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Gradual loss of myelin and formation of an astrocytic scar during Wallerian degeneration in the human spinal cord

Autor: A. B. Schmitt, Jean Schoenen, Rachelle Franzen, Didier Martin, G. A. Brook, Byron Kakulas, Johannes Noth, Armin Buss

Publikováno v: Brain. 127:34-44

Axons undergo Wallerian degeneration distal to a point of injury. Experimental investigations have documented many of the cellular and molecular events that underlie this behaviour. Since relatively little is known about such events in human CNS path

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb4999c4ce13d3aa6aa525f7b74fcbe
https://doi.org/10.1093/brain/awh001

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Nogo-A Inhibits Neurite Outgrowth and Cell Spreading with Three Discrete Regions

Autor: Christian Brösamle, Lisa Schnell, Klemens Kaupmann, Thomas Oertle, Armin Buss, Martin E. Schwab, Anna Robeva, Marjan E. van der Haar, Christine E. Bandtlow, Rüdiger Vallon, Andrea B. Huber, Marjo Simonen, Patricia Burfeind

Publikováno v: The Journal of Neuroscience. 23:5393-5406

Nogo-A is a potent neurite growth inhibitorin vitroand plays a role both in the restriction of axonal regeneration after injury and in structural plasticity in the CNS of higher vertebrates. The regions that mediate inhibition and the topology of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::440bbfa520cdd7914d95f392e056659c
https://doi.org/10.1523/jneurosci.23-13-05393.2003

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Sequential loss of myelin proteins during Wallerian degeneration in the rat spinal cord

Autor: Martin E. Schwab, Armin Buss

Publikováno v: Glia. 42:424-432

Axotomy of nerve fibers leads to the subsequent degeneration of their distal part, a process termed Wallerian degeneration (WD). While WD in the peripheral nervous system is usually followed by regeneration of the lesioned axons, central nervous syst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058e0b49012e33f40a71d40d996f8eb5
https://doi.org/10.1002/glia.10220

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Functional polymorphisms in matrix metalloproteinases -1, -3, -9 and -12 in relation to cervical artery dissection

Autor: Sebastian Breuer, Susanne Roelver, Brunhilde Bloemeke, Armin Buss, Katrin Pech, Christoph Klotzsch

Publikováno v: BMC Neurology, Vol 9, Iss 1, p 40 (2009)
BMC neurology 9, 40 (2009). doi:10.1186/1471-2377-9-40
BMC Neurology

Background Cervical artery dissection is a leading cause of cerebral ischemia in young adults. Morphological investigations have shown alterations in the extracellular matrix (ECM) of affected vessel walls. As matrix metalloproteinases (MMP) play a c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::258543744e3ef40ccfa28ed36b9ba891
http://www.biomedcentral.com/1471-2377/9/40

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NG2 and phosphacan are present in the astroglial scar after human traumatic spinal cord injury

Autor: Jean Schoenen, Johannes Noth, Didier Martin, Gary A. Brook, Armin Buss, Byron Kakulas, Katrin Pech

Publikováno v: BMC neurology 9(32), (2009). doi:10.1186/1471-2377-9-32
BMC Neurology, Vol 9, Iss 1, p 32 (2009)
BMC Neurology

Background A major class of axon growth-repulsive molecules associated with CNS scar tissue is the family of chondroitin sulphate proteoglycans (CSPGs). Experimental spinal cord injury (SCI) has demonstrated rapid re-expression of CSPGs at and around

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e9999322d31a869358151afbe51231
https://doi.org/10.1186/1471-2377-9-32

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Acute rolipram/thalidomide treatment improves tissue sparing and locomotion after experimental spinal cord injury

Autor: Ronald Deumens, Aye Mu Myint, Liam Geoghegan, Johannes Noth, Gary A. Brook, Wiel H H Honig, Nadine Kern, Armin Buss, Elbert A.J. Joosten, Guido C Koopmans

Publikováno v: Experimental neurology. 216(2)

Traumatic spinal cord injury (SCI) causes severe and permanent functional deficits due to the primary mechanical insult followed by secondary tissue degeneration. The cascade of secondary degenerative events constitutes a range of therapeutic targets

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d45978775dda161d55684d2e7ac1e16
https://pubmed.ncbi.nlm.nih.gov/19320007

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TGF-beta1 and TGF-beta2 expression after traumatic human spinal cord injury

Autor: Didier Martin, Johannes Noth, Gary A. Brook, Armin Buss, Katrin Pech, Byron Kakulas, Jean Schoenen

Publikováno v: Spinal cord. 46(5)

Immunohistochemical investigation in control and lesioned human spinal cords.To assess the spatial and temporal expression patterns of transforming growth factor-beta1 and -beta2 (TGF-beta1 and TGF-beta2) in the human spinal cord after traumatic inju

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e324620ff73a96f2fd9ffdc7e9e23344
https://pubmed.ncbi.nlm.nih.gov/18040277

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Matrix metalloproteinases and their inhibitors in human traumatic spinal cord injury

Autor: Johannes Noth, Didier Martin, Gary A. Brook, Jean Schoenen, Armin Buss, Katrin Pech, Byron Kakulas

Publikováno v: BMC Neurology
BMC neurology 7, 17 (2007). doi:10.1186/1471-2377-7-17
BMC Neurology, Vol 7, Iss 1, p 17 (2007)

Background Matrix metalloproteinases (MMPs) are a family of extracellular endopeptidases that degrade the extracellular matrix and other extracellular proteins. Studies in experimental animals demonstrate that MMPs play a number of roles in the detri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4ff432f9b0f0c699c539b13e232de8
https://doi.org/10.1186/1471-2377-7-17

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Growth-modulating molecules are associated with invading Schwann cells and not astrocytes in human traumatic spinal cord injury

Autor: Johannes Noth, Armin Buss, Gary A. Brook, Didier Martin, Katrin Pech, Byron Kakulas, Jean Schoenen

Publikováno v: Brain : a journal of neurology. 130(Pt 4)

Despite considerable progress in recent years, the underlying mechanisms responsible for the failure of axonal regeneration after spinal cord injury (SCI) remain only partially understood. Experimental data have demonstrated that a major impediment t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a2bdb359ab9df31341adc227401b2ef
https://pubmed.ncbi.nlm.nih.gov/17314203

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Correlation of postmortem 9.4 tesla magnetic resonance imaging and immunohistopathology of the human thoracic spinal cord 7 months after traumatic cervical spine injury

Autor: Jan Gelan, Gary A. Brook, Félix Scholtes, Byron Kakulas, Peter Adriaensens, Jean Schoenen, Didier Martin, Emile A. M. Beuls, Liesbet Storme, Armin Buss

Publikováno v: Neurosurgery. 59(3)

OBJECTIVE: To correlate high-resolution magnetic resonance imaging (MRI) with immunohistopathology in the injured human spinal cord. METHODS: Postmortem MRI scans at a field strength of 9.4 T, as well as standard histology and immunohistochemistry, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a0c71e16c88a5f104945d1f6f16ef7f
https://pubmed.ncbi.nlm.nih.gov/16955049

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