Zobrazeno 1 - 10
of 546
pro vyhledávání: '"Arlene H, Sharpe"'
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 9, Pp 1913-1921 (2023)
Abstract Our bodies are inhabited by trillions of microorganisms. The host immune system constantly interacts with the microbiota in barrier organs, including the intestines. Over decades, numerous studies have shown that our mucosal immune system is
Externí odkaz:
https://doaj.org/article/f3e2f9050e2e4626b69648f9146c0cb8
Autor:
J. Bryan Iorgulescu, Neil Ruthen, Ryuhjin Ahn, Eleni Panagioti, Prafulla C. Gokhale, Martha Neagu, Maria C. Speranza, Benjamin K. Eschle, Kara M. Soroko, Raziye Piranlioglu, Meenal Datta, Shanmugarajan Krishnan, Kathleen B. Yates, Gregory J. Baker, Rakesh K. Jain, Mario L. Suvà, Donna Neuberg, Forest M. White, E. Antonio Chiocca, Gordon J. Freeman, Arlene H. Sharpe, Catherine J. Wu, David A. Reardon
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundThe GL261 and CT2A syngeneic tumor lines are frequently used as immunocompetent orthotopic mouse models of human glioblastoma (huGBM) but demonstrate distinct differences in their responses to immunotherapy.MethodsTo decipher the cell-intri
Externí odkaz:
https://doaj.org/article/0d4ef411871943b490bc6d2c4f558fb2
Autor:
Benjamin P. Hurrell, Doumet Georges Helou, Emily Howard, Jacob D. Painter, Pedram Shafiei-Jahani, Arlene H. Sharpe, Omid Akbari
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Regulatory T (Treg) cells have been implicated in the induction of airway tolerance and amelioration of respiratory duct inflammation. Here the authors show, using PD-L2 deficient mice, that the immune suppression signal from PD-L2 is important for m
Externí odkaz:
https://doaj.org/article/dd4e965ac85f475c9f66e78325872bc5
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
GLPMs represent a population of fetal liver derived large peritoneal cavity Gata6+ macrophages, with the capacity to invade the tissues they surround. Here, in experimental colon cancer liver metastasis models, the authors show that GLPMs invade live
Externí odkaz:
https://doaj.org/article/a2fda9edf52d4f25bd04e59f9b9e384c
Autor:
Stinne R. Greisen, Tue W. Kragstrup, Jesper Skovhus Thomsen, Kim Hørslev-Pedersen, Merete Lund Hetland, Kristian Stengaard-Pedersen, Mikkel Østergaard, Lykke Ørnbjerg, Peter Junker, Arlene H. Sharpe, Gordon J. Freeman, Malene Hvid, Søren K. Moestrup, Ellen Margrethe Hauge, Bent Deleuran
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
ObjectiveThe programmed death-1 (PD-1) pathway is essential for maintaining self-tolerance and plays an important role in autoimmunity, including rheumatoid arthritis (RA). Here, we investigated how membrane-bound and soluble (s)PD-1 influence bone h
Externí odkaz:
https://doaj.org/article/721728c51a5f41c1a23c8cb5c93f011d
Autor:
RuthMabel Boytz, Scott Seitz, Emily Gaudiano, J. J. Patten, Patrick T. Keiser, John H. Connor, Arlene H. Sharpe, Robert A. Davey
Publikováno v:
Viruses, Vol 15, Iss 1, p 43 (2022)
Viral pathogens with the potential to cause widespread disruption to human health and society continue to emerge or re-emerge around the world. Research on such viruses often involves high biocontainment laboratories (BSL3 or BSL4), but the developme
Externí odkaz:
https://doaj.org/article/7a59686be2524014ba58bcddcfe3cb14
Autor:
Liankang Sun, Yuanguo Wang, Xianghu Wang, Amaia Navarro-Corcuera, Sumera Ilyas, Nidhi Jalan-Sakrikar, Can Gan, Xinyi Tu, Yu Shi, Kangsheng Tu, Qingguang Liu, Zhenkun Lou, Haidong Dong, Arlene H. Sharpe, Vijay H. Shah, Ningling Kang
Publikováno v:
Cell Reports, Vol 38, Iss 6, Pp 110349- (2022)
Summary: Intrahepatic cholangiocarcinoma (ICC) contains abundant myofibroblasts derived from hepatic stellate cells (HSCs) through an activation process mediated by TGF-β. To determine the role of programmed death-ligand 1 (PD-L1) in myofibroblastic
Externí odkaz:
https://doaj.org/article/c9ce8462951c41878250cb90b74ca0e3
Autor:
Thiago J. Borges, Naoka Murakami, Isadora T. Lape, Rodrigo B. Gassen, Kaifeng Liu, Songjie Cai, Joe Daccache, Kassem Safa, Tetsunosuke Shimizu, Shunsuke Ohori, Alison M. Paterson, Paolo Cravedi, Jamil Azzi, Peter T. Sage, Arlene H. Sharpe, Xian C. Li, Leonardo V. Riella
Publikováno v:
JCI Insight, Vol 6, Iss 24 (2021)
The programmed death 1/programmed death ligand 1 (PD-1/PD-L1) pathway is a potent inhibitory pathway involved in immune regulation and is a potential therapeutic target in transplantation. In this study, we show that overexpression of PD-1 on T cells
Externí odkaz:
https://doaj.org/article/e5c5cdd28c4848f786e0494cfcee2014
PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity
Autor:
Doumet Georges Helou, Pedram Shafiei-Jahani, Richard Lo, Emily Howard, Benjamin P. Hurrell, Lauriane Galle-Treger, Jacob D. Painter, Gavin Lewis, Pejman Soroosh, Arlene H. Sharpe, Omid Akbari
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
PD-1 is a checkpoint inhibitory immune receptor that restrains proliferation and effector functions of a variety of cells, including ILC2s. Here the authors present a human PD-1 agonist that limits ILC2-dependent allergic airway disease in humanized
Externí odkaz:
https://doaj.org/article/7aaaa31742d140ac9e011cac9002ea8f
Autor:
Theresa L Walunas, Lisa H Butterfield, William J Murphy, Elizabeth M Jaffee, Bart O Roep, Nicholas L Bayless, Jeffrey A Bluestone, Samantha Bucktrout, Christian A Koch, Arlene H Sharpe
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 9 (2021)
Externí odkaz:
https://doaj.org/article/2c74437288b04a82a1e4c572de4bdb74