Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Arnaldo H. de Souza"'
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Akademický článek
NNT reverse mode of operation mediates glucose control of mitochondrial NADPH and glutathione redox state in mouse pancreatic β-cells
Autor: Laila R.B. Santos, Carole Muller, Arnaldo H. de Souza, Hilton K. Takahashi, Peter Spégel, Ian R. Sweet, Heeyoung Chae, Hindrik Mulder, Jean-Christophe Jonas
Publikováno v: Molecular Metabolism, Vol 6, Iss 6, Pp 535-547 (2017)
Objective: The glucose stimulation of insulin secretion (GSIS) by pancreatic β-cells critically depends on increased production of metabolic coupling factors, including NADPH. Nicotinamide nucleotide transhydrogenase (NNT) typically produces NADPH a
Externí odkaz: https://doaj.org/article/0f04113a4cbf41f3a84ac5709ef3102d
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2
Cholecystokinin attenuates β-cell apoptosis in both mouse and human islets
Autor: Mieke Baan, Steven J. Sacotte, Joseph T. Blumer, Jee Young Han, Heidi M. Umhoefer, Lucille E. Anzia, Rashaun A. Williams, Danielle A. Fontaine, Arnaldo H. de Souza, Carly R. Kibbe, Dawn Belt Davis, Jacob T. Bartosiak, Hung Tae Kim
Publikováno v: Transl Res
Loss of functional pancreatic β-cell mass and increased β-cell apoptosis are fundamental to the pathophysiology of type 1 and type 2 diabetes. Pancreatic islet transplantation has the potential to cure type 1 diabetes but is often ineffective due t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a596c37f694ba992d718780a2af3a61
https://doi.org/10.1016/j.trsl.2021.10.005
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3
Pancreatic Stellate Cells Prolong Ex Vivo Islet Viability and Function and Improve Engraftment
Autor: Pradyut K Paul, Rahul Das, Travis J Drow, Arnaldo H de Souza, Appakalai N Balamurugan, Dawn Belt Davis, Jacques Galipeau
Publikováno v: Stem Cells Translational Medicine. 11:630-643
Preserving islet health and function is critical during pretransplant culture to improve islet transplantation outcome and for ex vivo modeling of diabetes for pharmaceutical drug discovery. The limited islet engraftment potential is primarily attrib
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f2ca71f1ec356d55b40624b75d6f725
https://doi.org/10.1093/stcltm/szac018
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5
Intra-islet GLP-1, but not CCK, is necessary for β-cell function in mouse and human islets
Autor: Jiayin Tang, Matthew J. Merrins, Carly R. Kibbe, Dawn Belt Davis, Arnaldo H. de Souza, Samuel T. Saghafi, Amanjot Kaur Yadev, Amelia K. Linnemann
Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Glucagon-like peptide 1 (GLP-1) and cholecystokinin (CCK) are gut-derived peptide hormones known to play important roles in the regulation of gastrointestinal motility and secretion, appetite, and food intake. We have previously demonstrated that bot
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a74e72a03293d0283eceb9fbb7105c9
http://link.springer.com/article/10.1038/s41598-020-59799-2
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7
NNT reverse mode of operation mediates glucose control of mitochondrial NADPH and glutathione redox state in mouse pancreatic β-cells
Autor: Ian R. Sweet, Hindrik Mulder, Jean-Christophe Jonas, Peter Spégel, Heeyoung Chae, Carole Muller, Arnaldo H. de Souza, Laila Romagueira Bichara dos Santos, Hilton Kenji Takahashi
Publikováno v: Molecular Metabolism, Vol. 6, no. 6, p. 535-547 (2017)
Molecular Metabolism, Vol 6, Iss 6, Pp 535-547 (2017)
Molecular Metabolism
Objective: The glucose stimulation of insulin secretion (GSIS) by pancreatic β-cells critically depends on increased production of metabolic coupling factors, including NADPH. Nicotinamide nucleotide transhydrogenase (NNT) typically produces NADPH a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c758fdf0926d9dd70b439b45b682dd7
https://doi.org/10.1016/j.molmet.2017.04.004
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8
NADPH oxidase-2 does not contribute to β-cell glucotoxicity in cultured pancreatic islets from C57BL/6J mice
Autor: Arnaldo H. de Souza, Leticia Prates Roma, Laila Romagueira Bichara dos Santos, Jean-Christophe Jonas, Angelo Rafael Carpinelli, Mohammed Bensellam
Publikováno v: Molecular and Cellular Endocrinology, Vol. 439, p. 354-362 (2017)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
High glucose-induced oxidative stress and increased NADPH oxidase-2 (NOX2) activity may contribute to the progressive decline of the functional β-cell mass in type 2 diabetes. To test that hypothesis, we characterized, in islets from male NOX2 knock
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::613c3681023f84887ce0cf4a8184bd81
https://doi.org/10.1016/j.mce.2016.09.022
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9
2137-P: Cholecystokinin Protects Mouse Pancreatic Beta Cells against Cytokine Insult through the Cholecystokinin A Receptor
Autor: Jacob T. Bartosiak, Jee Young Han, Grace H. Yang, Dawn Belt Davis, Arnaldo H. de Souza, Hung Tae Kim, Rashaun A. Williams, Steve Sacotte
Publikováno v: Diabetes. 68
Cholecystokinin (CCK) is an incretin-like hormone that is also produced by pancreatic β-cells under conditions of stress and obesity. In the past, we have established a role for CCK in protection from β-cell apoptosis. However, the specific CCK rec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3991955a7fe61ce01e050534329a002
https://doi.org/10.2337/db19-2137-p
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