Zobrazeno 1 - 10
of 331
pro vyhledávání: '"Arlene B Chapman"'
Autor:
Patrick N Cunningham, Zhiying Wang, Megan L Grove, Rhonda M Cooper-DeHoff, Amber L Beitelshees, Yan Gong, John G Gums, Julie A Johnson, Stephen T Turner, Eric Boerwinkle, Arlene B Chapman
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0221957 (2019)
BackgroundHypertension (HTN) disproportionately affects African Americans (AAs), who respond better to thiazide diuretics than other antihypertensives. Variants of the APOL1 gene found in AAs are associated with a higher rate of kidney disease and pl
Externí odkaz:
https://doaj.org/article/b7b90da9426a414aaf85d890cebafa81
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0113808 (2015)
BACKGROUND:Cytochrome P450 2D6 (CYP2D6) gene duplication and multiplication can result in ultrarapid drug metabolism and therapeutic failure or excessive response in patients. Long range polymerase chain reaction (PCR), restriction fragment length po
Externí odkaz:
https://doaj.org/article/91927940c2b44166acf8a0d258a2abb6
Autor:
Caitrin W McDonough, Nancy K Gillis, Abdullah Alsultan, Shin-Wen Chang, Marina Kawaguchi-Suzuki, Jason E Lang, Mohamed Hossam A Shahin, Thomas W Buford, Nihal M El Rouby, Ana C C Sá, Taimour Y Langaee, John G Gums, Arlene B Chapman, Rhonda M Cooper-DeHoff, Stephen T Turner, Yan Gong, Julie A Johnson
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76984 (2013)
We sought to identify novel pharmacogenomic markers for HDL-C response to atenolol in participants with mild to moderate hypertension. We genotyped 768 hypertensive participants from the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR)
Externí odkaz:
https://doaj.org/article/43b24bd0d8ac4ea89759ec6bfc82818f
Autor:
Andreas D Kistler, Andreas L Serra, Justyna Siwy, Diane Poster, Fabienne Krauer, Vicente E Torres, Michal Mrug, Jared J Grantham, Kyongtae T Bae, James E Bost, William Mullen, Rudolf P Wüthrich, Harald Mischak, Arlene B Chapman
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53016 (2013)
Treatment options for autosomal dominant polycystic kidney disease (ADPKD) will likely become available in the near future, hence reliable diagnostic and prognostic biomarkers for the disease are strongly needed. Here, we aimed to define urinary prot
Externí odkaz:
https://doaj.org/article/7f1ebb423b8d46c0a90c2566f7c90e43
Autor:
MyPhuong T Le, Maximilian T Lobmeyer, Marcus Campbell, Jing Cheng, Zhiying Wang, Stephen T Turner, Arlene B Chapman, Eric Boerwinkle, John G Gums, Yan Gong, Richard J Johnson, Julie A Johnson
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e52062 (2013)
In the past few decades, consumption of added sugars has increased dramatically. Studies have linked high sugar intake with increased risk for a number of diseases. Importantly, fructose, a component of sugar, has been linked with the development of
Externí odkaz:
https://doaj.org/article/64f7046fd4bc4744b94e6bd4e616b343
Autor:
William R Wikoff, Reginald F Frye, Hongjie Zhu, Yan Gong, Stephen Boyle, Erik Churchill, Rhonda M Cooper-Dehoff, Amber L Beitelshees, Arlene B Chapman, Oliver Fiehn, Julie A Johnson, Rima Kaddurah-Daouk, Pharmacometabolomics Research Network
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57639 (2013)
Antihypertensive drugs are among the most commonly prescribed drugs for chronic disease worldwide. The response to antihypertensive drugs varies substantially between individuals and important factors such as race that contribute to this heterogeneit
Externí odkaz:
https://doaj.org/article/d2b6bc8cefe145d49acf45c164a8158f
Autor:
Mai Mehanna, Caitrin W. McDonough, Steven M. Smith, Yan Gong, John G. Gums, Arlene B. Chapman, Julie A. Johnson, Rhonda M. Cooper‐DeHoff
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 5, Pp n/a-n/a (2024)
Abstract Hypertensive patients with a higher proportion of genetic West African ancestry (%GWAA) have better blood pressure (BP) response to thiazide diuretics (TDs) and worse response to β‐blockers (BBs) than those with lower %GWAA, associated wi
Externí odkaz:
https://doaj.org/article/5862478c7ec74a70ac4bbdf364a4f014
Autor:
Lakshmi Manasa S. Chekka, Marwa Tantawy, Taimour Langaee, Danxin Wang, Rolf Renne, Arlene B. Chapman, John G. Gums, Eric Boerwinkle, Rhonda M. Cooper‐DeHoff, Julie A. Johnson
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 4 (2024)
Background Thiazide diuretics are the second most frequently prescribed class of antihypertensives, but up to 50% of patients with hypertension have minimal antihypertensive response to thiazides. We explored circulating microRNAs (miRNAs) in search
Externí odkaz:
https://doaj.org/article/6ac4f0a85e9d4a2dbff85592725bbc0d
Autor:
Ronald D. Perrone, Dorothee Oberdhan, John Ouyang, Daniel G. Bichet, Klemens Budde, Arlene B. Chapman, Berenice Y. Gitomer, Shigeo Horie, Albert C.M. Ong, Vicente E. Torres, A. Neil Turner, Holly Krasa
Publikováno v:
Kidney International Reports, Vol 8, Iss 5, Pp 989-1001 (2023)
Introduction: The course of autosomal dominant polycystic kidney disease (ADPKD) varies greatly among affected individuals, necessitating natural history studies to characterize the determinants and effects of disease progression. Therefore, we condu
Externí odkaz:
https://doaj.org/article/6263893d07674a6789c237002dc53cb4
Autor:
Lakshmi Manasa S. Chekka, Rhonda M. Cooper‐DeHoff, John G. Gums, Arlene B. Chapman, Julie A. Johnson
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 12, Pp 2858-2867 (2022)
Abstract This study conducted a pairwise comparison of antihypertensive and metabolic effects of hydrochlorothiazide (HCTZ) and chlorthalidone (CTD) at 25 mg/day in the same individuals to address the clinical dilemma on preferred thiazide for hypert
Externí odkaz:
https://doaj.org/article/b0d8a85e313142fba79f5220b5367fe2