Výsledky vyhledávání - "Armando G. Peoppl"

CD123 (IL-3 Receptor α Chain) Neutralization by a Monoclonal Antibody Selectively Eliminates Human Acute Myeloid Leukemic Stem Cells

Autor: Hayley S. Ramshaw, Sam Busfield, Liqing Jin, Richard B. Lock, John E. Dick, Gino Vairo, David Gearing, Mark A. Guthridge, Erwin M. Lee, Lucy Wilkinson, Andrew W. Boyd, Angel F. Lopez, Armando G. Peoppl

Publikováno v: Blood. 110:161-161

Development of effective therapies against acute myeloid leukemia (AML) will likely require elimination of the leukemic stem cell (LSC), which maintains the AML hierarchy. Based on high expression of the IL-3 receptor α chain (CD123) on AML-LSC, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c415d0392b77b505c374714ce56258d2
https://doi.org/10.1182/blood.v110.11.161.161

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Monoclonal Antibody-Mediated Targeting of CD123, IL-3 Receptor α Chain, Eliminates Human Acute Myeloid Leukemic Stem Cells

Autor: Lucy Wilkinson, Andrew W. Boyd, Gino Vairo, Armando G. Peoppl, Erwin M. Lee, Samantha J. Busfield, Hayley S. Ramshaw, David Gearing, Angel F. Lopez, Daniel Thomas, Liqing Jin, Richard B. Lock, John E. Dick, Mark A. Guthridge, Emma F Barry

Publikováno v: Cell Stem Cell. (1):31-42

Leukemia stem cells (LSCs) initiate and sustain the acute myeloid leukemia (AML) clonal hierarchy and possess biological properties rendering them resistant to conventional chemotherapy. The poor survival of AML patients raises expectations that LSC-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::947fe7ed223c6ee863b3b0f91c3d6d78

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