Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Armando G. Villaseñor"'
Autor:
Qi Liu, Chien-Hung Chou, Eda Canales, Roman Sakowicz, Steven Bondy, Tomas Cihlar, Albert Liclican, Diana M. Brainard, Anita Niedziela-Majka, William Rowe, Nikolai Novikov, Shekeba Ahmadyar, John R. Somoza, Randall L. Halcomb, Cheryl K. McDonald, Carina E. Cannizzaro, Nicolas Margot, Debi Jin, George Stepan, Qiaoyin Wu, Eric Hu, Judy Mwangi, Stephanie A. Leavitt, Todd C. Appleby, Robert L. Anderson, Scott E. Lazerwith, Schroeder Scott D, Tse Winston C, Gediminas Brizgys, Rebecca Begley, Yili Xu, Scott Sellers, Scott A. Wolckenhauer, Wesley I. Sundquist, Derek Hansen, Philip Morganelli, Andrew Mulato, Sheila Clancy, Xiaohong Liu, Anna Chiu, Eric S. Daar, Renee R. Ram, S. Swaminathan, Anne E. Chester, Melanie H. Wong, Ya-Pei Liu, John O. Link, Michael Graupe, Luong K. Tsai, Christian Callebaut, Latesh Lad, William E. Lee, Rujuta A. Bam, Terrence Z. Cai, Bing Lu, John K. Ling, Roland D. Saito, Magdeleine Hung, Armando G. Villaseñor, Peter Ruane, Nikos Pagratis, Martin S. Rhee, David Koditek, Gordon Crofoot, Giuseppe A. Papalia, Stephen R. Yant, Rob Hyland, Helen Yu, Jim Zheng, Jennifer R. Zhang, Gary I. Sinclair, Jiayao Li, Eric Singer
Publikováno v:
Nature
Oral antiretroviral agents provide life-saving treatments for millions of people living with HIV, and can prevent new infections via pre-exposure prophylaxis1–5. However, some people living with HIV who are heavily treatment-experienced have limite
Autor:
Devleena Shivakumar, Uli Schmitz, Janet L. Paulsen, Todd C. Appleby, Daniel J. Sindhikara, Armando G. Villaseñor, Lingle Wang, Haoyu S. Yu
Publikováno v:
Journal of Chemical Information and Modeling. 60:3489-3498
A tremendous research and development effort was exerted toward combating chronic hepatitis C, ultimately leading to curative oral treatments, all of which are targeting viral proteins. Despite the advantage of numerous targets allowing for broad hep
Autor:
Kyla Ramey, Katana Ashley Anne, Kato Darryl, Tran Chinh Viet, Cheng Y. Yang, Link John O, Debi Jin, Yujin Wang, Kobayashi Tetsuya, Karki Kapil Kumar, Armando G. Villaseñor, Todd C. Appleby, Kelly Wang, Sangi Michael, Jeff Zablocki, Randy Vivian, Brian E. Schultz, Yang Zheng-Yu, Guofeng Cheng, Dustin Siegel, Zipfel Sheila, Ona Barauskas, James G. Taylor, Martinez Ruben, Katie Chan, Adam J. Schrier
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2428-2436
Treatment of hepatitis C virus (HCV) infection has been historically challenging due the high viral genetic complexity wherein there are eight distinct genotypes and at least 86 viral subtypes. While HCV NS3/4A protease inhibitors are an established
Autor:
Ruth Wang, Sarah Wise, Ben Niu, Todd C. Appleby, Michael L. Gross, Melanie Wong, Giuseppe A. Papalia, Jean-Philippe Belzile, Sheila Clancy, Latesh Lad, Armando G. Villaseñor, Johannes Voight, Mariya Morar, Katherine M. Brendza
Publikováno v:
Biochemistry
Blocking interactions between PD-1 and PD-L1 opens a new era of cancer treatment involving immunity modulation. Although most immunotherapies use monoclonal antibodies, small-molecule inhibitors offer advantages. To facilitate development of small-mo
Autor:
Gary Phillips, Leena Patel, Stephane Perreault, Jennifer Treiberg, Nicholas Alexander Till, Eve-Irene Lepist, Armando G. Villaseñor, Mary E. McGrath, David Koditek, Yelena Zherebina, John R. Somoza, Sedillo Kassandra F, Joshua Van Veldhuizen, Joseph Therrien, Ryan Dick, Jayaraman Chandrasekhar
Publikováno v:
Journal of Medicinal Chemistry. 61:6858-6868
Atropisomerism is a type of axial chirality in which enantiomers or diastereoisomers arise due to hindered rotation around a bond axis. In this manuscript, we report a case in which torsional scan studies guided the thoughtful creation of a restricte
Autor:
Gary Phillips, Nikolai Novikov, Kamal D. Puri, Mary E. McGrath, Leena Patel, Carmen Ip, Arthur Yeung, Latesh Lad, Kirk L. Stevens, Musong Kim, Eve-Irene Lepist, Armando G. Villaseñor, Jayaraman Chandrasekhar, Joseph Therrien, Joshua Kaplan, Jerry Evarts, John R. Somoza, Aaron C. Haran, David Koditek, Stephane Perreault, Bart H. Steiner, Jennifer Treiberg
Publikováno v:
Journal of Medicinal Chemistry. 59:3532-3548
Inhibition of phosphoinositide 3-kinase δ (PI3Kδ) is an appealing target for several hematological malignancies and inflammatory diseases. Herein, we describe the discovery and optimization of a series of propeller shaped PI3Kδ inhibitors comprisi
Autor:
Dharmaraj Samuel, John R. Somoza, Ruth Wang, Albert Liclican, Armando G. Villaseñor, Nikolai Novikov, Leanna Lagpacan, Giuseppe A. Papalia, Mary E. McGrath, Latesh Lad, David Koditek, Brian E. Schultz, Melanie H. Wong, Weimei Xing
Publikováno v:
The Journal of Biological Chemistry
Background: Idelalisib is a PI3Kδ inhibitor used to treat hematological malignancies. Results: Idelalisib is selective, noncovalent, reversible, and ATP-competitive. Conclusion: The crystal structure helps explain the potency and selectivity of idel
Autor:
Leanna Lagpacan, Christopher Allen Ziebenhaus, Bruno Marchand, Elfatih Elzein, Jason K. Perry, Bernard P. Murray, Scott Preston Simonovich, Parkhill Eric Q, Armando G. Villaseñor, WaiLok K. Hung, Nikos Pagratis, Rao Kalla, Jeff Zablocki, Dmitry Koltun, John R. Somoza, Timothy R. Hansen, Ron Aoyama, Thao Perry, Magdeleine Hung, Xiaofen Li
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(3)
We hereby disclose the discovery of inhibitors of CaMKII (7h and 7i) that are highly potent in rat ventricular myocytes, selective against hERG and other off-target kinases, while possessing good CaMKII tissue isoform selectivity (cardiac γ/δ vs. n
Autor:
Taygerly Joshua Paul Gergely, Eun Kyung Lee, Mcintosh Joel, Sarah C. Abbot, Jaehyeon Park, Sonal Rajyaguru, Yun-Chou Tan, Shalini Anand, Francisco Xavier Talamas, Sophie Le Pogam, Remy Lemoine, David S. Carter, Petra Inbar, Jun Chen, Leanna R. Staben, Armando G. Villaseñor, Javier de Vicente, Isabel Najera, Ryan Craig Schoenfeld, Leyi Gong, Seth F. Harris, Paul Weller, Sharada Shenvi Labadie, Ken A. Brameld, Aruna Railkar, Sangi Michael, Amy Fung, Jim Li, Vincent Leveque, Dana Davis
Publikováno v:
Journal of Medicinal Chemistry. 57:1914-1931
In the past few years, there have been many advances in the efforts to cure patients with hepatitis C virus (HCV). The ultimate goal of these efforts is to develop a combination therapy consisting of only direct-antiviral agents (DAAs). In this paper
Autor:
Todd C. Appleby, Ruth Wang, Magdeleine Hung, Brian E. Schultz, Roman Sakowicz, Armando G. Villaseñor, Giuseppe A. Papalia, Maile Velasquez, Xiaohong Liu, Victoria C. Smith, Andrew E. Greenstein, Hyock Joo Kwon, Melanie H. Wong, Albert Liclican
Publikováno v:
The Journal of biological chemistry. 292(16)
Matrix metalloproteinase 9 (MMP9) is a member of a large family of proteases that are secreted as inactive zymogens. It is a key regulator of the extracellular matrix, involved in the degradation of various extracellular matrix proteins. MMP9 plays a