Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Arleen P. Loewy"'
Autor:
Kane Huang, Arwyn Schumacher, Jian Su Shao, Susan R. Rittling, David T. Denhardt, Chung Fang Lai, Radhika Vattikuti, Arleen P. Loewy, Jun Cai, Dwight A. Towler, Venkat Seshadri
Publikováno v:
Circulation Research. 98:1479-1489
Osteopontin (OPN) is a cytokine upregulated in diabetic vascular disease. To better understand its role in vascular remodeling, we assessed how OPN controls metalloproteinase (MMP) activation in aortic adventitial myofibroblasts (AMFs) and A7r5 vascu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba35512b88844bac3b53261500748dff
https://doi.org/10.1161/01.res.0000227550.00426.60
https://doi.org/10.1161/01.res.0000227550.00426.60
Publikováno v:
Journal of Biological Chemistry. 279:32913-32923
Msx2 promotes osteogenic lineage allocation from mesenchymal progenitors but inhibits terminal differentiation demarcated by osteocalcin (OC) gene expression. Msx2 inhibits OC expression by targeting the fibroblast growth factor responsive element (O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::264c5f7040efaffa602d18f2d0d7b9e5
https://doi.org/10.1074/jbc.m314098200
https://doi.org/10.1074/jbc.m314098200
Autor:
Dwight A. Towler, Miri Bidder, Elizabeth P. Newberry, Tammy Latifi, Glenda Ferguson, David M. Willis, Arleen P. Loewy
Publikováno v:
Biochemistry. 39:8917-8928
In MC3T3E1 calvarial osteoblasts, fibroblast growth factor receptor (FGFR) signaling elicits multiple transcriptional responses, including upregulation of the interstitial collagenase/matrix metalloproteinase 1 (MMP1) promoter. FGF responsiveness map
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2094d34e5f72b193b93575c412642f07
https://doi.org/10.1021/bi000343+
https://doi.org/10.1021/bi000343+
Publikováno v:
Annals of the New York Academy of Sciences. 1068
Vascular calcification increasingly afflicts our aging and dysmetabolic population, predisposing patients to cardiovascular mortality and lower extremity amputation. Active osteogenic processes are evident in most histoanatomic variants, including el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ade248c1eeadf968429285d457e85b0
https://pubmed.ncbi.nlm.nih.gov/16831933
https://pubmed.ncbi.nlm.nih.gov/16831933
Autor:
Jian Su Shao, Joyce M. Pingsterhaus, Arleen P. Loewy, Nichole Charlton-Kachigian, Su Li Cheng, Dwight A. Towler
Publikováno v:
The Journal of clinical investigation. 115(5)
In diabetic LDLR-/- mice, an ectopic BMP2-Msx2 gene regulatory program is upregulated in association with vascular calcification. We verified the procalcific actions of aortic Msx2 expression in vivo. CMV-Msx2 transgenic (CMV-Msx2Tg(+)) mice expresse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e170e233e4aa95c0746fb3bff832d649
https://pubmed.ncbi.nlm.nih.gov/15841209
https://pubmed.ncbi.nlm.nih.gov/15841209
Publikováno v:
The Journal of biological chemistry. 278(50)
Cardiovascular calcification is a common consequence of diabetes. High fat diets induce diabetes and arterial calcification in male low density lipoprotein receptor (LDLR) -/- mice; calcification occurs via Msx2 signaling that promotes the osteogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e432472f2aac8b36a983e2330b874e8
https://pubmed.ncbi.nlm.nih.gov/14504275
https://pubmed.ncbi.nlm.nih.gov/14504275
Autor:
Clay F. Semenkovich, Nichole Charlton-Kachigian, Dwight A. Towler, Arleen P. Loewy, Jian Su Shao, Miri Bidder
Publikováno v:
The Journal of biological chemistry. 277(46)
The expression of the matrix cytokine osteopontin (OPN) is up-regulated in aortic vascular smooth muscle cells (VSMCs) by diabetes. OPN expression in cultured VSMCs is reciprocally regulated by glucose and 2-deoxyglucose (2-DG; inhibitor of cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::281d83226d22e14499f3630e1d7a96e6
https://pubmed.ncbi.nlm.nih.gov/12200434
https://pubmed.ncbi.nlm.nih.gov/12200434
Autor:
Nichole Charlton-Kachigian, Dwight A. Towler, David M. Willis, Arleen P. Loewy, David M. Ornitz, Jian-Su Shao
Publikováno v:
The Journal of biological chemistry. 277(40)
We previously described an osteocalcin (OC) fibroblast growth factor (FGF) response element (FRE) DNA binding activity as a target of Msx2 transcriptional regulation. We now identify Ku70, Ku80, and Tbdn100, a variant of Tubedown-1, as constituents o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe5e3ee011e20d1ab3c1cbe028e58580
https://pubmed.ncbi.nlm.nih.gov/12145306
https://pubmed.ncbi.nlm.nih.gov/12145306
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 11(11)
Superprotein is a rapidly axonally transported protein that is conspicuously labeled with 35S-methionine supplied to the cell bodies of retinal ganglion cells. Superprotein candidates are apparent among the rapidly transported proteins of many neuron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952ca6af9ff4c26fcd915e5994239f7b
https://pubmed.ncbi.nlm.nih.gov/1941090
https://pubmed.ncbi.nlm.nih.gov/1941090
Autor:
Daniel Soppet, Karina F. Meiri, Paul S. Changelian, Arleen P. Loewy, Helen Valenza, Mark Willard
Publikováno v:
Brain research. 510(2)
GAP-43 is a neuronal phosphoprotein. Increased synthesis and axonal transport of GAP-43 has been associated with axon growth, and altered phosphorylation of GAP-43 has been associated with changes in synaptic efficacy. Here we report a rapid and effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b71c77ba0236e8ebb470c00fdab843
https://pubmed.ncbi.nlm.nih.gov/2139587
https://pubmed.ncbi.nlm.nih.gov/2139587