Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Armanda E. Santos"'
Autor:
Tânia Fernandes, Rosa Resende, Diana F. Silva, Ana P. Marques, Armanda E. Santos, Sandra M. Cardoso, M. Rosário Domingues, Paula I. Moreira, Cláudia F. Pereira
Publikováno v:
Biomedicines, Vol 9, Iss 8, p 881 (2021)
Alzheimer’s disease (AD) is characterized by the accumulation of extracellular plaques composed by amyloid-β (Aβ) and intracellular neurofibrillary tangles of hyperphosphorylated tau. AD-related neurodegenerative mechanisms involve early changes
Externí odkaz:
https://doaj.org/article/3c2f824e50674e3c8260bf601158a508
Autor:
Marta M. Vieira, Jeannette Schmidt, Joana S. Ferreira, Kevin She, Shinichiro Oku, Miranda Mele, Armanda E. Santos, Carlos B. Duarte, Ann Marie Craig, Ana Luísa Carvalho
Publikováno v:
Neurobiology of Disease, Vol 89, Iss , Pp 223-234 (2016)
Global cerebral ischemia induces selective degeneration of specific subsets of neurons throughout the brain, particularly in the hippocampus and cortex. One of the major hallmarks of cerebral ischemia is excitotoxicity, characterized by overactivatio
Externí odkaz:
https://doaj.org/article/7d7460193e4a4df9af34319a6e70f012
Autor:
Ana Silva, Marta Pereira, Mylène A. Carrascal, Gonçalo Brites, Bruno Neves, Patrícia Moreira, Rosa Resende, Maria Manuel Silva, Armanda E. Santos, Cláudia Pereira, Maria Teresa Cruz
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 20, p 7791 (2020)
Experimental evidence highlights nuclear factor (erythroid-derived 2)-like 2 (Nrf2) as a molecular target in Alzheimer’s disease (AD). The well-known effect of electrophilic cysteine-reactive skin allergens on Nrf2-activation led to the hypothesis
Externí odkaz:
https://doaj.org/article/4c53784a711f452d8bc10b2e1bd553dc
Autor:
Judite R. M. Coimbra, Salete J. Baptista, Teresa C. P. Dinis, Maria M. C. Silva, Paula I. Moreira, Armanda E. Santos, Jorge A. R. Salvador
Publikováno v:
Biomolecules, Vol 10, Iss 4, p 535 (2020)
The treatment options for a patient diagnosed with Alzheimer’s disease (AD) are currently limited. The cerebral accumulation of amyloid-β (Aβ) is a critical molecular event in the pathogenesis of AD. When the amyloidogenic β-secretase (BACE1) is
Externí odkaz:
https://doaj.org/article/b956f6a9c4874660b56c184c163a53d9
Autor:
Judite R. M. Coimbra, Daniela F. F. Marques, Salete J. Baptista, Cláudia M. F. Pereira, Paula I. Moreira, Teresa C. P. Dinis, Armanda E. Santos, Jorge A. R. Salvador
Publikováno v:
Frontiers in Chemistry, Vol 6 (2018)
Alzheimer's disease (AD) is a severe neurodegenerative disorder and the most common type of dementia in the elderly. The clinical symptoms of AD include a progressive loss of memory and impairment of cognitive functions interfering with daily life ac
Externí odkaz:
https://doaj.org/article/781cd9b1ae714b2086ee1e78dee73829
Autor:
Andrea C. Lobo, João R. Gomes, Tatiana Catarino, Miranda Mele, Pedro Fernandez, Ana R. Inácio, Ben A. Bahr, Armanda E. Santos, Tadeusz Wieloch, Ana Luísa Carvalho, Carlos B. Duarte
Publikováno v:
Neurobiology of Disease, Vol 44, Iss 3, Pp 292-303 (2011)
Glutamate is loaded into synaptic vesicles by vesicular glutamate transporters (VGLUTs), and alterations in the transporters expression directly regulate neurotransmitter release. We investigated changes in VGLUT1 and VGLUT2 protein levels after isch
Externí odkaz:
https://doaj.org/article/4dada7c13056462ba5e4212bced3e21c
Publikováno v:
Drug Discovery Today. :103644
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f2a47b76392aec1439d2f6edf34782e
https://doi.org/10.1016/j.drudis.2023.103644
https://doi.org/10.1016/j.drudis.2023.103644
Autor:
Rosa Resende, M. Manuel Cruz Silva, Bruno Miguel Neves, Armanda E. Santos, Ana Silva, Patrícia Moreira, Marta I Pereira, Mylène A. Carrascal, Gonçalo Brites, Maria Teresa Cruz, Cláudia Pereira
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 7791, p 7791 (2020)
Volume 21
Issue 20
International Journal of Molecular Sciences, Vol 21, Iss 7791, p 7791 (2020)
Volume 21
Issue 20
Experimental evidence highlights nuclear factor (erythroid-derived 2)-like 2 (Nrf2) as a molecular target in Alzheimer&rsquo
s disease (AD). The well-known effect of electrophilic cysteine-reactive skin allergens on Nrf2-activation led to the hy
s disease (AD). The well-known effect of electrophilic cysteine-reactive skin allergens on Nrf2-activation led to the hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e85dcc7cf1365017add19dfc8e077a0
http://europepmc.org/articles/PMC7594024
http://europepmc.org/articles/PMC7594024
Autor:
Armanda E. Santos, Paula I. Moreira, M. Manuel Cruz Silva, Salete J. Baptista, Jorge A. R. Salvador, Judite R M Coimbra, Teresa C.P. Dinis
Publikováno v:
Biomolecules
Volume 10
Issue 4
Biomolecules, Vol 10, Iss 535, p 535 (2020)
Volume 10
Issue 4
Biomolecules, Vol 10, Iss 535, p 535 (2020)
The treatment options for a patient diagnosed with Alzheimer&rsquo
s disease (AD) are currently limited. The cerebral accumulation of amyloid-&beta
(A&beta
) is a critical molecular event in the pathogenesis of AD. When the amyloidogen
s disease (AD) are currently limited. The cerebral accumulation of amyloid-&beta
(A&beta
) is a critical molecular event in the pathogenesis of AD. When the amyloidogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a5c07902bd074469297ce4c967fb906
Autor:
Paula I. Moreira, Pedro J. M. Sobral, Armanda E. Santos, Judite R M Coimbra, Jorge Ar Salvador
Publikováno v:
Future medicinal chemistry. 11(24)
A diverse range of N-terminally truncated and modified forms of amyloid-β (Aβ) oligomers have been discovered in Alzheimer’s disease brains, including the pyroglutamate-Aβ (AβpE3). AβpE3 species are shown to be more neurotoxic when compared wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b726d321bd4da23e1ce4139228e697a1
https://pubmed.ncbi.nlm.nih.gov/31838899
https://pubmed.ncbi.nlm.nih.gov/31838899