Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Arlene Rockwell"'
Autor:
Douglas Guy Batt, William F. DeGrado, Arlene Rockwell, Prabhakar K. Jadhav, Joseph J. Petraitis, Shaker A. Mousa, Maria Rafalski, William J. Pitts
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:937-942
Isoxazoline containing RGD mimetics were rapidly synthesized on a solid phase to optimize linkers, regioisomers of isoxazoline scaffolds, and exosite binding groups to yield lead alphavbeta3 antagonists.
Autor:
Kevin R. Oldenburg, Arlene Rockwell, Andrew P. Combs, Ji-Hu Zhang, Karl F. Blom, Tongming Chen
Publikováno v:
Rapid Communications in Mass Spectrometry. 12:1192-1198
A mass spectrometric strategy for the direct determination of the structures of compounds on active beads selected from combinatorial mixtures by ultrahigh throughput screening is presented. Complementary mass spectrometric data (exact mass and MS/MS
Autor:
John Roderick, Chu-Biao Xue, Sharon A. Jackson, Richard E. Olson, Shaker A. Mousa, William F. DeGrado, Maria Rafalski, Arlene Rockwell
Publikováno v:
Bioorganic & Medicinal Chemistry. 5:693-705
In an effort to discover novel nonpeptide glycoprotein IIb/IIIa (GPIIb/IIIa, alpha IIb/beta 3) inhibitors, we investigated RGD mimetics featuring a 3-substituted benzoic acid as the core, benzamidine as the basic moiety, and a series of beta- and alp
Publikováno v:
Pharmaceutical Research. 13:481-484
Publikováno v:
Protein Science. 3:2419-2427
The introduction of disulfide crosslinks is a generally useful method by which to identify regions of a protein that are close together in space. Here we describe the use of disulfide crosslinks to investigate the structure and flexibility of a famil
Autor:
Sharon M. Jackson, Anju Parthasarathy, J. Krywko, A. Higley, Arlene Rockwell, William F. DeGrado, A. Dwivedi, Gerald A. H. Wells, J. Markwalder
Publikováno v:
Journal of the American Chemical Society. 116:3220-3230
Autor:
Christopher D. Richardson, Arlene Rockwell, James J. Cheetham, Raquel F. Epand, Philip L. Yeagle, Richard M. Epand, William F. DeGrado
Publikováno v:
Biopolymers. 32:309-314
In order to be infectious, viruses must possess a mechanism allowing their nucleic acid to pass through the plasma membrane of the target cells. Two such mechanisms have been described for en- veloped viruses, both requiring membrane fusion. One path
Autor:
Arlene Rockwell, Mark Melden, Robert A. Copeland, and Carl P. Decicco, William F. DeGrado, Karl D. Hardman
Publikováno v:
Journal of the American Chemical Society. 118:10337-10338
Publikováno v:
Pharmaceutical Research; Mar1996, Vol. 13 Issue 3, p481-484, 4p