Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Arlo Parker"'
Publikováno v:
Solid State Nuclear Magnetic Resonance. 79:1-5
The measurement of the dipolar interaction between two spins provides the distance between nuclei. A better structural picture emerges when the distance is combined with the orientation of the internuclear vector in the principal axis system of the c
Autor:
Megan M. Maurer, Samaneh Ghassabi Kondalaji, Arlo Parker, Stephen J. Valentine, Justin Legleiter, James R. Arndt
Publikováno v:
Biochemistry. 54:4285-4296
Early-stage oligomer formation of the huntingtin protein may be driven by self-association of the seventeen-residue amphipathic α-helix at the protein’s N-terminus (Nt17). Oligomeric structures have been implicated in neuronal toxicity and may rep
Autor:
James R. Arndt, Stephen J. Valentine, Samaneh Ghassabi Kondalaji, Arlo Parker, Justin Legleiter, Megan M. Maurer, Olivia Sarver
Publikováno v:
Biophysical Journal. (2):385a
Huntingtin aggregate morphology and kinetics are modulated by the presence of two flanking sequences: a seventeen-residue α-helix (Nt17) which lies N-terminal to the amyloidogenic polyglutamine region; and a polyproline PPII helix that is C-terminal