Výsledky vyhledávání - "Arlene L. Young"

Identification of benzofuran central cores for the inhibition of leukotriene A4 hydrolase

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 23:811-815

Leukotrienes (LT's) are known to play a physiological role in inflammatory immune response. Leukotriene A(4) hydrolase (LTA(4)H) is a cystolic enzyme that stereospecifically catalyzes the transformation of LTA(4) to LTB(4). LTB(4) is a known pro-infl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7e1edc94e27be30035be373870b432
https://doi.org/10.1016/j.bmcl.2012.11.074

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Azabenzthiazole inhibitors of leukotriene A4 hydrolase

Autor: Jonathan M. Blevitt, Arlene L. Young, Xiaohua Xue, Genesis M. Bacani, Aimee Rose de Leon, Alejandro Santillan, Adrienne M. Landry-Bayle, Aaron M. Kearney, John J. M. Wiener, Laurent Gomez, Anne M. Fourie, Jason P. Riley, Krystal Herman, Christa C. Chrovian, Cheryl A. Grice, Shelby Crawford, Jay Nelson, Alice Lee-Dutra, Virginia M. Tanis

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 22:7504-7511

Previously, benzthiazole containing LTA4H inhibitors were discovered that were potent (1–3), but were associated with the potential for a hERG liability. Utilizing medicinal chemistry first principles (e.g., introducing rigidity, lowering c Log D)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35a5468ed5af090759b0400d5ef00168
https://doi.org/10.1016/j.bmcl.2012.10.036

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Structural Integrity of Histone H2B in Vivo Requires the Activity of Protein l-IsoaspartateO-Methyltransferase, a Putative Protein Repair Enzyme

Autor: Hester A. Doyle, Mark J. Mamula, Wayne G. Carter, Arlene L. Young, Dana W. Aswad

Publikováno v: Journal of Biological Chemistry. 276:37161-37165

Protein L-isoaspartate O-methyltransferase (PIMT) is postulated to repair beta-aspartyl linkages (isoaspartyl (isoAsp)) that accumulate at certain Asp-Xaa and Asn-Xaa sites in association with protein aging and deamidation. To identify major targets

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b3991715dd8e013fa23b1f902a05b9
https://doi.org/10.1074/jbc.m106682200

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Azabenzthiazole inhibitors of leukotriene A₄ hydrolase

Autor: Virginia M, Tanis, Genesis M, Bacani, Jonathan M, Blevitt, Christa C, Chrovian, Shelby, Crawford, Aimee, De Leon, Anne M, Fourie, Laurent, Gomez, Cheryl A, Grice, Krystal, Herman, Aaron M, Kearney, Adrienne M, Landry-Bayle, Alice, Lee-Dutra, Jay, Nelson, Jason P, Riley, Alejandro, Santillán, John J M, Wiener, Xiaohua, Xue, Arlene L, Young

Publikováno v: Bioorganicmedicinal chemistry letters. 22(24)

Previously, benzthiazole containing LTA(4)H inhibitors were discovered that were potent (1-3), but were associated with the potential for a hERG liability. Utilizing medicinal chemistry first principles (e.g., introducing rigidity, lowering cLogD) a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::acc689db16d005c56ec392d77c4f18cc
https://pubmed.ncbi.nlm.nih.gov/23127888

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Effect of activin A on globin gene expression in purified human erythroid progenitors

Autor: Joan Vaughan, Alice L. Yu, John Yu, Li-en Shao, Normand L. Frigon, Arlene L. Young, Lawrence S. Mathews, Wylie Vale

Publikováno v: Blood. 79:773-781

The regulatory control of human erythropoiesis through a purified protein, activin A, was examined. Previous studies using mixed populations of bone marrow cells suggested that activin A has an indirect effect on cellular proliferation and DNA synthe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a23845906a8e719b44502b98a59558f
https://doi.org/10.1182/blood.v79.3.773.773

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Regulation of globin gene expression in human K562 cells by recombinant activin A

Autor: Arlene L. Young, Normand L. Frigon, Lina Maderazo, John Yu, Li-en Shao

Publikováno v: Europe PubMed Central

Recent studies indicate that a purified protein, activin A, belongs to the transforming growth factor beta (TGF-beta) superfamily. Similar to TGF-beta, activin A can have different biologic activities, depending on the target tissues. We used recombi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a5677c074056e6aea31343d1319024
https://doi.org/10.1182/blood.v79.3.765.bloodjournal793765

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