033. ⟨10.1212/NXI.0000000000200033⟩
International audience; Background and Objectives Tertiary lymphoid structures and aggregates are reported in the meninges of patients with multiple sclerosis (MS), especially at the progressive stage, and are strongly associated with cortical lesion
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ac2383f07cc41253fda230dda378c317
https://hal.science/hal-03882660
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2
Akademický článek
Pro-inflammatory State in Monoclonal Gammopathy of Undetermined Significance and in Multiple Myeloma Is Characterized by Low Sialylation of Pathogen-Specific and Other Monoclonal Immunoglobulins
Autor: Adrien Bosseboeuf, Sophie Allain-Maillet, Nicolas Mennesson, Anne Tallet, Cédric Rossi, Laurent Garderet, Denis Caillot, Philippe Moreau, Eric Piver, François Girodon, Hélène Perreault, Sophie Brouard, Arnaud Nicot, Edith Bigot-Corbel, Sylvie Hermouet, Jean Harb
Publikováno v: Frontiers in Immunology, Vol 8 (2017)
Multiple myeloma (MM) and its pre-cancerous stage monoclonal gammopathy of undetermined significance (MGUS) allow to study immune responses and the chronology of inflammation in the context of blood malignancies. Both diseases are characterized by th
Externí odkaz: https://doaj.org/article/0ba3d12163654fd4a6bb0491adb170f7
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3
Preclinical model for the study of immune responses specific for a hepatic self-antigen
Autor: Anaïs Cardon, Jean-Paul Judor, Thomas Guinebretière, Richard Danger, Arnaud Nicot, Sophie Brouard, Sophie Conchon, Amédée Renand
The liver displays a strong capacity to induce tolerance toward hepatic antigens. However, hepatic tolerance can be overcome with the development of local autoimmune diseases such as autoimmune hepatitis (AIH). This chronic inflammatory disorder lead
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d3777040727e36d7906bc43daefa396
https://doi.org/10.1101/2022.06.22.497185
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4
Immune Profiling Reveals the T-Cell Effect of Ocrelizumab in Early Relapsing-Remitting Multiple Sclerosis
Autor: Alexandra Garcia, Emilie Dugast, Sita Shah, Jérémy Morille, Christine Lebrun-Frenay, Eric Thouvenot, Jérôme De Sèze, Emmanuelle Le Page, Sandra Vukusic, Aude Maurousset, Eric Berger, Olivier Casez, Pierre Labauge, Aurélie Ruet, Catarina Raposo, Fabien Bakdache, Régine Buffels, Fabienne Le Frère, Arnaud Nicot, Sandrine Wiertlewski, Pierre-Antoine Gourraud, Laureline Berthelot, David Laplaud
Publikováno v: Neurology Neuroimmunology & Neuroinflammation
Neurology Neuroimmunology & Neuroinflammation, 2023, 10 (3), pp.e200091. ⟨10.1212/NXI.0000000000200091⟩
Background and ObjectivesOcrelizumab (OCR), a humanized anti-CD20 monoclonal antibody, is highly efficient in patients with relapsing-remitting multiple sclerosis (RR-MS). We assessed early cellular immune profiles and their association with disease
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc1d798b10a68a099da6e914a7f048c8
https://doi.org/10.1212/nxi.0000000000200091
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5
Akademický článek
Decreased Frequency of Circulating Myelin Oligodendrocyte Glycoprotein B Lymphocytes in Patients with Relapsing-Remitting Multiple Sclerosis
Autor: Annie Elong Ngono, Maud Lepetit, Markus Reindl, Alexandra Garcia, Flora Guillot, Athénaïs Genty, Mélanie Chesneau, Marion Salou, Laure Michel, Fabienne Lefrere, Kathrin Schanda, Berthe-Marie Imbert-Marcille, Nicolas Degauque, Arnaud Nicot, Sophie Brouard, David-Axel Laplaud, Jean-Paul Soulillou
Publikováno v: Journal of Immunology Research, Vol 2015 (2015)
Although there is no evidence for a role of anti-MOG antibodies in adult MS, no information on B lymphocytes with MOG-committed BCR is available. We report here on the frequency of anti-MOG B cells forming rosettes with polystyrene beads (BBR) covale
Externí odkaz: https://doaj.org/article/6ae697d266744128b8d799aebc99bf4b
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6
Insights into the substrate binding mechanism of SULT1A1 through molecular dynamics with excited normal modes simulations
Autor: Maria A. Miteva, Erika Balog, David Perahia, Dániel J. Tóth, Balint Dudas, Arnaud Nicot
Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Sulfotransferases (SULTs) are phase II drug-metabolizing enzymes catalyzing the sulfoconjugation from the co-factor 3′-phosphoadenosine 5′-phosphosulfate (PAPS) to a substrate. It has been previously suggested that a considerable shift of SULT st
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae77d4624bb8eff13dbc10be1400c8f8
https://pubmed.ncbi.nlm.nih.gov/34162941
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7
Computational Analysis of Chemical Space of Natural Compounds Interacting with Sulfotransferases
Autor: Dessislava Jereva, Arnaud Nicot, Ilza Pajeva, Maria A. Miteva, Nathalie Lagarde, Yunhui Peng, Iglika Lessigiarska, Tania Pencheva, Petko Alov, Bruno O. Villoutreix, Ivanka Tsakovska
Publikováno v: Molecules
Molecules, MDPI, 2021, 26 (21), pp.6360. ⟨10.3390/molecules26216360⟩
Molecules, Vol 26, Iss 6360, p 6360 (2021)
Volume 26
Issue 21
International audience; The aim of this study was to investigate the chemical space and interactions of natural compounds with sulfotransferases (SULTs) using ligand- and structure-based in silico methods. An in-house library of natural ligands (horm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50e392a1d6d3096f4588d477b51fe94a
https://hal-cnam.archives-ouvertes.fr/hal-03448343/file/molecules-26-06360.pdf
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8
Akademický článek
Characterization of antigen-specific B cells using nominal antigen-coated flow-beads.
Autor: Nicolas Degauque, Annie Elong Ngono, Ahmed Akl, Maud Lepetit, Romain Crochette, Magali Giral, Julie Lepourry, Annaick Pallier, Stéphanie Castagnet, Emilie Dugast, Cécile Guillot-Gueguen, Marylène Jacq-Foucher, Xavier Saulquin, Anne Cesbron, David Laplaud, Arnaud Nicot, Sophie Brouard, Jean-Paul Soulillou
Publikováno v: PLoS ONE, Vol 8, Iss 12, p e84273 (2013)
In order to characterize the reactivity of B cells against nominal antigens, a method based on the coupling of antigens onto the surface of fluorescent core polystyrene beads was developed. We first demonstrate that murine B cells with a human MOG-sp
Externí odkaz: https://doaj.org/article/5e904cd88c8449959b379d301b015326
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9
An intermediate level of CD161 expression defines a novel activated, inflammatory, and pathogenic subset of CD8 + T cells involved in multiple sclerosis
Autor: J. Morille, Isabel Vogel, Laureline Berthelot, Sandrine Wiertlewski, Steven Nedellec, Stéphanie Kilens, Nicolas Degauque, Arnaud Bourreille, Emilie Dugast, Alexandra Garcia, Arnaud Nicot, Marion Salou, Laurent David, Fabienne Le Frère, Marylène Jacq-Foucher, David-Axel Laplaud, Eric Charpentier, Sophie Brouard, Audrey Donnart, Bryan Nicol, Pierre-Antoine Gourraud, Laure Michel
Publikováno v: Journal of Autoimmunity
Journal of Autoimmunity, Elsevier, 2018, GENOBIRD, 88, pp.61-74. ⟨10.1016/j.jaut.2017.10.005⟩
Journal of Autoimmunity, 2018, GENOBIRD, 88, pp.61-74. ⟨10.1016/j.jaut.2017.10.005⟩
International audience; Several lines of evidence support a key role for CD8+ T cells in central nervous system tissue damage of patients with multiple sclerosis. However, the precise phenotype of the circulating CD8+ T cells that may be recruited fr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f9cf069905db837dbc1fb6c0855b8f
https://doi.org/10.1016/j.jaut.2017.10.005
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10
Rabbit antithymocyte globulin–induced serum sickness disease and human kidney graft survival
Autor: Gwénaëlle Evanno, Arnaud Nicot, Ludmilla Le Berre, Yohann Foucher, Stéphanie Castagnet, Jean Harb, Pavel Vesely, Sophie Brouard, Ondrej Viklicky, Juliette Rousse, Evelyn Ang, Apolline Salama, Magali Giral, Jean-Marie Bach, Hélène Perreault, Thomas Dejoie, Béatrice Charreau, Petra Hruba, Pierrick Guerif, Grégoire Couvrat-Desvergnes, Jean-Paul Soulillou, Marine Lorent
Publikováno v: Journal of Clinical Investigation
Journal of Clinical Investigation, 2015, 125 (12), pp.4655-4665. ⟨10.1172/JCI82267⟩
Journal of Clinical Investigation, American Society for Clinical Investigation, 2015, 125 (12), pp.4655-4665. ⟨10.1172/JCI82267⟩
Journal of Clinical Investigation 12 (125), 4655-4665. (2015)
Grégoire Couvrat-Desvergnes, Apolline Salama, and Ludmilla Le Berre contributed equally to this work.; International audience; BACKGROUND: Rabbit-generated antithymocyte globulins (ATGs), which target human T cells, are widely used as immunosuppress
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d3eeb5041a9f67f031cb252348635c
https://doi.org/10.1172/jci82267
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