Výsledky vyhledávání - "Armaghan Emami"

Toxicology Evaluation of Drugs Administered via Uncommon Routes: Intranasal, Intraocular, Intrathecal/Intraspinal, and Intra-Articular

Autor: Armaghan Emami, Jeff Tepper, Jay H Chang, Alvaro F Cisternas, R. Daniel Mellon, Tony L. Yaksh, Alison M Bendele, Brian Short, Thulasi Ramani

Publikováno v: International journal of toxicology, vol 37, iss 1

As the need for nasal, ocular, spinal, and articular therapeutic compounds increases, toxicology assessments of drugs administered via these routes play an important role in human safety. This symposium outlined the local and systemic evaluation to s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5242a93f06634924701839e8c257eb1
https://doi.org/10.1177/1091581817741840

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Effects of Epigallocatechin Gallate, L-Ascorbic Acid, α-Tocopherol, and Dihydrolipoic Acid on the Formation of Deoxyguanosine Adducts Derived From Lipid Peroxidation

Autor: Raghu G. Nath, Fung-Lung Chung, Armaghan Emami, Mona Y. Wu

Publikováno v: Nutrition and Cancer. 62:622-629

Oxidation of polyunsaturated fatty acids (PUFAs) releases alpha,beta-unsaturated aldehydes that modify deoxyguanosine (dG) to form cyclic 1,N(2)-propanodeoxyguanosine adducts. One of the major adducts detected in vivo is acrolein (Acr)-derived 1,N(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985249e4eaf16bd788c46334e89fd523
https://doi.org/10.1080/01635580903532424

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Acrolein-derived DNA adduct formation in human colon cancer cells: its role in apoptosis induction by docosahexaenoic acid

Autor: Jessica L. Keffer, Radoslav Goldman, Armaghan Emami, Jishen Pan, Fung-Lung Chung, Renny S. Lan, Xiaoyue Ma

The apoptotic effects of docosahexaenoic acid (DHA) and other omega-3 polyunsaturated fatty acids (PUFAs) have been documented in cell and animal studies. The molecular mechanism by which DHA induces apoptosis is unclear. Although there is no direct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4f13c9bc4c0c078642e28dce559ad35
https://europepmc.org/articles/PMC2683896/

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Detection of the acrolein-derived cyclic DNA adduct by a quantitative 32P-postlabeling/solid-phase extraction/HPLC method: blocking its artifact formation with glutathione

Autor: Amrita K. Cheema, Armaghan Emami, Raghu G. Nath, Marcin Dyba, Fung-Lung Chung, Jishen Pan

Publikováno v: Analytical biochemistry. 374(1)

Acrolein (Acr), a hazardous air pollutant, reacts readily with deoxyguanosine (dG) in DNA to produce cyclic 1, N 2 -propanodeoxyguanosine adducts (Acr-dG). Studies demonstrate that these adducts are detected in vivo and may play a role in mutagenesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c07ecc83f34a307b9b13f5ecc3864d81
https://pubmed.ncbi.nlm.nih.gov/18036548

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P-glycoprotein enhances TRAIL-triggered apoptosis in multidrug resistant cancer cells by interacting with the death receptor DR5

Autor: Soo Jung Park, Ching Huang Wu, Ahmad R. Safa, Armaghan Emami, Mi Ran Choi, Farhad Najafi

Publikováno v: Biochemical pharmacology. 72(3)

The death-inducing cytokine TRAIL is a promising agent for anticancer therapy since it preferentially kills cancer versus normal cells; however, some cancer cells are TRAIL-resistant. We initially explored whether overexpression of the MDR1 gene prod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42f84dad2531d74e4cda0a7807eec0b0
https://pubmed.ncbi.nlm.nih.gov/16753135

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Taxol induces caspase-10-dependent apoptosis

Autor: John Gordon, Xiaoling Zhong, Ahmad R. Safa, Ching-Haung Wu, Soo-Jung Park, Armaghan Emami

Publikováno v: The Journal of biological chemistry. 279(49)

Taxol (paclitaxel) is known to inhibit cell growth and trigger significant apoptosis in various cancer cells. Although taxol induces apoptosis of cancer cells, its exact mechanism of action is not yet known. In this study we investigated death recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ec9335be6d12fdd89ee1663fb7e01f
https://pubmed.ncbi.nlm.nih.gov/15452117

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