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Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling

Autor: Cao, Jian, Boatner, Lisa M, Desai, Heta S, Burton, Nikolas R, Armenta, Ernest, Chan, Neil J, Castellón, José O, Backus, Keriann M

Publikováno v: Analytical chemistry, vol 93, iss 4

Mass-spectrometry-based chemoproteomics has enabled the rapid and proteome-wide discovery of functional and potentially 'druggable' hotspots in proteins. While numerous transformations are now available, chemoproteomic studies still rely overwhelming

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::62c74992371e9ca037bab9bc7efa7de2
https://escholarship.org/uc/item/6z47571v

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Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling.

Autor: Cao J; Department of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, United States., Boatner LM; Department of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, United States.; Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095, United States., Desai HS; Department of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, United States.; Molecular Biology Institute, UCLA, Los Angeles, California 90095, United States., Burton NR; Department of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, United States.; Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095, United States., Armenta E; Department of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, United States.; Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095, United States., Chan NJ; Department of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, United States.; Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095, United States., Castellón JO; Department of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, United States.; Molecular Biology Institute, UCLA, Los Angeles, California 90095, United States., Backus KM; Department of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, United States.; Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095, United States.; Molecular Biology Institute, UCLA, Los Angeles, California 90095, United States.; DOE Institute for Genomics and Proteomics, UCLA, Los Angeles, California 90095, United States.; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California 90095, United States.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, California 90095, United States.

Publikováno v: Analytical chemistry [Anal Chem] 2021 Feb 02; Vol. 93 (4), pp. 2610-2618. Date of Electronic Publication: 2021 Jan 20.