Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Armando Urbina"'
Publikováno v:
Plasmonics: Design, Materials, Fabrication, Characterization, and Applications XX.
Autor:
Ian B. Moses, Rick Rodriguez, Peter Robert Rose, Corey L. Stanchina, Cuthbertson Timothy J, Asayuki Kamatani, Pieter D. de Koning, Alison Sandoval, Kyle Kissick, Robert Moore, Leera Rahman, Douglas McAndrew, Armando Urbina, David C. Boyles
Publikováno v:
Organic Process Research & Development. 15:1018-1026
A robust six-step process for the synthesis of crizotinib, a novel c-Met/ALK inhibitor currently in phase III clinical trials, has been developed and used to deliver over 100 kg of API. The process includes a Mitsunobu reaction, a chemoselective redu
Autor:
Nebojsa Stankovic, Armando Urbina, Sean Timothy Neville, and David Camp, Robert William Scott
Publikováno v:
Organic Process Research & Development. 10:296-303
The synthesis of N,2-dimethyl-6-(2-(1-methyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)benzo[b]thiophene-3-carboxamide (1, AG-28262) on kilogram scale is described. Initial syntheses of key components 2 and 3 worked well on laboratory scale but h