Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Arna Andrews"'
Autor:
Anton Zalewski, Arna Andrews, Isabelle Glauser, Marcel Mischnik, Matthew P. Hardy, Anne M Verhagen, Kerstin Emmrich, Sabine Pestel, Con Panousis, Philipp Claar, Victor Turnbull, Chao-Guang Chen, Michael J. Wilson, Gregory T. Bass, Elmar Raquet, Steve K. Dower, Jenny Chia, Thomas Weimer, Vesna Tomasetig
Publikováno v:
Journal of Thrombosis and Haemostasis. 19:2710-2725
BACKGROUND We have recently reported on a recombinant von Willebrand factor (VWF) D'D3 albumin fusion protein (rD'D3-FP) developed to extend the half-life of coagulation factor VIII (FVIII) for the treatment of hemophilia A. Based on predictive model
Autor:
Matthew P. Hardy, Katherine Monaghan, Vicki Sorto, Kirsten Edwards, Steven Rakar, Huy Huynh, Andrew D. Nash, Arna Andrews, Danijela Mirosa, Nicholas J. Wilson, Karen Scalzo-Inguanti, Samantha J. Busfield, Daria Kurtov, Hal Braley, Eva Herzog
Publikováno v:
Journal of Leukocyte Biology. 102:537-549
Neutrophils are the most abundant WBCs and have an essential role in the clearance of pathogens. Tight regulation of neutrophil numbers and their recruitment to sites of inflammation is critical in maintaining a balanced immune response. In various i
Autor:
Charley Mackenzie-Kludas, Brent S. McKenzie, Kirsten Edwards, Ian K. Campbell, Lorena E. Brown, Michael J. Wilson, Gabrielle L. Goldberg, Con Panousis, Karen Scalzo-Inguanti, Milica Ng, Veronika Rayzman, Ian P. Wicks, Nicholas J. Wilson, Adriana Baz Morelli, Kate E. Lawlor, Arna Andrews, David Leong, Andrew D. Nash
Publikováno v:
The Journal of Immunology. 197:4392-4402
G-CSF is a hemopoietic growth factor that has a role in steady state granulopoiesis, as well as in mature neutrophil activation and function. G-CSF– and G-CSF receptor–deficient mice are profoundly protected in several models of rheumatoid arthri
Autor:
Jason Simmonds, Anna Tjärnlund-Wolf, Holger Lind, Arna Andrews, Philipp Claar, Stefan Schulte, Sabine Pestel, Steven K. Dower, Peter Schmidt, Marcel Mischnik, Thomas Weimer, Vesna Tomasetig, Elmar Raquet, Hans-Wilhelm Beltz
Publikováno v:
Blood Adv
A novel mechanism for extending the circulatory half-life of coagulation factor VIII (FVIII) has been established and evaluated preclinically. The FVIII binding domain of von Willebrand factor (D′D3) fused to human albumin (rD′D3-FP) dose depende
Autor:
Eva Herzog, Michael J. Wilson, Elmar Raquet, Marcel Mischnik, Arna Andrews, Sabine Pestel, Steve K. Dower, Philipp Claar, Thomas Weimer
Publikováno v:
Science meets clinical practice.
Autor:
Cheryl Ireland, Dennis M. Zaller, Arna Andrews, Manuel Baca, Nicholas T. Redpath, Thomas P. J. Garrett, Yibin Xu, Robin Ernst, Douglas J. Hilton, Andrea Woods, William R. Strohl, Cindy S. Luo, Louis Fabri, Ping Lu, Nicos A. Nicola, Peter E. Czabotar, Gail Forrest, Jian-Guo Zhang, Andrew D. Nash, Hal Braley, Nicholas J. Wilson, Zhiqiang An
Publikováno v:
The Biochemical journal. 451(2)
Gene deletion studies in mice have revealed critical roles for IL (interleukin)-4 and -13 in asthma development, with the latter controlling lung airways resistance and mucus secretion. We have now developed human neutralizing monoclonal antibodies a
Autor:
Kirsten Edwards, Andrew D. Nash, Sandra Koernig, Con Panousis, Ian K. Campbell, Brent S. McKenzie, David Leong, Arna Andrews, Kate E. Lawlor, Milica Ng, Veronica Rayzman, Gabrielle L. Goldberg, Ian P. Wicks
Publikováno v:
Cytokine. 70:32
Granulocyte colony-stimulating factor (G-CSF) is a haemopoietic cytokine first identified for its role in steady state granulopoiesis but is now also recognised as a proinflammatory mediator of mature neutrophil activation and function. G-CSF binds t
Autor:
Kirsten Edwards, Karen Scalzo-Inguanti, Arna Andrews, Andrew D. Nash, Samantha J. Busfield, Katherine Monaghan, Shirley Taylor
Publikováno v:
Cytokine. 70:68
Neutrophils are the most abundant white blood cells (40–60%) and play an essential role in initiating the clearance of bacterial and fungal infections and maintaining inflammation. Tight regulation of both neutrophil number and recruitment to sites