Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries.

Autor: García-Marín LM; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia., Campos AI; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; Institute for Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia., Diaz-Torres S; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.; Population Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Rabinowitz JA; Department of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA., Ceja Z; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia., Mitchell BL; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia., Grasby KL; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia., Thorp JG; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Agartz I; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.; Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Stockholm, Sweden., Alhusaini S; Department of Neurology, Alpert Medical School of Brown University, Providence, RI, USA.; Molecular and Cellular Therapeutics Department, Royal College of Surgeons in Ireland, Dublin, Ireland., Ames D; Academic Unit Psychiatry of Old Age, University of Melbourne, Melbourne, Victoria, Australia.; National Ageing Research Institute, Parkville, Victoria, Australia., Amouyel P; Universite Lille, U1167-RID-AGE-LabEx DISTALZ-Risk Factors and Molecular Determinants of Aging Diseases, Lille, France.; Institut National de la Santé et de la Recherche Médicale, Lille, France.; Centre Hospitalier Universitaire de Lille Department of Public Health, Lille, France.; Institut Pasteur de Lille UMR1167, Lille, France., Andreassen OA; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway., Arfanakis K; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA., Arias-Vasquez A; Departments of Psychiatry and Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands., Armstrong NJ; Department of Mathematics and Statistics, Curtin University, Perth, Western Australia, Australia., Athanasiu L; Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; CoE NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Bastin ME; Centre for Clinical Brain Sciences and Edinburgh Imaging, University of Edinburgh, Edinburgh, UK., Beiser AS; Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.; Framingham Heart Study, Chobanian and Avedisian Boston University School of Medicine, Boston, MA, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Boks MPM; Brain Center University Medical Center Utrecht, Utrecht, The Netherlands., Boomsma DI; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, The Netherlands., Brodaty H; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia., Brouwer RM; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, The Netherlands., Buitelaar JK; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands., Burkhardt R; Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg University, Regensburg, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany., Cahn W; Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.; Altrecht Mental Health Institute, Utrecht, The Netherlands., Calhoun VD; Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS)-Georgia State, Georgia Tech and Emory University, Atlanta, GA, USA., Carmichael OT; Pennington Biomedical Research Center, Baton Rouge, LA, USA., Chakravarty M; Cerebral Imaging Centre, Douglas Research Centre, Montreal, Quebec, Canada.; Department of Psychiatry, McGill University, Montreal, Quebec, Canada., Chen Q; Lieber Institute for Brain Development, Baltimore, MD, USA., Ching CRK; Laboratory of Neuro Imaging, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Cichon S; Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany.; Department of Biomedicine, University of Basel, Basel, Switzerland.; Medical Genetics, Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland., Crespo-Facorro B; HU Virgen del Rocio, Instituto de Investigacion Biomedica IBIS-CSIC, Universidad de Sevilla, CIBERSAM, Sevilla, Spain., Crivello F; CNRS, IMN, UMR 5293, University of Bordeaux, Bordeaux, France., Dale AM; Center for Multimodal Imaging and Genetics, La Jolla, CA, USA., Smith GD; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, University of Bristol, Bristol, UK., de Geus EJC; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., De Jager PL; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York City, NY, USA., de Zubicaray GI; School of Psychology and Counselling, Queensland University of Technology, Brisbane, Queensland, Australia., Debette S; INSERM U1219, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.; Department of Neurology, Institute of Neurodegenerative Diseases, Bordeaux University Hospital, Bordeaux, France., DeCarli C; Imaging of Dementia and Aging Laboratory, Department of Neurology, University of California, Davis, Sacramento, CA, USA., Depondt C; Department of Neurology, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels, Belgium., Desrivières S; Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Djurovic S; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.; Department of Clinical Science, University of Bergen, Bergen, Norway., Ehrlich S; Translational Developmental Neuroscience Section, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Dresden, Germany., Erk S; German Center of Mental Health (DZPG), Partner Site Berlin/Potsdam, Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Espeseth T; Department of Psychology, University of Oslo, Oslo, Norway.; Department of Psychology, Oslo New University College, Oslo, Norway., Fernández G; Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands., Filippi I; INSERM U1299, Paris Saclay University, Gif-sur-Yvette, France., Fisher SE; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands., Fleischman DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA., Fletcher E; Department of Neurology, University of California, Davis, Davis, CA, USA., Fornage M; Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Forstner AJ; Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany.; Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany., Francks C; Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.; Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands., Franke B; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands., Ge T; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Goldman AL; Lieber Institute for Brain Development, Baltimore, MD, USA., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Green RC; Department of Medicine (Genetics), Mass General Brigham and Harvard Medical School, Boston, MA, USA., Grimm O; Central Institute of Mental Health, Mannheim, Germany.; Goethe-University Frankfurt, Frankfurt, Germany., Groenewold NA; Department of Psychiatry and Mental Health, Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Gruber O; Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Håberg AK; Department of Neuromedicine and Movement, NTNU Science, Trondheim, Norway.; MiDT National Research Center, Department of Research, St Olavs Hospital, Trondheim, Norway., Haukvik UK; Norwegian Centre for Mental Health Research (NORMENT), Department of Mental Health and Addiction, University of Oslo, Oslo, Norway.; Centre for Forensic Psychiatry Research, Oslo University Hospital, Oslo, Norway., Heinz A; German Center of Mental Health (DZPG), Partner Site Berlin/Potsdam, Berlin, Germany.; Centre for Forensic Psychiatry Research, Oslo University Hospital, Oslo, Norway., Hibar DP; Product Development, Genentech, Inc., South San Francisco, CA, USA., Hilal S; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore City, Singapore., Himali JJ; Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.; Framingham Heart Study, Chobanian and Avedisian Boston University School of Medicine, Boston, MA, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.; Department of Population Health Sciences, UT Health Science Center San Antonio, San Antonio, TX, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Ho BC; Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA., Hoehn DF; Max Planck Institute of Psychiatry, Munich, Germany., Hoekstra PJ; Department of Child and Adolescent Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Accare Child Study Center, Groningen, The Netherlands., Hofer E; Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria., Hoffmann W; German Centre for Neurodegenerative Diseases (DZNE)-Site Rostock/Greifswald, Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Holmes AJ; Department of Psychiatry, Brain Health Institute, Rutgers University, Piscataway, NJ, USA., Homuth G; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Hosten N; Department of Radiology, University Clinic Greifswald, Greifswald, Germany., Ikram MK; Departments of Epidemiology and Neurology, Erasmus MC, Rotterdam, The Netherlands., Ipser JC; Department of Psychiatry and Mental Health, Neuroscience Institute, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa., Jack CR Jr; Department of Radiology, Mayo Clinic, Rochester, MN, USA., Jahanshad N; Laboratory of Neuro Imaging, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Jönsson EG; Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Sciences, Stockholm Region, Stockholm, Sweden., Kahn RS; Altrecht Mental Health Institute, Utrecht, The Netherlands., Kanai R; Araya, Inc, Tokyo, Japan., Klein M; Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands., Knol MJ; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Launer LJ; Intramural Research Program, National Institute on Aging, Baltimore, MD, USA., Lawrie SM; Division of Psychiatry, University of Edinburgh, Edinburgh, UK., Hellard SL; Department of Clinical Science, University of Bergen, Bergen, Norway., Lee PH; Center for Genomic Medicine, Mass General Brigham, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Stanley Center for Psychiatry, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lemaître H; Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, UMR 5293, CNRS, Université de Bordeaux, Bordeaux, France., Li S; Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.; Framingham Heart Study, Chobanian and Avedisian Boston University School of Medicine, Boston, MA, USA., Liewald DCM; PPLS, University of Edinburgh, Edinburgh, UK., Lin H; Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Longstreth WT Jr; Department of Neurology, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Lopez OL; Departments of Neurology and Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Luciano M; Department of Psychology, University of Edinburgh, Edinburgh, UK., Maillard P; Department of Neurology, University of California, Davis, Davis, CA, USA., Marquand AF; Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands., Martin NG; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Martinot JL; Université Paris-Saclay, Institut National de la Santé et de la Recherche Médicale, INSERM U1299 'Trajectoires développementales Psychiatrie', Ecole Normale Supérieure Paris-Saclay, CNRS UMR 9010, Université Paris Cité, Centre Borelli, Gif sur Yvette, France., Mather KA; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia., Mattay VS; Lieber Institute for Brain Development, Baltimore, MD, USA., McMahon KL; School of Clinical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia., Mecocci P; Institute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.; Clinical Geriatrics, NVS Department, Karolinska Institute, Huddinge, Sweden., Melle I; Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Meyer-Lindenberg A; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Mirza-Schreiber N; Institute of Neurogenomics, Helmholtz Munich, Neuherberg, Germany.; Neurogenetic Systems Analysis Group, Institute of Neurogenomics, Helmholtz Munich, Neuherberg, Germany., Milaneschi Y; Department of Psychiatry, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health, Mental Health Program, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep and Stress Program, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Complex Trait Genetics Program, Amsterdam, The Netherlands., Mosley TH; MIND Center, Jackson, MS, USA., Mühleisen TW; Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany.; Cécile and Oskar Vogt Institute for Brain Research, Medical Faculty, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland., Müller-Myhsok B; Statistics Genetics Group, Max Planck Institute of Psychiatry, Munich, Germany., Maniega SM; Centre for Clinical Brain Sciences and Edinburgh Imaging, University of Edinburgh, Edinburgh, UK., Nauck M; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany., Nho K; Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA., Niessen WJ; University Medical Center Groningen, Groningen, The Netherlands., Nöthen MM; Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany., Nyquist PA; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.; General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA., Oosterlaan J; Clinical Neuropsychology Section, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Emma Children's Hospital, University Medical Centers Amsterdam, Amsterdam, The Netherlands.; Amsterdam Reproduction and Development Research Institute, Amsterdam, The Netherlands., Pandolfo M; Université Libre de Bruxelles, Brussels, Belgium.; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada., Paus T; Departments of Psychiatry and Neuroscience, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada.; Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, Quebec, Canada., Pausova Z; Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Physiology, University of Toronto, Toronto, Ontario, Canada., Penninx BWJH; Department of Psychiatry, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Pike GB; Departments of Radiology and Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Systems and Population Health, Seattle, WA, USA., Pütz B; Translational Psychiatry, Munich, Germany., Reppermund S; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.; Department of Developmental Disability Neuropsychiatry, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia., Rietschel MD; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany., Risacher SL; Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA., Romanczuk-Seiferth N; Department of Psychiatry and Neuroscience, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Department of Psychology, Clinical Psychology and Psychotherapy, MSB Medical School Berlin, Berlin, Germany., Romero-Garcia R; Departamento de Fisiología Médica y Biofísica, Instituto de Biomedicina de Sevilla (IBiS) HUVR/CSIC/Universidad de Sevilla/CIBERSAM, ISCIII, Sevilla, Spain.; Department of Psychiatry, University of Cambridge, Cambridge, UK., Roshchupkin GV; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Sachdev PS; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.; Neuropsychiatric Institute, The Prince of Wales Hospital, Randwick, New South Wales, Australia., Sämann PG; Max Planck Institute of Psychiatry, Munich, Germany., Saremi A; Laboratory of Neuro Imaging, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Sargurupremraj M; INSERM U1219, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Saykin AJ; Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA., Schmaal L; Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria, Australia.; Orygen, Parkville, Victoria, Australia., Schmidt H; Institute of Molecular Biology and Biochemistry, Gottfried Schatz Center for Signaling, Metabolism and Aging, Medical University Graz, Graz, Austria., Schmidt R; Department of Neurology, Medical University Graz Austria, Graz, Austria., Schofield PR; Neuroscience Research Australia, Sydney, New South Wales, Australia.; School of Biomedical Sciences, University of New South Wales, Sydney, New South Wales, Australia., Scholz M; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany., Schumann G; German Center of Mental Health (DZPG), Partner Site Berlin/Potsdam, Berlin, Germany.; Department of Psychiatry, University of Cambridge, Cambridge, UK.; Centre for Population Neuroscience and Stratified Medicine (PONS), ISTBI, Fudan University, Shanghai, PR China.; PONS Centre, Department of Psychiatry, CCM, Charite Unversitaetsmedizin Berlin, Berlin, Germany., Schwarz E; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Shen L; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Shin J; The Hospital for Sick Children, Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada., Sisodiya SM; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.; Chalfont Centre for Epilepsy, Chalfont St Peter, UK., Smith AV; Icelandic Heart Association, Kopavogur, Iceland.; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA., Smoller JW; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Soininen HS; Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Steen VM; Department of Clinical Science, University of Bergen, Bergen, Norway.; Dr. Einar Martens Research Group for Biological Psychiatry, Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway., Stein DJ; SAMRC Research Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Stein JL; Department of Genetics and UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Thomopoulos SI; Laboratory of Neuro Imaging, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Toga AW; Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA., Tordesillas-Gutiérrez D; Instituto de Física de Cantabria (CSIC-UC), Santander, Spain.; Department of Radiology, Marqués de Valdecilla University Hospital, Valdecilla Biomedical Research Institute IDIVAL, Santander, Spain., Trollor JN; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.; The National Centre of Excellence in Intellectual Disability Health, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia., Valdes-Hernandez MC; Centre for Clinical Brain Sciences and Edinburgh Imaging, University of Edinburgh, Edinburgh, UK., van T Ent D; Department of Biological Psychology and Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., van Bokhoven H; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands., van der Meer D; Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; School of Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands., van der Wee NJA; Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands., Vázquez-Bourgon J; Department of Psychiatry, University Hospital Marqués de Valdecilla-IDIVAL, Santander, Spain.; Departamento de Medicina y Psiquiatría, Universidad de Cantabria, Santander, Spain.; Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM), Sevilla, Spain., Veltman DJ; Department of Psychiatry, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Vernooij MW; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Villringer A; Department of Neurology, Max Planck Institute for Human, Cognitive and Brain Sciences, Leipzig, Germany.; Cognitive Neurology, University of Leipzig Medical Center, Leipzig, Germany., Vinke LN; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Völzke H; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Walter H; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Wardlaw JM; Centre for Clinical Brain Sciences and Edinburgh Imaging, University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute Centre, University of Edinburgh, Edinburgh, UK., Weinberger DR; Lieber Institute for Brain Development, Baltimore, MD, USA.; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA., Weiner MW; University of California, San Francisco, San Francisco, CA, USA.; Northern California Institute for Research and Education (NCIRE), San Francisco, CA, USA.; Veterans Administration Medical Center, San Francisco, CA, USA., Wen W; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia., Westlye LT; Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Psychology, University of Oslo, Oslo, Norway., Westman E; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Huddinge, Sweden., White T; Section on Social and Cognitive Developmental Neuroscience, National Institute of Mental Health, Bethesda, MD, USA., Witte AV; Department of Neurology, Max Planck Institute for Human, Cognitive and Brain Sciences, Leipzig, Germany.; Cognitive Neurology, University of Leipzig Medical Center, Leipzig, Germany., Wolf C; Max Planck Institute of Psychiatry, Munich, Germany., Yang J; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., Zwiers MP; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands., Ikram MA; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Seshadri S; Framingham Heart Study, Chobanian and Avedisian Boston University School of Medicine, Boston, MA, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Thompson PM; Laboratory of Neuro Imaging, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Satizabal CL; Framingham Heart Study, Chobanian and Avedisian Boston University School of Medicine, Boston, MA, USA.; Department of Population Health Sciences and Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX, USA.; Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA., Medland SE; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.; School of Psychology and Counselling, Queensland University of Technology, Brisbane, Queensland, Australia.; School of Psychology, The University of Queensland, Brisbane, Queensland, Australia., Rentería ME; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. miguel.renteria@qimrberghofer.edu.au.; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia. miguel.renteria@qimrberghofer.edu.au.

Publikováno v: Nature genetics [Nat Genet] 2024 Oct 21. Date of Electronic Publication: 2024 Oct 21.

Heritability of Gene Expression Measured from Peripheral Blood in Older Adults.

Autor: Kanchibhotla SC; Centre for Healthy Brain Ageing, Discipline of Psychiatry & Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia., Mather KA; Centre for Healthy Brain Ageing, Discipline of Psychiatry & Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia.; Neuroscience Research Australia, Sydney, NSW 2031, Australia., Armstrong NJ; Department of Mathematics and Statistics, Curtin University, Perth, WA 6845, Australia., Ciobanu LG; Discipline of Psychiatry, Adelaide Medical School, The University of Adelaide, Adelaide, SA 5005, Australia., Baune BT; Discipline of Psychiatry, Adelaide Medical School, The University of Adelaide, Adelaide, SA 5005, Australia.; Department of Psychiatry, University of Münster, 48149 Münster, Germany.; Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, VIC 3052, Australia.; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC 3052, Australia., Catts VS; Centre for Healthy Brain Ageing, Discipline of Psychiatry & Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia., Schofield PR; Neuroscience Research Australia, Sydney, NSW 2031, Australia.; School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia., Trollor JN; Centre for Healthy Brain Ageing, Discipline of Psychiatry & Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia.; Department of Developmental Disability Neuropsychiatry, Discipline of Psychiatry & Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia., Ames D; Academic Unit for Psychiatry of Old Age, University of Melbourne, St George's Hospital, Kew, Melbourne, VIC 3010, Australia.; National Ageing Research Institute, Parkville, VIC 3052, Australia., Sachdev PS; Centre for Healthy Brain Ageing, Discipline of Psychiatry & Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia.; Neuropsychiatric Institute, Euroa Centre, Prince of Wales Hospital, Sydney, NSW 2031, Australia., Thalamuthu A; Centre for Healthy Brain Ageing, Discipline of Psychiatry & Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia.

Publikováno v: Genes [Genes (Basel)] 2024 Apr 16; Vol. 15 (4). Date of Electronic Publication: 2024 Apr 16.

Multi-omics and pathway analyses of genome-wide associations implicate regulation and immunity in verbal declarative memory performance.

Autor: Mei H; Department of Data Science, John D. Bower School of Population Health, University of Mississippi Medical Center, Jackson, MS, USA. hmei@umc.edu.; Gertrude C. Ford Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, MS, USA. hmei@umc.edu., Simino J; Department of Data Science, John D. Bower School of Population Health, University of Mississippi Medical Center, Jackson, MS, USA. jsimino@umc.edu.; Gertrude C. Ford Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, MS, USA. jsimino@umc.edu., Li L; Department of Biology, Tougaloo College, Jackson, MS, USA., Jiang F; Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Bis JC; Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Davies G; Department of Psychology, Lothian Birth Cohorts Group, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK., Hill WD; Department of Psychology, Lothian Birth Cohorts Group, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK., Xia C; Department of Psychology, Lothian Birth Cohorts Group, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Yang Q; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA., Lahti J; Turku Institute for Advanced Research, University of Turku, Turku, Finland.; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Kirin M; Work completed while at The University of Edinburgh, Edinburgh, UK., De Jager P; Taub Institute for Research On Alzheimer's Disease and the Aging Brain, Columbia Irving University Medical Center, New York, NY, USA.; Center for Translational and Computational Neuro-Immunology, Columbia University Medical Center, New York, NY, USA.; Department of Neurology, Columbia University Medical Center, New York, NY, USA., Armstrong NJ; Mathematics and Statistics, Curtin University, Perth, Australia., Ghanbari M; Department of Epidemiology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands., Kolcic I; School of Medicine, University of Split, Split, Croatia., Moran C; Department of Geriatric Medicine, Frankston Hospital, Peninsula Health, Melbourne, Australia.; Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Sargurupremraj M; Inserm, Bordeaux Population Health Research Center, Team VINTAGE, UMR 1219, University of Bordeaux, Bordeaux, France., Mahmud S; Department of Data Science, John D. Bower School of Population Health, University of Mississippi Medical Center, Jackson, MS, USA., Fornage M; The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Satizabal CL; The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Polasek O; School of Medicine, University of Split, Split, Croatia.; Algebra University College, Ilica 242, Zagreb, Croatia., Räikkönen K; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Liewald DC; Department of Psychology, Lothian Birth Cohorts Group, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK., Homuth G; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Callisaya M; Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia.; Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia., Mather KA; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.; Neuroscience Research Australia, Sydney, Australia., Windham BG; Gertrude C. Ford Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, MS, USA.; Department of Medicine, Division of Geriatrics, School of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Zemunik T; School of Medicine, University of Split, Split, Croatia., Palotie A; Department of Medicine, Department of Neurology and Department of Psychiatry, Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; The Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Pattie A; Department of Psychology, Lothian Birth Cohorts Group, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK., van der Auwera S; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Thalamuthu A; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.; Neuroscience Research Australia, Sydney, Australia., Knopman DS; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Rudan I; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK., Starr JM; Department of Psychology, Lothian Birth Cohorts Group, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, EH8 9JZ, UK., Wittfeld K; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.; German Center for Neurodegenerative Diseases (DZNE), Site Rostock/ Greifswald, Rostock, Germany., Kochan NA; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia., Griswold ME; Gertrude C. Ford Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, MS, USA.; Department of Medicine, School of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Vitart V; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Brodaty H; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.; Dementia Centre for Research Collaboration, University of New South Wales, Sydney, NSW, Australia., Gottesman R; Stroke, Cognition, and Neuroepidemiology (SCAN) Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Cox SR; Department of Psychology, Lothian Birth Cohorts Group, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK., Psaty BM; Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Services, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Boerwinkle E; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Chasman DI; Harvard Medical School, Boston, MA, USA.; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA., Grodstein F; Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Epidemiology, Harvard T.H Chan School of Public Health, Harvard University, Boston, MA, USA., Sachdev PS; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.; Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia., Srikanth V; Department of Geriatric Medicine, Frankston Hospital, Peninsula Health, Melbourne, Australia.; Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia.; Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia., Hayward C; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Wilson JF; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Eriksson JG; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Department of Public Health Solutions, Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.; Folkhälsan Research Centre, Helsinki, Finland., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.; German Center for Neurodegenerative Diseases (DZNE), Site Rostock/ Greifswald, Rostock, Germany., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., Ikram MA; Department of Epidemiology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands., Deary IJ; Department of Psychology, Lothian Birth Cohorts Group, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK., van Duijn CM; Nuffield Department of Population Health, Medical Sciences Division, University of Oxford, Oxford, UK., Launer L; Laboratory of Epidemiology and Population Sciences, National Institute On Aging, Bethesda, MD, USA., Fitzpatrick AL; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Family Medicine, University of Washington, Seattle, WA, USA., Seshadri S; The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Bressler J; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Debette S; Inserm, Bordeaux Population Health Research Center, Team VINTAGE, UMR 1219, University of Bordeaux, Bordeaux, France.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Neurology, CHU de Bordeaux, Bordeaux, France., Mosley TH Jr; Gertrude C. Ford Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, MS, USA.; Department of Medicine, School of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.; Department of Neurology, University of Mississippi Medical Center, Jackson, MS, USA.

Publikováno v: Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Jan 20; Vol. 16 (1), pp. 14. Date of Electronic Publication: 2024 Jan 20.

SHP2 inhibitors maintain TGFβ signalling through SMURF2 inhibition.

Autor: Lai X; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.; NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore., Lui SKL; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Lam HY; NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore., Adachi Y; Division of Molecular Therapeutics, Aichi Cancer Center Research Institute, Nagoya, Aichi, 464-8681, Japan.; Division of Advanced Cancer Therapeutics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, 466-8650, Japan., Sim WJ; Institute of Molecular and Cell Biology, A*STAR, Singapore, 138672, Singapore., Vasilevski N; Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia.; Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia., Armstrong NJ; School of Electrical Engineering, Computing and Mathematical Sciences, Faculty of Science and Engineering, Curtin University, Bentley, WA, 6102, Australia., Bridgeman SC; Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia.; Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia., Main NM; Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia.; Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia., Tan TZ; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Tirnitz-Parker JEE; Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia.; Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia., Thiery JP; Institute of Molecular and Cell Biology, A*STAR, Singapore, 138672, Singapore. tjp@visitor.nus.edu.sg.; Guangzhou Laboratory, Guangzhou International Bio Island, Haizhu District, Guangzhou, Guangdong, 510530, China. tjp@visitor.nus.edu.sg., Ebi H; Division of Molecular Therapeutics, Aichi Cancer Center Research Institute, Nagoya, Aichi, 464-8681, Japan. hebi@aichi-cc.jp.; Division of Advanced Cancer Therapeutics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, 466-8650, Japan. hebi@aichi-cc.jp., Kumar AP; NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore, Singapore. apkumar@nus.edu.sg.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore. apkumar@nus.edu.sg., Eichhorn PJA; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. Pieter.eichhorn@curtin.edu.au.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore. Pieter.eichhorn@curtin.edu.au.; Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia. Pieter.eichhorn@curtin.edu.au.; Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia. Pieter.eichhorn@curtin.edu.au.

Publikováno v: NPJ precision oncology [NPJ Precis Oncol] 2023 Dec 15; Vol. 7 (1), pp. 136. Date of Electronic Publication: 2023 Dec 15.

Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume.

Autor: Milicic L; Centre for Precision Health, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia, 6027, Australia.; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, 6027, Australia., Vacher M; Centre for Precision Health, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia, 6027, Australia.; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, 6027, Australia.; CSIRO Health and Biosecurity, Australian E-Health Research Centre, Floreat, Western Australia, 6014, Australia., Porter T; Centre for Precision Health, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia, 6027, Australia.; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, 6027, Australia.; School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, 6102, Australia., Doré V; Australian E-Health Research Centre, CSIRO, Parkville, Victoria, 3052, Australia.; Department of Molecular Imaging and Therapy and Centre for PET, Austin Health, Heidelberg, Victoria, Australia., Burnham SC; Centre for Precision Health, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia, 6027, Australia.; Australian E-Health Research Centre, CSIRO, Parkville, Victoria, 3052, Australia., Bourgeat P; Australian E-Health Research Centre, CSIRO, Herston, Queensland, 4029, Australia., Shishegar R; Australian E-Health Research Centre, CSIRO, Parkville, Victoria, 3052, Australia.; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, Melbourne, VIC, Australia., Doecke J; Centre for Precision Health, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia, 6027, Australia.; Australian E-Health Research Centre, CSIRO, Herston, Queensland, 4029, Australia., Armstrong NJ; Department of Mathematics and Statistics, Curtin University, Bentley, Western Australia, Australia., Tankard R; School of Mathematics and Statistics, Murdoch University, Perth, Western Australia, Australia., Maruff P; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3052, Australia.; Cogstate Ltd, Melbourne, VIC, Australia., Masters CL; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3052, Australia., Rowe CC; Department of Molecular Imaging and Therapy and Centre for PET, Austin Health, Heidelberg, Victoria, Australia.; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3052, Australia., Villemagne VL; Centre for Precision Health, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia, 6027, Australia.; Department of Molecular Imaging and Therapy and Centre for PET, Austin Health, Heidelberg, Victoria, Australia.; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA., Laws SM; Centre for Precision Health, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia, 6027, Australia. s.laws@ecu.edu.au.; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, 6027, Australia. s.laws@ecu.edu.au.; School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, 6102, Australia. s.laws@ecu.edu.au.

Publikováno v: GeroScience [Geroscience] 2022 Jun; Vol. 44 (3), pp. 1807-1823. Date of Electronic Publication: 2022 Apr 21.