Výsledky vyhledávání - "Arlene L. Higdon"

Changes in Prostate-Specific Antigen (PSA) Level Correlate with Growth Inhibition of Prostate Cancer Cells Treated in Vitro with a Novel Anticancer Drug, Irofulven

Autor: Arlene L. Higdon, Barbara A. Woynarowska, Perry Bushong, Stephen J. Waters, Ruben M. Muñoz

Publikováno v: Investigational New Drugs. 19:283-291

Irofulven (hydroxymethylacylfulvene, HMAF, MGI 114) is a novel agent with alkylating activity and a potent inducer of apoptosis. It is currently undergoing Phase II clinical trials for several tumor types, including hormone-refractory prostate cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a24718e83b227b454c30bdd8729b11
https://doi.org/10.1023/a:1010601524630

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Differential cytotoxicity and induction of apoptosis in tumor and normal cells by hydroxymethylacylfulvene (HMAF)

Autor: John R. MacDonald, Kari Roberts, Jan M. Woynarowski, Arlene L. Higdon, Barbara A. Woynarowska, Maryanne C. Herzig

Publikováno v: Biochemical pharmacology. 59(10)

This investigation compared the effects of hydroxymethylacylfulvene (HMAF), a novel antitumor drug with alkylating properties, in eight human tumor (prostate, colon, and leukemia) cell lines, and five human normal (prostate and renal proximal tubule

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3a3e153d6ceffcc35af0ab19171257
https://pubmed.ncbi.nlm.nih.gov/10736422

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