Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Armiyaw S. Nasamu"'
Autor:
Selina Bopp, Charisse Flerida A. Pasaje, Robert L. Summers, Pamela Magistrado-Coxen, Kyra A. Schindler, Victoriano Corpas-Lopez, Tomas Yeo, Sachel Mok, Sumanta Dey, Sebastian Smick, Armiyaw S. Nasamu, Allison R. Demas, Rachel Milne, Natalie Wiedemar, Victoria Corey, Maria De Gracia Gomez-Lorenzo, Virginia Franco, Angela M. Early, Amanda K. Lukens, Danny Milner, Jeremy Furtado, Francisco-Javier Gamo, Elizabeth A. Winzeler, Sarah K. Volkman, Maëlle Duffey, Benoît Laleu, David A. Fidock, Susan Wyllie, Jacquin C. Niles, Dyann F. Wirth
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Drug resistance to current antimalarials is rising and new drugs and targets are urgently needed. Here the authors identify Plasmodium falciparum acyl-CoA synthetase 10 as a new target whose inhibition leads to a decrease in triacylglycerols.
Externí odkaz:
https://doaj.org/article/8ae40ec50bdc468aaa960a15e9ca87b3
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT Following each round of replication, daughter merozoites of the malaria parasite Plasmodium falciparum escape (egress) from the infected host red blood cell (RBC) by rupturing the parasitophorous vacuole membrane (PVM) and the RBC membrane (
Externí odkaz:
https://doaj.org/article/a011e64ff0ab462c8f240a0470c60b13
Autor:
Armiyaw S. Nasamu, Alejandra Falla, Charisse Flerida A. Pasaje, Bridget A. Wall, Jeffrey C. Wagner, Suresh M. Ganesan, Stephen J. Goldfless, Jacquin C. Niles
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Establishing robust genome engineering methods in the malarial parasite, Plasmodium falciparum, has the potential to substantially improve the efficiency with which we gain understanding of this pathogen’s biology to propel treatment and e
Externí odkaz:
https://doaj.org/article/e9d76cd561ad4d1a993ae54780056e38
Autor:
Suresh M. Ganesan, Alejandra Falla, Stephen J. Goldfless, Armiyaw S. Nasamu, Jacquin C. Niles
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Current strategies for regulatory control of gene expression are orthogonal to the host organism mechanisms. Here the authors demonstrate an RNA aptamer controlled system integrated into native regulatory pathways in the parasite Plasmodium falciparu
Externí odkaz:
https://doaj.org/article/de4f9192e8bb4c6ba4ebcaac687eed22
Autor:
Pablo Cárdenas, Gaël Chambonnier, Lisl Y. Esherick, Jacquin C. Niles, Sumanta Dey, Armiyaw S. Nasamu, Christopher V. Turlo
Publikováno v:
The CRISPR Journal. 5:155-164
Functional characterization of the multitude of poorly-described proteins in the human malarial pathogen, Plasmodium falciparum, requires tools to enable genome-scale perturbation studies. Here we present GeneTargeter (genetargeter.mit.edu), a softwa
Publikováno v:
bioRxiv
Following each round of replication, daughter merozoites of the malaria parasitePlasmodium falciparumescape (egress) from the infected host red blood cell (RBC) by rupturing the parasitophorous vacuole membrane (PVM) and the RBC membrane (RBCM). A pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5233bdad21768a398e159d28d73eda4a
https://europepmc.org/articles/PMC9882241/
https://europepmc.org/articles/PMC9882241/
Publikováno v:
J Biol Chem
Plasmepsins are a group of diverse aspartic proteases in the malaria parasite Plasmodium. Their functions are strikingly multifaceted, ranging from hemoglobin degradation to secretory organelle protein processing for egress, invasion, and effector ex
Autor:
Angela O. Achieng, Kailash C. Pandey, Amit Singh, Mansi Pandit, Poonam, Brajendra K. Singh, Daniel E. Goldberg, Ben M. Dunn, Ramesh Chandra, Brijesh Rathi, Prakasha Kempaiah, Latha Narayanan, Snigdha Singh, Jiang He, Afshana Quadiri, Akansha Pant, Agam P. Singh, Armiyaw S. Nasamu, Prahlad C. Ghosh, Vandana, Vinoth Rajendran, Jyoti Prakash Singh, Nikesh Gupta
Publikováno v:
ACS Infectious Diseases. 5:184-198
The eradication of malaria remains challenging due to the complex life cycle of Plasmodium and the rapid emergence of drug-resistant forms of Plasmodium falciparum and Plasmodium vivax. New, effective, and inexpensive antimalarials against multiple l
Publikováno v:
ACS Infectious Diseases
Upon infecting a red blood cell (RBC), the malaria parasite Plasmodium falciparum drastically remodels its host by exporting hundreds of proteins into the RBC cytosol. This protein export program is essential for parasite survival. Hence export-relat
Autor:
Jacquin C. Niles, Ajay Pillai, Abdullah A. B. Bokhari, Suresh M. Ganesan, Armiyaw S. Nasamu, Sanjay A. Desai, Jeanine Gezelle, Gagandeep Singh Saggu, Anna K. Crater, Ankit Gupta
Publikováno v:
PLoS Pathogens, Vol 16, Iss 2, p e1008363 (2020)
PLoS Pathogens
PLoS Pathogens
Malaria parasites activate a broad-selectivity ion channel on their host erythrocyte membrane to obtain essential nutrients from the bloodstream. This conserved channel, known as the plasmodial surface anion channel (PSAC), has been linked to parasit