Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Armindo Salvador"'
Publikováno v:
Redox Biology, Vol 69, Iss , Pp 103000- (2024)
In the cytosol of human cells under low oxidative loads, hydrogen peroxide is confined to microdomains around its supply sites, due to its fast consumption by peroxiredoxins. So are the sulfenic and disulfide forms of the 2-Cys peroxiredoxins, accord
Externí odkaz:
https://doaj.org/article/8baca81b17594305b878708b9bfb1c71
Autor:
Maria J. Ferreira, Tony A. Rodrigues, Ana G. Pedrosa, Luís Gales, Armindo Salvador, Tânia Francisco, Jorge E. Azevedo
Publikováno v:
Redox Biology, Vol 63, Iss , Pp 102764- (2023)
Despite the large amounts of H2O2 generated in mammalian peroxisomes, cysteine residues of intraperoxisomal proteins are maintained in a reduced state. The biochemistry behind this phenomenon remains unexplored, and simple questions such as “is the
Externí odkaz:
https://doaj.org/article/1cf19b1fe0fc4b3b8ec2e7a924a0fbe5
Publikováno v:
Redox Biology, Vol 58, Iss , Pp 102527- (2022)
Paracrine superoxide (O2•−) and hydrogen peroxide (H2O2) signaling critically depends on these substances' concentrations, half-lives and transport ranges in extracellular media. Here we estimated these parameters for the lumen of human capillari
Externí odkaz:
https://doaj.org/article/57779d36b7fe413687e49d49db5d8db7
Autor:
Heng Yang Lee, Azlin Ithnin, Raja Zahratul Azma, Ainoon Othman, Armindo Salvador, Fook Choe Cheah
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2022)
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a prevalent condition worldwide and is caused by loss-of-function mutations in the G6PD gene. Individuals with deficiency are more susceptible to oxidative stress which leads to the classical, ac
Externí odkaz:
https://doaj.org/article/56271da16c9a418998f80a44c5890c49
Autor:
Maria João Moreno, Armindo Salvador
Publikováno v:
Molecules, Vol 28, Iss 7, p 3136 (2023)
Ligand-protein interactions are usually studied in complex media that also contain lipids. This is particularly relevant for membrane proteins that are always associated with lipid bilayers, but also for water-soluble proteins studied in in vivo cond
Externí odkaz:
https://doaj.org/article/480d3902534a4f868f0f72591105b4ff
Autor:
Maria João Moreno, Luís M. S. Loura, Jorge Martins, Armindo Salvador, Adrian Velazquez-Campoy
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9757 (2022)
The equilibrium distribution of small molecules (ligands) between binding agents in heterogeneous media is an important property that determines their activity. Heterogeneous systems containing proteins and lipid membranes are particularly relevant d
Externí odkaz:
https://doaj.org/article/50b6e061a53a44b1b86d81555146bd24
Publikováno v:
Membranes, Vol 12, Iss 3, p 254 (2022)
Predicting the rate at which substances permeate membrane barriers in vivo is crucial for drug development. Permeability coefficients obtained from in vitro studies are valuable for this goal. These are normally determined by following the dynamics o
Externí odkaz:
https://doaj.org/article/e8e7360d2d2c4eea90925721c4e88f94
Publikováno v:
Redox Biology, Vol 15, Iss C, Pp 297-315 (2018)
The system (PTTRS) formed by typical 2-Cys peroxiredoxins (Prx), thioredoxin (Trx), Trx reductase (TrxR), and sulfiredoxin (Srx) is central in antioxidant protection and redox signaling in the cytoplasm of eukaryotic cells. Understanding how the PTTR
Externí odkaz:
https://doaj.org/article/ffb9185e292841e2b0de3ec637f127d8
Autor:
Rui D.M. Travasso, Fernando Sampaio dos Aidos, Anahita Bayani, Pedro Abranches, Armindo Salvador
Publikováno v:
Redox Biology, Vol 12, Iss , Pp 233-245 (2017)
Hydrogen peroxide (H2O2) is a key signaling agent. Its best characterized signaling actions in mammalian cells involve the early oxidation of thiols in cytoplasmic phosphatases, kinases and transcription factors. However, these redox targets are orde
Externí odkaz:
https://doaj.org/article/e6ab497a333a4e7eae6cf01665377e8f
Autor:
Luís M.B.B. Estronca, Hugo A.L. Filipe, Armindo Salvador, Maria João Moreno, Winchil L.C. Vaz
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 6, Pp 1033-1043 (2014)
The rate of noncatalyzed transfer of cholesterol (Chol) among lipoproteins and cells in the blood is of fundamental importance as a baseline to assess the role of active transport mechanisms, but remains unknown. Here we address this gap by character
Externí odkaz:
https://doaj.org/article/0b6acc71c4354e2bbd0269c99c9cf16b