Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Armen Y Mulkidjanian"'
Autor:
Daria N Shalaeva, Dmitry A Cherepanov, Michael Y Galperin, Andrey V Golovin, Armen Y Mulkidjanian
Publikováno v:
eLife, Vol 7 (2018)
The ubiquitous P-loop fold nucleoside triphosphatases (NTPases) are typically activated by an arginine or lysine ‘finger’. Some of the apparently ancestral NTPases are, instead, activated by potassium ions. To clarify the activation mechanism, we
Externí odkaz:
https://doaj.org/article/209f25b647a34169a4466463c89b1b5a
Autor:
Philipp S Orekhov, Daniel Klose, Armen Y Mulkidjanian, Konstantin V Shaitan, Martin Engelhard, Johann P Klare, Heinz-Jürgen Steinhoff
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 10, p e1004561 (2015)
Motile bacteria and archaea respond to chemical and physical stimuli seeking optimal conditions for survival. To this end transmembrane chemo- and photoreceptors organized in large arrays initiate signaling cascades and ultimately regulate the rotati
Externí odkaz:
https://doaj.org/article/0ee02973b80846c9887aad445e5233e9
Autor:
Alexander A. Malär, Nino Wili, Laura A. Völker, Maria I. Kozlova, Riccardo Cadalbert, Alexander Däpp, Marco E. Weber, Johannes Zehnder, Gunnar Jeschke, Hellmut Eckert, Anja Böckmann, Daniel Klose, Armen Y. Mulkidjanian, Beat H. Meier, Thomas Wiegand
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Here, the authors use solid-state NMR and EPR measurements to characterise the ATP hydrolysis transition state of the oligomeric bacterial DnaB helicase from Helicobacter pylori, which was trapped by using aluminium fluoride as a chemical mimic. They
Externí odkaz:
https://doaj.org/article/eb891282fac642d58cd86a545184715e
Autor:
Philipp S. Orekhov, Marine E. Bozdaganyan, Natalia Voskoboynikova, Armen Y. Mulkidjanian, Maria G. Karlova, Anna Yudenko, Alina Remeeva, Yury L. Ryzhykau, Ivan Gushchin, Valentin I. Gordeliy, Olga S. Sokolova, Heinz-Jürgen Steinhoff, Mikhail P. Kirpichnikov, Konstantin V. Shaitan
Publikováno v:
Nanomaterials, Vol 12, Iss 3, p 361 (2022)
Amphiphilic copolymers consisting of alternating hydrophilic and hydrophobic units account for a major recent methodical breakthrough in the investigations of membrane proteins. Styrene–maleic acid (SMA), diisobutylene–maleic acid (DIBMA), and re
Externí odkaz:
https://doaj.org/article/a167d1deab034ef9be66ba5862c0bb35
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 24, p 13480 (2021)
In humans, over-activation of innate immunity in response to viral or bacterial infections often causes severe illness and death. Furthermore, similar mechanisms related to innate immunity can cause pathogenesis and death in sepsis, massive trauma (i
Externí odkaz:
https://doaj.org/article/0cedc9cbc8bb4bc4800f5f54d8bac14b
Autor:
Daria V. Dibrova, Kirill A. Konovalov, Vadim V. Perekhvatov, Konstantin V. Skulachev, Armen Y. Mulkidjanian
Publikováno v:
Biology Direct, Vol 12, Iss 1, Pp 1-11 (2017)
Abstract Background The Clusters of Orthologous Groups (COGs) of proteins systematize evolutionary related proteins into specific groups with similar functions. However, the available databases do not provide means to assess the extent of similarity
Externí odkaz:
https://doaj.org/article/171e160e6f454fd794c6b493fde6cdf0
Autor:
Olesya I. Klimchuk, Kirill A. Konovalov, Vadim V. Perekhvatov, Konstantin V. Skulachev, Daria V. Dibrova, Armen Y. Mulkidjanian
Publikováno v:
Biology Direct, Vol 12, Iss 1, Pp 1-7 (2017)
Abstract Background In prokaryotic genomes, functionally coupled genes can be organized in conserved gene clusters enabling their coordinated regulation. Such clusters could contain one or several operons, which are groups of co-transcribed genes. Th
Externí odkaz:
https://doaj.org/article/2572dc15872a4fc1883e8320e4992e60
Autor:
Natalia Voskoboynikova, Wageiha Mosslehy, Alexandr Colbasevici, Dmitry V. Bagrov, Philipp S. Orekhov, Marine E. Bozdaganyan, Armen Y. Mulkidjanian, Konstantin V. Shaitan
Publikováno v:
International Journal of Biomedicine, Vol 9, Iss Suppl_1, Pp S21-S21 (2019)
Background: The membrane-embedded 2:2 sensory rhodopsin II/transducer complex, NpSRII/NpHtrII, plays a key role in the photophobic response of the halophilic archaeon Natronomonas pharaonis. Photon absorption induces transient structural changes in t
Externí odkaz:
https://doaj.org/article/026f6bf09e764a83b6581793b8132acc
Publikováno v:
Biomolecules; Volume 12; Issue 10; Pages: 1346
To clarify the obscure hydrolysis mechanism of ubiquitous P-loop-fold nucleoside triphosphatases (Walker NTPases), we analysed the structures of 3136 catalytic sites with bound Mg-NTP complexes or their analogues. Our results are presented in two art
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f2555538e557ada1e2bb14d14e3b82
https://pubmed.ncbi.nlm.nih.gov/36291556
https://pubmed.ncbi.nlm.nih.gov/36291556
Although P-loop fold nucleoside triphosphatases (also known as Walker NTPases) are ubiquitous, their catalytic mechanism remains obscure. Based on a comparative structural analysis of 3136 Mg-NTP-containing catalytic sites, we propose a common scheme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56ebad826ce72500a58e28465efdbdc2
https://doi.org/10.1101/2022.06.23.497301
https://doi.org/10.1101/2022.06.23.497301
