Supplemental Figure S3 from On-Target Effect of FK866, a Nicotinamide Phosphoribosyl Transferase Inhibitor, by Apoptosis-Mediated Death in Chronic Lymphocytic Leukemia Cells

Autor: Versha Banerji, Spencer B. Gibson, James B. Johnston, Armando G. Poeppl, Sara Beiggi, Eric D.J. Bouchard, Iris Gehrke

Figure S3: Cells were treated for one, two or three days with FK866 at 1 nM, 10 nM and 50 nM. A) AMPK was phosphorylated at all concentrations at day 1, but only at 1 nM after three days incubation with FK866. B) mTOR was phosphorylated at 1 nM and 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae34f4c32bf56a4aee039f018045ee8
https://doi.org/10.1158/1078-0432.22454565.v1

Supplemental Figure S1 from On-Target Effect of FK866, a Nicotinamide Phosphoribosyl Transferase Inhibitor, by Apoptosis-Mediated Death in Chronic Lymphocytic Leukemia Cells

Autor: Versha Banerji, Spencer B. Gibson, James B. Johnston, Armando G. Poeppl, Sara Beiggi, Eric D.J. Bouchard, Iris Gehrke

Figure S1: Protein lysates from CLL cells (n=21), PBMCs (n=4) or purified B-cells (n=2) from control donors were subjected to immunoblotting. Band signal intensities were quantified by ImageJ software. Values were corrected for background and normali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0465899eacd9cbf97917ce42619edd94
https://doi.org/10.1158/1078-0432.22454571

Supplemental Table S2 from On-Target Effect of FK866, a Nicotinamide Phosphoribosyl Transferase Inhibitor, by Apoptosis-Mediated Death in Chronic Lymphocytic Leukemia Cells

Autor: Versha Banerji, Spencer B. Gibson, James B. Johnston, Armando G. Poeppl, Sara Beiggi, Eric D.J. Bouchard, Iris Gehrke

Table S2: The associations between patient characteristics (Table S1, columns 2 to 11), patient treatment (Tx) status (Table S1, column 12) and sensitivity to FK866 based on LD50 (Table S1, column 13) were measured using Fisher's Exact Test of Indepe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18fd6dcfffd019142d75747799c90c77
https://doi.org/10.1158/1078-0432.22454559.v1

Disruption of SIRPα signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts

Autor: Liqing Jin, Jayne S. Danska, Po-Yan Cheng, Nico van Rooijen, John E. Dick, Andrei V. Malko, Jenny M.-Y. Ho, Jean C.Y. Wang, Alexandre Theocharides, Tatiana K. Prasolava, Armando G. Poeppl, Mark D. Minden

Publikováno v: The Journal of Experimental Medicine
Theocharides, A P A, Jin, L Q, Cheng, P Y, Prasolava, T K, Malko, A V, Ho, J M, Poeppl, A G, van Rooijen, N, Minden, M D, Danska, J S, Dick, J & Wang, J C Y 2012, ' Disruption of SIRP alpha signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts ', Journal of Experimental Medicine, vol. 209, no. 10, pp. 1883-1899 . https://doi.org/10.1084/jem.20120502
Journal of Experimental Medicine, 209(10), 1883-1899. Rockefeller University Press

Inhibition of macrophage SIRPα–CD47 interactions mediates phagocytosis and clearance of acute myeloid leukemia stem cells.
Although tumor surveillance by T and B lymphocytes is well studied, the role of innate immune cells, in particular macr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcf376b90e0f05294f062fc9171d3f16
https://doi.org/10.1084/jem.20120502

Multiple Reduced-intensity Conditioning Regimens Facilitate Correction of Fabry Mice After Transplantation of Transduced Cells

Autor: Makoto Yoshimitsu, Jeffrey A. Medin, Sheng-Ben Liang, Vanessa I. Rasaiah, Jianhui Cai, Daniel H. Fowler, Armando G. Poeppl

Publikováno v: Molecular Therapy. 15:618-627

Hematopoietic cell transplantation can impact lysosomal storage disorders (LSDs) and will be enhanced by gene therapy. Transduced cells in LSDs often secrete the therapeutic hydrolase, which can be used by bystander cells. However, toxicity associate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf6145f8cb84be2d71f3769f98fc9c8
https://doi.org/10.1038/sj.mt.6300075