Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Armando Lagrutta"'
Autor:
Samuel Finkel, Shannon Sweet, Tyler Locke, Sydney Smith, Zhefan Wang, Christopher Sandini, John Imredy, Yufang He, Marc Durante, Armando Lagrutta, Adam Feinberg, Andrew Lee
Publikováno v:
APL Bioengineering, Vol 7, Iss 4, Pp 046113-046113-11 (2023)
There is critical need for a predictive model of human cardiac physiology in drug development to assess compound effects on human tissues. In vitro two-dimensional monolayer cultures of cardiomyocytes provide biochemical and cellular readouts, and in
Externí odkaz:
https://doaj.org/article/00e873fd13b6459ca2478cfdd2b67281
Autor:
Samuel Finkel, Shannon Sweet, Tyler Locke, Sydney Smith, Zhefan Wang, Christopher Sandini, John P. Imredy, Yufang He, Marc Durante, Armando Lagrutta, Adam Feinberg, Andrew Lee
There is critical need for a predictive model of human cardiac physiology in the drug development process for assessment of compound toxicology and pharmacology. In vitro two-dimensional monolayer culture of cardiomyocytes provides biochemical and ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8b5640a55677825ac4c560a3cc4b37b
https://doi.org/10.1101/2023.03.13.528447
https://doi.org/10.1101/2023.03.13.528447
Autor:
John P Imredy, Holly Clouse, Armando Lagrutta, Michael P Graziano, Krista M Durney, Wilson Hsieh, Jamie Gearhart, Brian Schriver, Nathan W Bay, Nicole T Feric
Publikováno v:
Circulation Research. 131
MK-8722, a systemic pan-AMPK activator improves glucose homeostasis in animal models of diabetes, but causes cardiac hypertrophy # . Two- and 3-dimensional tissue (2D,3D) constructs of human induced pluripotent stem cell derived cardiomyocytes (CM) (
Publikováno v:
Applied In Vitro Toxicology. 6:144-155
We reported that blockade of Ca2+ channel increased beating rate on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) when in hiPSC-CM culture media, but decreased beating rate...
Autor:
Nicolas Couvreur, Charles Benson, Jean-Michel Guillon, Yoshiko Okai, Armando Lagrutta, Todd Wisialowski, Michael G. Rolf, Ard Teisman, C. Michael Foley, Hugo M. Vargas, Jean-Pierre Valentin, Maki Ito, Michael J. Engwall, Khuram W. Chaudhary, Gary Gintant, David J. Gallacher, Takashi Yoshinaga, Andrea Greiter-Wilke, Corina Dota, Paul Levesque, Katsuyoshi Chiba, Amy Pointon, Stephen Jenkinson, Anthony Bahinski, Martin Traebert, Brian Guth, Eric Martel, Alan S. Bass, Christa Hegele‐Hartung, William E. Achanzar, Ravikumar Peri, Herbert M. Himmel, Yusheng Qu, Derek J. Leishman
Publikováno v:
Clinical Pharmacology and Therapeutics
Defining an appropriate and efficient assessment of drug‐induced corrected QT interval (QTc) prolongation (a surrogate marker of torsades de pointes arrhythmia) remains a concern of drug developers and regulators worldwide. In use for over 15 years
Publikováno v:
European Heart Journal. 42
Introduction Vericiguat is an orally-administered soluble guanylate cyclase stimulator, developed for the treatment of symptomatic chronic heart failure (HF) in adult patients who have had a previous decompensation event. At the maximum therapeutic d
Publikováno v:
Toxicological Sciences. 167:573-580
Calcium channel blockers (CCBs), such as diltiazem, nifedipine, and verapamil, cause tachycardia effects on several commercially available human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), when tested in culture media provided b
Publikováno v:
Toxicology and Applied Pharmacology. 430:115725
An effective in vitro screening assay to detect seizure liability in preclinical development can contribute to better lead molecule optimization prior to candidate selection, providing higher throughput and overcoming potential brain exposure limitat
Publikováno v:
JRSM Cardiovascular Disease, Vol 8 (2019)
Objective We investigated if there is IKs, and if there is repolarization reserve by IKs in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Design We used a specific KCNQ1/KCNE1 channel blocker, L-000768673, with an IC50 of 9
Autor:
Jennifer B. Pierson, Armando Lagrutta, Holly Clouse, Michael Furniss, Ivan Kopljar, Frederick Sannajust, Ralf Kettenhofen, Haoyu Zeng, Hua Rong Lu, Karel Van Ammel, Fetene Tekle, Ard Teisman, Jin Zhai, Liang Guo, David J. Gallacher
Publikováno v:
Toxicol Sci
The goal of this research consortium including Janssen, MSD, Ncardia, FNCR/LBR, and Health and Environmental Sciences Institute (HESI) was to evaluate the utility of an additional in vitro assay technology to detect potential drug-induced long QT and