Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection

Autor: Alvaro Baeza Garcia, Edwin Siu, Tiffany Sun, Valerie Exler, Luis Brito, Armin Hekele, Gib Otten, Kevin Augustijn, Chris J. Janse, Jeffrey B. Ulmer, Jürgen Bernhagen, Erol Fikrig, Andrew Geall, Richard Bucala

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Plasmodium species produce an ortholog of the cytokine macrophage migration inhibitory factor, PMIF, which modulates the host inflammatory response to malaria. Here, the authors show that inhibition of PMIF may have translational benefits for managin

Externí odkaz: https://doaj.org/article/be49eab245d7481c9136ee80bc91bed8

Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection

Autor: Richard Bucala, Edwin Siu, Luis Brito, Tiffany Sun, Erol Fikrig, Jürgen Bernhagen, Chris J. Janse, Armin Hekele, Alvaro Baeza Garcia, Andrew Geall, Valerie Exler, Kevin D. Augustijn, Jeffrey B. Ulmer, Gib Otten

Publikováno v: Nature Communications, 9
Baeza Garcia, A, Siu, E, Sun, T, Exler, V, Brito, L, Hekele, A, Otten, G, Augustijn, K D, Janse, C, Ulmer, J, Bernhagen, J, Fikrig, E, Geall, A & Bucala, R 2018, ' Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection. ', Nature Communications, vol. 9, no. 2714, PMID: 30006528 . https://doi.org/10.1038/s41467-018-05041-7
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications, 9(2714):PMID: 30006528. Nature Publishing Group
Nature Communications 9, 2714 (2018). doi:10.1038/s41467-018-05041-7

Plasmodium species produce an ortholog of the cytokine macrophage migration inhibitory factor, PMIF, which modulates the host inflammatory response to malaria. Using a novel RNA replicon-based vaccine, we show the impact of PMIF immunoneutralization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61fd3de4c63bfeade62e5883c151f580
http://hdl.handle.net/1887/86669

Epithelial tight junction proteins as potential antibody targets for pancarcinoma therapy

Autor: Susanne Weinberger, Christian Itin, Peter Kufer, Birgit Kohleisen, Patrick A. Baeuerle, Sonja Offner, Armin Hekele, Ulrike Teichmann, Susanne Gross

Publikováno v: Cancer Immunology, Immunotherapy. 54:431-445

Recombinant monoclonal antibodies are beginning to revolutionize cancer therapy. In combination with standard chemotherapy, high response rates have been reported with antibodies of the human IgG1 isotype for treatment of non-Hodgkin's lymphoma and b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1913a160062f4394734497d3c5232bfb
https://doi.org/10.1007/s00262-004-0613-x

Rapidly produced SAM(®) vaccine against H7N9 influenza is immunogenic in mice

Autor: Luis Brito, John Gill, Gillis R. Otten, Scilla Buccato, Christian W. Mandl, Alessandra Bonci, Michela Brazzoli, Daniel G. Gibson, Rino Rappuoli, Armin Hekele, Andrew Geall, Ethan C. Settembre, Yuelong Shu, Daniele Casini, Jun Urano, Zhi-Qing Qi, Bolyn Hubby, George F. Gao, Jacob Archer, Giuseppe Palladino, Domenico Maione, J. Craig Venter, Nicky C. Caiazza, Philip R. Dormitzer, Peter W. Mason, Ennio De Gregorio, Sylvie Bertholet, Jeffrey B. Ulmer

Publikováno v: Emerging Microbes & Infections

The timing of vaccine availability is essential for an effective response to pandemic influenza. In 2009, vaccine became available after the disease peak, and this has motivated the development of next generation vaccine technologies for more rapid r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05618defbab6672aa750d2f2680f209f
https://pubmed.ncbi.nlm.nih.gov/26038486

Increasing incidence of CD44v7/8 epitope expression during uterine cervical carcinogenesis

Autor: Thomas Bauknecht, Peter Dall, Jürgen Moll, H. Ponta, Axel Göppinger, Peter Herrlich, Martin Hofmann, Armin Hekele, Albrecht Pfleiderer, Hans Ikenberg

Publikováno v: International Journal of Cancer. 69:79-85

Splice variants of the cell surface glycoprotein CD44 (CD44v) have been implicated in the progression of various human tumors. In the present study, we have examined the expression pattern of a CD44v epitope encoded by the adjacent variant exons v7 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a17b459d9f27ff429a315b992c9fbf1c
https://doi.org/10.1002/(sici)1097-0215(19960422)69:2<79::aid-ijc2>3.0.co