Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Arlene Hwang"'
Publikováno v:
The Journal of biological chemistry. 283(31)
Cells with functional DNA mismatch repair (MMR) stimulate G(2) cell cycle checkpoint arrest and apoptosis in response to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). MMR-deficient cells fail to detect MNNG-induced DNA damage, resulting in the surviva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f5198c6407f113d401e15c26fae341
https://pubmed.ncbi.nlm.nih.gov/18480060
https://pubmed.ncbi.nlm.nih.gov/18480060
Publikováno v:
Environmental and molecular mutagenesis. 44(4)
Deficiencies in DNA mismatch repair (MMR) have been found in both hereditary cancer (i.e., hereditary nonpolyposis colorectal cancer) and sporadic cancers of various tissues. In addition to its primary roles in the correction of DNA replication error
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cac2c94ac67eb83fde485ea090713cb
https://pubmed.ncbi.nlm.nih.gov/15468331
https://pubmed.ncbi.nlm.nih.gov/15468331
Autor:
Mark W. Wagner, David A. Boothman, Andrew J Bruening, W. David Sedwick, Mark Meyers, Martina L. Veigl, Arlene Hwang
Publikováno v:
Oncogene. 22(47)
The phenomenon of damage tolerance, whereby cells incur DNA lesions that are nonlethal, largely ignored, but highly mutagenic, appears to play a key role in carcinogenesis. Typically, these lesions are generated by alkylation of DNA or incorporation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a20a4e51f9083de0046f8a18ac93dddd
https://pubmed.ncbi.nlm.nih.gov/14576845
https://pubmed.ncbi.nlm.nih.gov/14576845
Autor:
Arlene Hwang, Ruth J. Muschel
Publikováno v:
Radiation Research. 150:S52
Exposure of mammalian cells to X rays results in prolongation of the cell cycle, including delays or arrests in G1, S and G2 phase. While G1-phase arrest occurs only in cells with wild-type p53 function, a G2-phase delay occurs in all cells regardles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac8d1cd466b826c4f84be3a33b956000
https://doi.org/10.2307/3579808
https://doi.org/10.2307/3579808