Výsledky vyhledávání - "Armin Reichenberg"

Akademický článek

Fosmidomycin uptake into Plasmodium and Babesia-infected erythrocytes is facilitated by parasite-induced new permeability pathways.

Autor: Stefan Baumeister, Jochen Wiesner, Armin Reichenberg, Martin Hintz, Sven Bietz, Omar S Harb, David S Roos, Maximilian Kordes, Johannes Friesen, Kai Matuschewski, Klaus Lingelbach, Hassan Jomaa, Frank Seeber

Publikováno v: PLoS ONE, Vol 6, Iss 5, p e19334 (2011)

BackgroundHighly charged compounds typically suffer from low membrane permeability and thus are generally regarded as sub-optimal drug candidates. Nonetheless, the highly charged drug fosmidomycin and its more active methyl-derivative FR900098 have p

Externí odkaz: https://doaj.org/article/c4027a7c21c4431683f79eb680d83406

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FR-900098, an antimalarial development candidate that inhibits the non-mevalonate isoprenoid biosynthesis pathway, shows no evidence of acute toxicity and genotoxicity

Autor: Hassan Jomaa, Armin Reichenberg, Martin Schlitzer, Martin Hintz, Andreas Vilcinskas, Jochen Wiesner, Christina Ziemann, Regina Ortmann, Nina Timmesfeld, Rainer Fuhst

Publikováno v: Virulence

FR-900098 is an inhibitor of 1-deoxy-d-xylulose-5-phosphate (DXP) reductoisomerase, the second enzyme in the non-mevalonate isoprenoid biosynthesis pathway. In previous studies, FR-900098 was shown to possess potent antimalarial activity in vitro and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::715c513d17301551301f2677a117fe3f
https://publica.fraunhofer.de/handle/publica/246071

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Towards New Antimalarial Drugs: Synthesis of Non-Hydrolyzable Phosphate Mimics as Feed for a Predictive QSAR Study on 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase Inhibitors

Autor: Hassan Jomaa, Andreas Link, Claus Weidemeyer, Dirk Gießmann, Silke Sanderbrand, Serge Van Calenbergh, Philipp Heidler, Timothy Haemers, Armin Reichenberg, Jochen Wiesner

Publikováno v: Chemistry & Biodiversity. 5:643-656

The conversion of 1-deoxy-D-xylulose-5-phosphate (DOXP) to 2-C-methyl-D-erythritol-4-phosphate (MEP) is effectively blocked by 1-deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr) inhibitors such as the natural antibiotic fosmidomycin. Prediction of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8a1052ed56e763923c48404e1626ab2
https://doi.org/10.1002/cbdv.200890060

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Prolonged (E)-4-Hydroxy-3-Methyl-But-2-Enyl Pyrophosphate-Driven Antimicrobial and Cytotoxic Responses of Pulmonary and Systemic Vγ2Vδ2 T Cells in Macaques

Autor: Zheng W. Chen, Armin Reichenberg, Martin Hintz, Lisa Halliday, Zahida Ali, Lingyun Shao, Hassan Jomaa

Publikováno v: The Journal of Immunology. 179:8287-8296

Although phosphoantigen-specific Vγ2Vδ2 T cells appear to play a role in antimicrobial and anticancer immunity, mucosal immune responses and effector functions of these γδ T cells during infection or phospholigand treatment remain poorly characte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51021b5033e63d6bf87fbac5991cfa24
https://doi.org/10.4049/jimmunol.179.12.8287

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Acyloxyalkyl ester prodrugs of FR900098 with improved in vivo anti-malarial activity

Autor: Regina Ortmann, Ewald Beck, Jochen Wiesner, Armin Reichenberg, Martin Schlitzer, Dajana Henschker, Hassan Jomaa

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 13:2163-2166

FR900098 represents an improved derivative of the new antimalarial drug fosmidomycin and acts through inhibition of the 1-deoxy-D-xylulose 5-phosphate (DOXP) reductoisomerase, an essential enzyme of the mevalonate independent pathway of isoprenoid bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8f6b94518502337fc9c51d71e6728df
https://doi.org/10.1016/s0960-894x(03)00354-8

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Replacing the pyrophosphate group of HMB-PP by a diphosphonate function abrogates Its potential to activate human γδ T cells but does not lead to competitive antagonism

Autor: Tanja Kuhl, Armin Reichenberg, Hassan Jomaa, Christian Haug, Jens Moll, Rosel Engel, D. N. Ostrovsky, Martin Hintz, Yvonne Kletschek, Matthias Eberl

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 13:1257-1260

The immunological characterization of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP), and its methylenediphosphonate analogue, HMB-PCP, is described. With an EC(50) of 0.1-0.2 nM, HMB-PP is significantly more potent in stimulating human Vga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7bbf893c4abc6f34ece9be6ed3f0f4f
https://doi.org/10.1016/s0960-894x(03)00138-0

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LytB protein catalyzes the terminal step of the 2-C-methyl-D-erythritol-4-phosphate pathway of isoprenoid biosynthesis

Autor: Jochen Wiesner, Boran Altincicek, Ann-Kristin Kollas, Evert C. Duin, Reiner Hedderich, Stefanie Wagner, Hassan Jomaa, Ewald Beck, Martin Hintz, Armin Reichenberg

Publikováno v: FEBS Letters. 532:437-440

Recombinant LytB protein from the thermophilic eubacterium Aquifex aeolicus produced in Escherichia coli was purified to apparent homogeneity. The purified LytB protein catalyzed the reduction of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a04bde136b49e05bf6628b6be5a89f
https://doi.org/10.1016/s0014-5793(02)03726-2

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Accumulation of a potent gammadelta T-cell stimulator after deletion of the lytB gene in Escherichia coli

Autor: Armin Reichenberg, Jochen Wiesner, Hassan Jomaa, Ute Bahr, Silke Sanderbrand, Donald C. Foster, Matthias Eberl, Boran Altincicek, Ann-Kristin Kollas, Ewald Beck, Martin Hintz

Publikováno v: Immunology. 106:200-211

Activation of human Vgamma9/Vdelta2 T cells by many pathogens depends on the presence of small phosphorylated non-peptide compounds derived from the 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway of isoprenoid biosynthesis. We here demonstrate tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e65a1c83706e46e71990757231a41e
https://doi.org/10.1046/j.1365-2567.2002.01414.x

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Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human γδ T cells inEscherichia coli

Autor: Ruth M. Gschwind, Jochen Wiesner, Matthias Eberl, Boran Altincicek, Ewald Beck, Ann-Kristin Kollas, Armin Reichenberg, Hassan Jomaa, Martin Hintz, Ute Bahr

Publikováno v: FEBS Letters. 509:317-322

The gcpE and lytB gene products control the terminal steps of isoprenoid biosynthesis via the 2-C-methyl-D-erythritol 4-phosphate pathway in Escherichia coli. In lytB-deficient mutants, a highly immunogenic compound accumulates significantly, compare

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7d53ea2789c1fadd653177d3768e60d
https://doi.org/10.1016/s0014-5793(01)03191-x

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Fosmidomycin as an Antimalarial Agent

Autor: David B. Hutchinson, Martin Hintz, Serge Van Calenbergh, Hassan Jomaa, Steffen Borrmann, Jochen Wiesner, Bertrand Lell, Regina Ortmann, Martin Schlitzer, Armin Reichenberg, Peter G. Kremsner

Publikováno v: Isoprenoid Synthesis in Plants and Microorganisms ISBN: 9781461440628

The isoprenoid biosynthesis of Plasmodium falciparum, the causative agent of malignant tertiana malaria, solely depends on the mevalonate-independent 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway [also known as the 1-deoxy-d-xylulose 5-phosphate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f577419b836c32ab9588a5f831a99b3a
https://doi.org/10.1007/978-1-4614-4063-5_9

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