Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Arlene S Bridges"'
Autor:
John K Thuita, Kristina K Wolf, Grace A Murilla, Arlene S Bridges, David W Boykin, James N Mutuku, Qiang Liu, Susan K Jones, Charles O Gem, Shelley Ching, Richard R Tidwell, Michael Z Wang, Mary F Paine, Reto Brun
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 2, p e0003409 (2015)
Human African trypanosomiasis (HAT, sleeping sickness) ranks among the most neglected tropical diseases based on limited availability of drugs that are safe and efficacious, particularly against the second stage (central nervous system [CNS]) of infe
Externí odkaz:
https://doaj.org/article/aad4fdcad9934c25a153ed2b89ab73e9
Autor:
John K Thuita, Kristina K Wolf, Grace A Murilla, Qiang Liu, James N Mutuku, Yao Chen, Arlene S Bridges, Raymond E Mdachi, Mohamed A Ismail, Shelley Ching, David W Boykin, James Edwin Hall, Richard R Tidwell, Mary F Paine, Reto Brun, Michael Zhuo Wang
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 6, p e2230 (2013)
There are no oral drugs for human African trypanosomiasis (HAT, sleeping sickness). A successful oral drug would have the potential to reduce or eliminate the need for patient hospitalization, thus reducing healthcare costs of HAT. The development of
Externí odkaz:
https://doaj.org/article/3329b3b038db4c1fbbbafc2be436adde
Prostatic acid phosphatase is required for the antinociceptive effects of thiamine and benfotiamine.
Autor:
Julie K Hurt, Jennifer L Coleman, Brendan J Fitzpatrick, Bonnie Taylor-Blake, Arlene S Bridges, Pirkko Vihko, Mark J Zylka
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e48562 (2012)
Thiamine (Vitamin B1) is an essential vitamin that must be obtained from the diet for proper neurological function. At higher doses, thiamine and benfotiamine (S-benzoylthiamine O-monophosphate, BT)-a phosphorylated derivative of thiamine-have antino
Externí odkaz:
https://doaj.org/article/94a81905acde459b9e7dc4a62c01d6f9
Autor:
Kim L. R. Brouwer, Nathan D. Pfeifer, Brian C. Ferslew, Rhiannon N. Hardwick, Arlene S. Bridges
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 347:737-745
Basolateral efflux clearance (CLBL) contributes significantly to rosuvastatin (RSV) elimination in sandwich-cultured hepatocytes (SCH). The contribution of CLBL to RSV hepatic elimination was determined in single-pass isolated perfused livers (IPLs)
Autor:
Mary F. Paine, Dhiren R. Thakker, David W. Boykin, Richard R. Tidwell, Mohamed A. Ismail, Arlene S. Bridges, Claudia N. Generaux, Garrett R. Ainslie
Publikováno v:
Drug Metabolism and Disposition. 41:518-528
DB868 [2,5-bis [5-(N-methoxyamidino)-2-pyridyl] furan], a prodrug of the diamidine DB829 [2,5-bis(5-amidino-2-pyridyl) furan], has demonstrated efficacy in murine models of human African trypanosomiasis. A cross-species evaluation of prodrug bioconve
Autor:
Joyce A. Goldstein, Arlene S. Bridges, Melanie S. Joy, Yichun Hu, Mary Anne Dooley, Joyce Blaisdell, Kim L. R. Brouwer, Ronald J. Falk, Mary La, Jinzhao Wang, Reginald F. Frye, Susan L. Hogan
Publikováno v:
British Journal of Clinical Pharmacology. 74:445-455
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • The pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide in cancer patients have been well described. The current study was conducted to document the pharmacokinetics of cyclophosphamide and
Autor:
Arlene S. Bridges, J. Heyward Hull, Paul B. Watkins, E. Claire Dees, Daniel L. Hertz, Christine M. Walko, Jill M Herendeen, Kristan D. Rollins
Publikováno v:
British Journal of Clinical Pharmacology. 74:197-200
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Paclitaxel and rosiglitazone are primarily metabolized by CYP2C8 and their in vitro metabolism by human liver microsomes is correlated. Probe assays that quantify the in vivo activity of CYP enzymes which
Autor:
Jayalakshmi Miriyala, Hyeong Min Lee, Xin Chen, J. Walter Dutton, Bryan L. Roth, Noah Sciaky, Hsien-Sung Huang, John A. Allen, Angela M. Mabb, Bonnie Taylor-Blake, Mark J. Zylka, Jian Jin, Ian F. G. King, Arlene S. Bridges, Benjamin D. Philpot
Publikováno v:
Nature
Cancer drugs that can potentially treat Angelman syndrome are identified. Genomic imprinting disorders arise owing to a loss of function of non-imprinted alleles expressed from one parent. In Angelman syndrome, a neurodevelopmental disorder caused by
Autor:
Joseph L. Kelley, Thomas C. Krivak, Austin J. Combest, Angela Y. C. Yu, Robert P. Edwards, Julie A. DeLoia, Arlene S. Bridges, Christine M. Walko, Beth A. Zamboni, William C. Zamboni
Publikováno v:
Cancer Chemotherapy and Pharmacology. 68:1255-1262
The objectives of this study were to determine whether the midazolam clearance predicted docetaxel pharmacokinetics, CA-125 change, and response and to assess the impact of cytochrome P450 (CYP) 3A5 and ATP-binding cassette, subfamily B, member 1 (AB
Autor:
Michel Weïwer, Arlene S. Bridges, Paul L. DeAngelis, Jian Liu, Renpeng Liu, Miao Chen, Qisheng Zhang, Xianxuan Zhou, Robert J. Linhardt, Yongmei Xu
Publikováno v:
Journal of Biological Chemistry. 285:34240-34249
Heparan sulfate is a sulfated glycan that exhibits essential physiological functions. Interrogation of the specificity of heparan sulfate-mediated activities demands a library of structurally defined oligosaccharides. Chemical synthesis of large hepa