Galectin-1, -3 and -9 Expression and Clinical Significance in Squamous Cervical Cancer.

Autor: Simone Punt, Victor L Thijssen, Johannes Vrolijk, Cornelis D de Kroon, Arko Gorter, Ekaterina S Jordanova

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0129119 (2015)

Galectins are proteins that bind β-galactoside sugars and provide a new type of potential biomarkers and therapeutic targets in cancer. Galectin-1, -3 and -9 have become the focus of different research groups, but their expression and function in ce

Externí odkaz: https://doaj.org/article/f36b3e8b64124d438962e54484f92d91

A beneficial tumor microenvironment in oropharyngeal squamous cell carcinoma is characterized by a high T cell and low IL-17(+) cell frequency

Autor: Emilie A. C. Dronkers, Senada Koljenović, Robert J. Baatenburg de Jong, Renske Goedemans, Elisabeth Bloemena, Ekaterina S. Jordanova, Sjoerd H. van der Burg, Arko Gorter, Simone Punt, Peter J. F. Snijders, Marij J. P. Welters

Publikováno v: Cancer Immunology, Immunotherapy, 65(4), 393-403
Cancer Immunology, Immunotherapy, 65(4), 393-403. Springer Science and Business Media Deutschland GmbH
Punt, S, Dronkers, E A C, Welters, M J P, Goedemans, R, Koljenovic, S, Bloemena, E, Snijders, P J F, Gorter, A, van der Burg, S H, Baatenburg de Jong, R J & Jordanova, E S 2016, ' A beneficial tumor microenvironment in oropharyngeal squamous cell carcinoma is characterized by a high T cell and low IL-17(+) cell frequency ', Cancer Immunology, Immunotherapy, vol. 65, no. 4, pp. 393-403 . https://doi.org/10.1007/s00262-016-1805-x
Cancer immunology and immunotherapy, 65(4), 393-403. Springer Science and Business Media Deutschland GmbH
Cancer Immunology and Immunotherapy, 65(4), 393-403. Springer Science and Business Media Deutschland GmbH
Cancer Immunology Immunotherapy, 65(4), 393-403. Springer Science+Business Media
Punt, S, Dronkers, E A C, Welters, M J P, Goedemans, R, Koljenovic, S, Bloemena, E, Snijders, P J F, Gorter, A, van der Burg, S H, de Jong, R J B & Jordanova, E S 2016, ' A beneficial tumor microenvironment in oropharyngeal squamous cell carcinoma is characterized by a high T cell and low IL-17(+) cell frequency ', Cancer Immunology and Immunotherapy, vol. 65, no. 4, pp. 393-403 . https://doi.org/10.1007/s00262-016-1805-x
Cancer Immunology, Immunotherapy

Patients with HPV-positive oropharyngeal squamous cell carcinomas (OPSCCs) have a better prognosis than patients with non-HPV-induced OPSCC. The role of the immune response in this phenomenon is yet unclear. We studied the number of T cells, regulato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10072aeebdb0b973babc6ea732d4f59f
https://doi.org/10.1007/s00262-016-1805-x

Role of IL-12p40 in cervical carcinoma

Autor: Gemma G. Kenter, Arko Gorter, Simone Punt, H J M A A Zijlmans, J.B. Trimbos, Gert Jan Fleuren

Publikováno v: Zijlmans, H J M A A, Punt, S, Fleuren, G J, Trimbos, J B, Kenter, G G & Gorter, A 2012, ' Role of IL-12p40 in cervical carcinoma ', British Journal of Cancer, vol. 107, no. 12, pp. 1956-1962 . https://doi.org/10.1038/bjc.2012.488
British Journal of Cancer, 107(12), 1956-1962
British Journal of Cancer
British Journal of Cancer, 107(12), 1956-1962. Nature Publishing Group

Cervical cancer is a leading cause of morbidity and mortality among women worldwide, especially in the developing countries (Munoz, 2000; Rock et al, 2000). Infection with oncogenic types of human papillomavirus (HPV) is an important factor in the de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49e16fc9e704d27e4bdf965d1ad6e09
https://doi.org/10.1038/bjc.2012.488

Systemic and local human papillomavirus 16-specific T-cell immunity in patients with head and neck cancer

Autor: Hans Gelderblom, Arko Gorter, R.J.P. Briet, J.C. Jansen, A.P.M. Langeveld, J.W.R. Nortier, Renske Goedemans, Moniek Heusinkveld, S.H. van der Burg, Vincent T.H.B.M. Smit

Publikováno v: International Journal of Cancer

Squamous cell carcinomas of the head and neck (HNSCC), in particular those of the oropharynx, can be caused by human papilloma virus Type 16 (HPV16). Whereas these HPV-induced oropharyngeal carcinomas may express the HPV16 E6 and E7 oncoproteins and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99727ef464d2191a6633506f252da3b2
https://doi.org/10.1002/ijc.26497

Expression of Smad2 and Smad4 in cervical cancer: absent nuclear Smad4 expression correlates with poor survival

Autor: Gert Jan Fleuren, Sandra Uljee, Arko Gorter, H. Siebe Spijker, Ekaterina S. Jordanova, Willem E. Corver, Gemma G. Kenter, Judith N. Kloth

Publikováno v: Modern Pathology. 21:866-875

Alterations in transforming growth factor-beta signaling, due to a decrease in Smad2 and especially Smad4 expression, has primarily been reported in pancreatic and colorectal cancers, although loss of the chromosomal region 18q21.1, containing the lo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cad7c5860bb091b2b485f92a2a747c1
https://doi.org/10.1038/modpathol.2008.62