Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Arman Lira"'
Publikováno v:
Journal of Biological Chemistry. 286:28783-28793
Although there is growing evidence for a role of the innate immune response in Parkinson's disease, the nature of any humoral response in dopaminergic degeneration is uncertain. Here we report on a protracted N-methyl-4-phenyl-1,2,3,6-tetrahydropyrid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0251eeaa218b8b516376ec8071ab67e4
https://doi.org/10.1074/jbc.m111.244830
https://doi.org/10.1074/jbc.m111.244830
Autor:
Patrice D. Smith, Sylvie Faucher, Shawn Hayley, Ruth S. Slack, Hymie Anisman, Matthew P. Mount, Arman Lira, David S. Park, David Grimes
Publikováno v:
The Journal of Neuroscience. 27:3328-3337
Growing evidence implicates microglia in the loss of dopaminergic neurons in Parkinson's disease (PD). However, factors mediating microglial activation in PD are poorly understood. Proinflammatory cytokines, such as interferon-γ (IFN-γ), orchestrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f618098f883555252e72df6d7ad775c5
https://doi.org/10.1523/jneurosci.5321-06.2007
https://doi.org/10.1523/jneurosci.5321-06.2007
Autor:
Ruth S. Slack, Mireille Daigle, Maxime W.C. Rousseaux, Emdadul Haque, Steve M. Callaghan, Yi Zhang, Matthew P. Mount, Inez Vincent, Arman Lira, David S. Park, Dianbo Qu, Paul R. Albert, Hossein Aleyasin, John Woulfe, Mohammad Parsanejad, Juliet Rashidian
Publikováno v:
Neuron. (1):37-52
SummaryWe reported previously that calpain-mediated Cdk5 activation is critical for mitochondrial toxin-induced dopaminergic death. Here, we report a target that mediates this loss. Prx2, an antioxidant enzyme, binds Cdk5/p35. Prx2 is phosphorylated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd971d8254edc4fcb7439ebfcd4f3740