Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Arlene Stark"'
Summary The behavioural response following infusion of a novel, stable substance P (SP) analogue, DiMe-C7, into the ventral tegmental area (VTA) of rats was characterized and contrasted with the response to an equal dose of the parent compound SP. Di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c0f745db7088f89f0059e3580713b8
https://doi.org/10.1016/0006-8993(82)90777-6
https://doi.org/10.1016/0006-8993(82)90777-6
Autor:
Thaddeus F. Molski, Kevin D. Burris, Tanaz Mistry Kannan, Kelly A. Allers, Shaun Jordan, Tetsuro Kikuchi, Frank D. Yocca, Arlene Stark, Trevor Sharp, Robert L. Bertekap, Ruoyan Chen
BACKGROUND: Aripiprazole (7-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy}-3,4-dihydro-2(1H)-quinolinone) is a novel antipsychotic with a mechanism of action that differs from current typical and atypical antipsychotics. Aripiprazole interacts with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f31f87dc2f0b84e111aac6e450c3378d
https://doi.org/10.1007/s00213-006-0621-y
https://doi.org/10.1007/s00213-006-0621-y
Autor:
Arlene Stark, Rebecca Taub, Harvey Wong, Suresh Yeola, Randy C. Dockens, James E. Grace, Frank D. Yocca, Robert Zaczek, Lori Pajor, Yu-Wen Li
Publikováno v:
Drug Metabolism and Disposition. 35:1387-1392
The pharmacokinetics and in vivo potency of 6-hydroxybuspirone (6-OH-buspirone), a major metabolite of buspirone, were investigated. The plasma clearance (47.3 +/- 3.5 ml/min/kg), volume of distribution (2.6 +/- 0.3 l/kg), and half-life (1.2 +/- 0.2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b1a8c9f31d113bd51a9aa9853b748a9
https://doi.org/10.1124/dmd.107.015768
https://doi.org/10.1124/dmd.107.015768
Publikováno v:
The International journal of neuroscience. 118(1)
This study compared the D(2) partial agonists, aripiprazole, (R(+)-terguride; S(-)-3-(3-hydroxyphenyl)-N-n-propylpiperidine [S(-)-3-PPP]; 7-[3-[4-(2,3-dimethylphenyl)piperazinyl]propoxy]-2(1H)-quinolinone [OPC-4392]) and D(2) antagonists (haloperidol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026ddee1a38462b9fcf595cad20c02a4
https://pubmed.ncbi.nlm.nih.gov/18041605
https://pubmed.ncbi.nlm.nih.gov/18041605
Autor:
Arlene Stark, Hisashi Kitagawa, Robert A. Forbes, Tetsuro Kikuchi, Robert D. McQuade, Yoshihiro Tadori
Publikováno v:
European journal of pharmacology. 574(2-3)
Aripiprazole is the first dopamine D 2 receptor partial agonist approved for use in schizophrenia and bipolar disorder. Other partial agonists have failed in various stages of development, either for reasons of poor tolerability or lack of efficacy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d65303ab012533ed316eedd5b96d5f6
https://pubmed.ncbi.nlm.nih.gov/17692841
https://pubmed.ncbi.nlm.nih.gov/17692841
Autor:
Arlene Stark, Takashi Miwa, Toyoki Mori, Yoshihiro Tadori, Kevin D. Burris, Katsura Tottori, Tetsuro Kikuchi
Publikováno v:
European journal of pharmacology. 515(1-3)
Aripiprazole is the first clinically approved atypical antipsychotic agent having dopamine D2 receptor partial agonist activities. To evaluate aripiprazole's agonist and antagonist properties, we established a Chinese hamster ovary cell line expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2009f64471a106aede74ea652b8af03
https://pubmed.ncbi.nlm.nih.gov/15894311
https://pubmed.ncbi.nlm.nih.gov/15894311
Autor:
Lawrence G. Iben, Joseph P Yevich, Qi Gao, Michael F. Dee, Arlene Stark, Ronald J. Mattson, John R. Torrente, Kenneth M. Boy
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(17)
Conformationally constrained aryl cyclohexanes and cyclohexenes based on aryl cyclohexanols 1 were prepared. Locking the aryl ring in plane with the cyclohexane moiety provided potent SSRIs 3. Conversely, fixing the aryl ring perpendicular to the cyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7d615be4af78eb7acc7003345aec80
https://pubmed.ncbi.nlm.nih.gov/15357973
https://pubmed.ncbi.nlm.nih.gov/15357973
Autor:
Suresh Yeola, Yufen Zhao, Aiming Gao, Ronald J. Mattson, Michael A. Poss, Jane Palmer, Jeffrey A. Deskus, John D. Catt, Ashok V. Purandare, Dalton King, Arlene Stark, John R. Torrente, Graham Johnson, Michael F. Dee, David R. Tortolani, Jonathan L. Ditta, Derek J. Denhart, Hua Yang, James R. Epperson
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(16)
The present studies have identified a series of aminotriazines as novel 5-HT(7) receptor antagonists. Compounds 10 and 17 have high affinity for the 5-HT(7) receptor and do not bind to either the 5-HT(2C) or 5-HT(6) receptors. These compounds produce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea63093d8cad6c62016c160f857f8fc7
https://pubmed.ncbi.nlm.nih.gov/15261279
https://pubmed.ncbi.nlm.nih.gov/15261279
Autor:
Katsura Tottori, Tetsuro Kikuchi, Tsuyoshi Hirose, Hiroshi Okazaki, Arlene Stark, Yasuhiko Inoue, Hisashi Kitagawa
Publikováno v:
International Clinical Psychopharmacology. 20:A13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::819bdd811c597018e97f9382cff158fc
https://doi.org/10.1097/00004850-200505000-00050
https://doi.org/10.1097/00004850-200505000-00050
Publikováno v:
Neuroscience letters. 39(3)
Continuous amphetamine administration has proven to be a useful pharmacological tool. The two systems popularly used for the continuous administration of amphetamine differ in their release characteristics; output of drug from passive diffusion silic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fe8a4fd4687e848cf1c5c08ceb2eb5d
http://ora.ox.ac.uk/objects/uuid:d21434e2-1ca0-480c-a593-851e7e842536
http://ora.ox.ac.uk/objects/uuid:d21434e2-1ca0-480c-a593-851e7e842536