Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Armin, Schultz"'
Autor:
Toby M. Maher, Christina Schlecker, Doreen Luedtke, Sebastian Bossert, Donald F. Zoz, Armin Schultz
Publikováno v:
ERJ Open Research, Vol 8, Iss 4 (2022)
Introduction BI 1015550 is a phosphodiesterase 4 (PDE4) inhibitor that has antifibrotic properties. Phase I and Ic studies were conducted to investigate the safety, tolerability and pharmacokinetics of BI 1015550 in healthy male subjects and patients
Externí odkaz:
https://doaj.org/article/21b9b0816508498c90339a882a036afe
Autor:
Timothy, Tyler, Armin, Schultz, Alessio, Venturini, Claudio, Giuliano, Alberto, Bernareggi, Riccardo, Spezia, Daniel, Voisin, Valentino, Stella
Publikováno v:
Clinical Pharmacology in Drug Development. 11:1405-1418
Oral NEPA is the fixed-combination antiemetic comprising netupitant (neurokinin-1 receptor antagonist [NK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bab865f819f12bc8a33a32ad36f41d2
https://doi.org/10.1002/cpdd.1183
https://doi.org/10.1002/cpdd.1183
Autor:
Thomas Forst, Isabel Botz, Matthias Berse, Stephan Voswinkel, Mares-Elaine Strempler, Sybille Baumann, Armin Schultz
Background: The incidence of non-alcoholic fatty liver disease (NAFLD) is rising in parallel with increasing bodyweight and loss of glucose control, implicating a high risk of hepatic and extra-hepatic complications. Subjects / Methods: This longitud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d7fb88ac711edf26df064c8dbe1b634
https://doi.org/10.21203/rs.3.rs-2393464/v2
https://doi.org/10.21203/rs.3.rs-2393464/v2
Autor:
Thomas Forst, Isabel Botz, Matthias Berse, Stephan Voswinkel, Mares-Elaine Strempler, Sybille Baumann, Armin Schultz
Background: The incidence of metabolic dysfunction- associated fatty liver disease (MAFLD) is rising in parallel with increasing bodyweight and loss of glucose control, implicating a high risk of hepatic and extra-hepatic complications. Subjects / Me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a655240b95f38ae598a91c72a17ed1e5
https://doi.org/10.21203/rs.3.rs-2393464/v1
https://doi.org/10.21203/rs.3.rs-2393464/v1
Autor:
Armin Schultz, Stefanie Kapsa, Stefanie Boxnick, Uwe Thuss, Sigrun Unger, Christiane Otto, Frank Schaumann
Publikováno v:
Clinical Pharmacology in Drug Development. 11:296-308
The α2C -adrenoreceptor antagonist BAY 1193397 is in development for the oral treatment of diabetic foot ulcers. Safety, tolerability, and pharmacokinetics of BAY 1193397 were investigated in 3 randomized, single-center phase 1 studies in healthy ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e2cf49233af3a0a82d70ec6c59d140c
https://doi.org/10.1002/cpdd.1018
https://doi.org/10.1002/cpdd.1018
Autor:
John L. Perez, Isabel Vogler, Evelyna Derhovanessian, Gábor Boros, David A. Cooper, Camila R. Fontes-Garfias, Kristen E. Pascal, Armin Schultz, Alexander Muik, Martin Bexon, Pei Yong Shi, Peter Koch, Ann Kathrin Eller, Verena Lörks, Mark Cutler, Daniel Maurus, Ludwig Heesen, Philip R. Dormitzer, Ugur Sahin, Kathrin U. Jansen, Manuel Tonigold, Jan Grützner, Azita J. Mahiny, Corinna Rosenbaum, Stefanie Bolte, Mathias Vormehr, Marie Cristine Kühnle, Sybille Baumann, Asaf Poran, Alexander Ulges, Alexandra Kemmer-Brück, Christos A. Kyratsous, Dirk Becker, Özlem Türeci, Alina Baum, Sebastian Brachtendorf, Lena M. Kranz, Carsten Boesler, Rolf Hilker, Tania Palanche, Julian Sikorski, Nicole Bidmon, Ulrich Luxemburger, David J. Langer, Jesse Z. Dong, Gábor Szabó, Jasmin Quandt, Katalin Karikó, Jonas Reinholz
Publikováno v:
Nature. 595:572-577
BNT162b2, a lipid nanoparticle (LNP) formulated nucleoside-modified messenger RNA (mRNA) that encodes the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike glycoprotein (S) stabilized in the prefusion conformation, has demonstrated 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0154147b441b18af735efb00657c62f
https://doi.org/10.1038/s41586-021-03653-6
https://doi.org/10.1038/s41586-021-03653-6
Autor:
Toby M, Maher, Christina, Schlecker, Doreen, Luedtke, Sebastian, Bossert, Donald F, Zoz, Armin, Schultz
IntroductionBI 1015550 is a phosphodiesterase 4 (PDE4) inhibitor that has antifibrotic properties. Phase I and Ic studies were conducted to investigate the safety, tolerability and pharmacokinetics of BI 1015550 in healthy male subjects and patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc33ee0552be7587e3a47357d3f4ec9
http://hdl.handle.net/10044/1/100466
http://hdl.handle.net/10044/1/100466
Autor:
Mary Flack, Sabrina Wiebe, Armin Schultz, Jianan Hui, Meera Ramanujam, Elliott Klein, Jürgen Steffgen, Alpana Gupta, Christian Harcken, Jing Wu, Xiujiang Li, Steven J. Padula, Sudha Visvanathan, Ewald Benediktus, Tobias Litzenburger, Fabian Müller, Andreas Hünnemeyer
Publikováno v:
British Journal of Clinical Pharmacology. 87:1824-1838
Aims To evaluate the safety, pharmacokinetics and pharmacodynamics of single- and multiple-rising doses (MRDs) of BI 705564 and establish proof of mechanism. Methods BI 705564 was studied in 2 placebo-controlled, Phase I clinical trials testing singl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88ebde33657aca0b816d5b9c1eecde84
https://doi.org/10.1111/bcp.14571
https://doi.org/10.1111/bcp.14571
Autor:
Rolf Hilker, Jasmin Quandt, Boris Fischer, Jan Grützner, Kena A. Swanson, Sebastian Brachtendorf, Julian Sikorski, Mark Cutler, Kristen E. Pascal, Alexandra Kemmer-Brück, Lena M. Kranz, Dirk Becker, Katalin Karikó, Philip R. Dormitzer, Corinna Rosenbaum, Ulrich Luxemburger, Tania Palanche, Ugur Sahin, Camila R. Fontes-Garfias, Özlem Türeci, David A. Cooper, Armin Schultz, Alexander Muik, Ingrid L. Scully, Marie Cristine Kühnle, Jakob Loschko, Pei Yong Shi, Warren Kalina, Daniel Maurus, Verena Lörks, David J. Langer, Stefanie Bolte, Isabel Vogler, Mathias Vormehr, Christos A. Kyratsous, Carsten Boesler, Ann Kathrin Eller, Martin Bexon, Alina Baum, John L. Perez, Kathrin U. Jansen, Evelyna Derhovanessian
Publikováno v:
Nature
An effective vaccine is needed to halt the spread of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic. Recently, we reported safety, tolerability and antibody response data from an ongoing placebo-controlled, observer-blinded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e759c17cfd365c57e05fc7d355e9a4f
https://doi.org/10.1038/s41586-020-2814-7
https://doi.org/10.1038/s41586-020-2814-7
Autor:
Patricia N. Sidharta, Shirin Bruderer, Susanne Globig, James Carlson, Dénes Csonka, Mariya Antonova, Simon Grill, Armin Schultz
Publikováno v:
British Journal of Clinical Pharmacology
Aims To demonstrate the bioequivalence of macitentan/tadalafil fixed-dose combination (FDC) tablets with single-component tablets of macitentan and tadalafil in healthy subjects. Methods Studies AC-077-101 and AC-077-103 were single-centre, open-labe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32de39e54ed0a875d03df166760e14c2
https://doi.org/10.1111/bcp.14347
https://doi.org/10.1111/bcp.14347