Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Armen M. Boldi"'
Autor:
Armen M Boldi
Publikováno v:
Current Opinion in Chemical Biology. 8:281-286
Natural products are an attractive source of varied structures that exhibit potent biological activities, and desirable pharmacological profiles. Since the relatively recent advent of high-throughput organic synthesis in the drug discovery process, s
Publikováno v:
Journal of Combinatorial Chemistry. 3:367-373
The library synthesis of alkoxyprolines was achieved using an acid-stable, nucleophile-cleavable solid support. A hydroxythiophenol linker derived from Merrifield resin was esterified with the corresponding ethers of BOC-hydroxyproline. Removal of th
Autor:
Qiyan Lin, Kiyoshi Nakayama, William H. Moser, Noriaki Murase, Mark D. McBriar, Linghang Zhuang, Masao Sobukawa, Victoria A. Doughty, Armen M. Boldi, Amos B. Smith
Publikováno v:
Angewandte Chemie. 113:197-201
Publikováno v:
Tetrahedron Letters. 40:619-622
The solid-phase library synthesis of triazolopyridazines was accomplished using a [4+2] cycloaddition strategy. The Horner-Wadsworth-Emmons (HWE) reagent diethylphosphonoacetic acid was attached to the N-terminus of amino acids on Rink amide solid-ph
Autor:
Qiyan Lin, Kiyoshi Nakayama, Patrick R. Verhoest, Christopher S. Brook, Noriaki Murase, Mark D. McBriar, Linghang Zhuang, Armen M. Boldi, William H. Moser, Amos B. Smith
Publikováno v:
Tetrahedron Letters. 38:8667-8670
In this Letter, the first in a series of three, we outline our overall strategy and describe the assembly of a C(29–48) EF-ring advanced intermediate for the total synthesis of the spongistatins, rare and structurally unique polyether macrolides wi
Autor:
Quyan Lin, Armen M. Boldi, Christopher S. Brook, Kiyoshi Nakayama, William H. Moser, Amos B. Smith, Mark D. McBriar, Linghang Zhuang, Masao Sobukawa
Publikováno v:
Tetrahedron Letters. 38:8675-8678
A convergent synthesis of the C(1–17) AB-ring subunit of the spongistatins, exceedingly scarce and highly antimitotic polyether macrolides, has been achieved via a one-flask dithiane bisalkylation, stereocontrolled spiroketalization, and Julia sulf
Autor:
Christopher S. Brook, Qiyan Lin, Armen M. Boldi, Linghang Zhuang, Amos B. Smith, Robert E. Lee Trout, William H. Moser
Publikováno v:
Tetrahedron Letters. 38:8671-8674
The C(18–28) CD-ring spiroketal subunit of the spongistatins, marine polyether macrolides with unprecedented antitumor activity, has been generated via a highly convergent and completely stereocontrolled sequence. Key operations include a one-flask
Autor:
John E. Anthony, François Diederich, Jean-Paul Gisselbrecht, Carolyn B. Knobler, Corinne Boudon, Volker Gramlich, Armen M. Boldi, Maurice Gross
Publikováno v:
Helvetica Chimica Acta. 78:779-796
Derivatives of fully cross-conjugated tetraethynylethene (3,4-diethynylhex-3-ene-1,5-diyne) 1 are versatile precursors to multinanometer-sized molecular rods with all-C-backbones. Oxidative polymerization (CuCl, N,N,N′,N′-tetramethylethylenthylen
Autor:
John E. Anthony, Corinne Boudon, Carolyn B. Knobler, Jean-Paul Gisselbrecht, François Diederich, Maurice Gross, Paul Seiler, Armen M. Boldi
Publikováno v:
Helvetica Chimica Acta. 78:797-817
Tetraethynylethene (3,4-diethynylhex-3-ene-1,5-diyne) molecular scaffolding provided access to novel macrocyclic nanometer-sized C-rich molecules with unusual structural and electronic properties. Starting from cis-bis-deprotected cis-bis(trialkylsil
Autor:
John E. Anthony, François Diederich, Paul Seiler, Armen M. Boldi, Markus Hobi, Carolyn B. Knobler, Volker Gramlich, Yves Rubin
Publikováno v:
Helvetica Chimica Acta. 78:13-45
The preparation of tetraethynylethene (3,4-diethynylhex-3-ene-1,5-diyne) 1 as well as of a great diversity of differentially mono-, di-, and triprotected derivatives by newly developed synthetic routes is described. These fully cross-conjugated molec