Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Arkadiusz W. Kulczyk"'
Autor:
Chao-Yu Yang, Chia-I Lien, Yi-Chun Tseng, Yi-Fan Tu, Arkadiusz W. Kulczyk, Yen-Chen Lu, Yin-Ting Wang, Tsung-Wei Su, Li-Chung Hsu, Yu-Chih Lo, Su-Chang Lin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Fas-associated protein with death domain (FADD), procaspase-8, and cellular FLICE-inhibitory proteins (cFLIP) assemble through death-effector domains (DEDs), directing death receptor signaling towards cell survival or apoptosis. Understandin
Externí odkaz:
https://doaj.org/article/9ebe13928bbd4e0f95f815de3b2c8bef
Autor:
Arkadiusz W. Kulczyk
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Laminins (Lm) are major components of basement membranes (BM), which polymerize to form a planar lattice on cell surface. Genetic alternations of Lm affect their oligomerization patterns and lead to failures in BM assembly manifesting in a g
Externí odkaz:
https://doaj.org/article/33ae248f7902452f8ae7ff0ac1961b1d
Autor:
Arkadiusz W. Kulczyk
Publikováno v:
Micromachines, Vol 15, Iss 9, p 1092 (2024)
The technical innovation of the last decade has provided novel tools that are now transforming the field of biophysics by bringing remarkable atomic level insights into the mechanisms employed by bio-micromachines to sustain life [...]
Externí odkaz:
https://doaj.org/article/b951628e5d2d4b1a9dad88fb380c83c1
Autor:
Arkadiusz W. Kulczyk, Karen K. McKee, Ximo Zhang, Iwona Bizukojc, Ying Q. Yu, Peter D. Yurchenco
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-7 (2023)
In this work the authors report the cryo-EM structure of the laminin polymer node and reveal the molecular basis of calcium-dependent formation of laminin lattice. The work provides insights into laminin polymerization defects manifesting in human di
Externí odkaz:
https://doaj.org/article/60769db0fb56402eb40aadb01cc00d25
Autor:
Megan C. DiIorio, Arkadiusz W. Kulczyk
Publikováno v:
Micromachines, Vol 14, Iss 9, p 1674 (2023)
Single particle cryo-electron microscopy (cryo-EM) has emerged as the prevailing method for near-atomic structure determination, shedding light on the important molecular mechanisms of biological macromolecules. However, the inherent dynamics and str
Externí odkaz:
https://doaj.org/article/897d0f862fe64f8499084b609cb73c27
Autor:
Megan C. DiIorio, Arkadiusz W. Kulczyk
Publikováno v:
Micromachines, Vol 14, Iss 1, p 118 (2022)
Biological macromolecules and assemblies precisely rearrange their atomic 3D structures to execute cellular functions. Understanding the mechanisms by which these molecular machines operate requires insight into the ensemble of structural states they
Externí odkaz:
https://doaj.org/article/da9d99b9c1c14894a00a6af8d844fe24
Autor:
Arkadiusz W. Kulczyk, Carlos Oscar S. Sorzano, Przemysław Grela, Marek Tchórzewski, Nilgun E. Tumer, Xiao-Ping Li
Publikováno v:
The Journal of biological chemistry. 299(1)
Shiga toxin 2a (Stx2a) is the virulence factor of enterohemorrhagic Escherichia coli. The catalytic A1 subunit of Stx2a (Stx2A1) interacts with the ribosomal P-stalk for loading onto the ribosome and depurination of the sarcin-ricin loop, which halts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2952714a353c67be1758b58f345b1c
https://pubmed.ncbi.nlm.nih.gov/36528064
https://pubmed.ncbi.nlm.nih.gov/36528064
Autor:
Stephen K. Burley, Helen M. Berman, Wah Chiu, Wei Dai, Justin W. Flatt, Brian P. Hudson, Jason T. Kaelber, Sagar D. Khare, Arkadiusz W. Kulczyk, Catherine L. Lawson, Grigore D. Pintilie, Andrej Sali, Brinda Vallat, John D. Westbrook, Jasmine Y. Young, Christine Zardecki
Publikováno v:
Biophysical reviews.
As a discipline, structural biology has been transformed by the three-dimensional electron microscopy (3DEM) “Resolution Revolution” made possible by convergence of robust cryo-preservation of vitrified biological materials, sample handling syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e46fa4358f0b1393080bb56d88dd8a8d
https://pubmed.ncbi.nlm.nih.gov/36474933
https://pubmed.ncbi.nlm.nih.gov/36474933
Autor:
Arkadiusz W. Kulczyk, Megan C. DiIorio
Publikováno v:
Journal of visualized experiments : JoVE. (179)
Recent advances in both instrumentation and image processing software have made single-particle cryo-electron microscopy (cryo-EM) the preferred method for structural biologists to determine high-resolution structures of a wide variety of macromolecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3654affecec7e9d471e36dc0a91cdfee
https://pubmed.ncbi.nlm.nih.gov/35104261
https://pubmed.ncbi.nlm.nih.gov/35104261
Autor:
Arkadiusz W. Kulczyk, Thomas Leustek
Publikováno v:
Journal of Biological Chemistry. 298:101973
Oxidation of protein methionines to methionine sulfoxides can result in protein structural alterations with a wide variety of biological implications. Factors that determine susceptibility to oxidation are not well understood. The recent JBC Editors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1c2fddde9f7e23a4c0caed1b4cf186
https://doi.org/10.1016/j.jbc.2022.101973
https://doi.org/10.1016/j.jbc.2022.101973