Výsledky vyhledávání - "Arkadiusz G. Kl̶opocki"

Akademický článek

P-selectin glycoprotein ligand-1 forms dimeric interactions with E-selectin but monomeric interactions with L-selectin on cell surfaces.

Autor: Yan Zhang, Ning Jiang, Veronika I Zarnitsyna, Arkadiusz G Klopocki, Rodger P McEver, Cheng Zhu

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e57202 (2013)

Interactions of selectins with cell surface glycoconjugates mediate the first step of the adhesion and signaling cascade that recruits circulating leukocytes to sites of infection or injury. P-selectin dimerizes on the surface of endothelial cells an

Externí odkaz: https://doaj.org/article/4c94e86ded3e41579aee661030a7d079

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Circulating soluble P-selectin must dimerize to promote inflammation and coagulation in mice

Autor: Arkadiusz G. Klopocki, Nan Zhang, Padmaja Mehta-D’souza, Sumith R. Panicker, Rodger P. McEver, Bojing Shao

Publikováno v: Blood. 130:181-191

Leukocyte adhesion to P-selectin on activated platelets and endothelial cells induces shedding of the P-selectin ectodomain into the circulation. Plasma soluble P-selectin (sP-selectin) is elevated threefold to fourfold in patients with cardiovascula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71648afcaae91c66f6abc7cab0b09ec5
https://doi.org/10.1182/blood-2017-02-770479

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Brief Report: Patients With Primary Sjögren's Syndrome Who Are Positive for Autoantibodies to Tripartite Motif-Containing Protein 38 Show Greater Disease Severity

Publikováno v: Arthritis & Rheumatology. 68:724-729

Objective Autoantibodies reactive with Ro52 (tripartite motif−containing protein 21 [TRIM21]) are detected in 70% of patients with primary Sjogren's syndrome (SS). TRIM21 belongs to a 34-member C-IV family of TRIM proteins. Although autoantibodies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b447c7c03e8ed243d11dd372e952bb56
https://doi.org/10.1002/art.39497

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Signal-dependent Slow Leukocyte Rolling Does Not Require Cytoskeletal Anchorage of P-selectin Glycoprotein Ligand-1 (PSGL-1) or Integrin αLβ2

Autor: William H. Rodgers, Arkadiusz G. Klopocki, Bojing Shao, Rodger P. McEver, Tadayuki Yago, Phillip A. Coghill, David W. Schmidtke, Padmaja Mehta-D’souza

Publikováno v: Journal of Biological Chemistry. 287:19585-19598

In inflamed venules, neutrophils roll on P- or E-selectin, engage P-selectin glycoprotein ligand-1 (PSGL-1), and signal extension of integrin α(L)β(2) in a low affinity state to slow rolling on intercellular adhesion molecule-1 (ICAM-1). Cytoskelet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716544c428caf08455f59d76de9ff0c7
https://doi.org/10.1074/jbc.m112.361519

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Cytoplasmic Domain of P-selectin Glycoprotein Ligand-1 Facilitates Dimerization and Export from the Endoplasmic Reticulum

Autor: Zhenghui Liu, Arkadiusz G. Klopocki, Tadayuki Yago, Gurunadh Reddy Chichili, Ying Wang, Jonathan J. Miner, Rodger P. McEver, William H. Rodgers, Lijun Xia, J. Michael McDaniel, Bojing Shao

Publikováno v: Journal of Biological Chemistry. 286:9577-9586

P-selectin glycoprotein ligand-1 (PSGL-1) is a homodimeric transmembrane mucin on leukocytes. During inflammation, reversible interactions of PSGL-1 with selectins mediate leukocyte rolling on vascular surfaces. The transmembrane domain of PSGL-1 is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a58b59e280f3f85b42aa38df72aecc
https://doi.org/10.1074/jbc.m110.208777

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Flow-enhanced adhesion regulated by a selectin interdomain hinge

Autor: Jizhong Lou, Tadayuki Yago, Wei Chen, Nicolai V. Bovin, Padmaja Mehta, Rodger P. McEver, Cheng Zhu, Arkadiusz G. Klopocki, Veronika I. Zarnitsyna

Publikováno v: The Journal of Cell Biology

L-selectin requires a threshold shear to enable leukocytes to tether to and roll on vascular surfaces. Transport mechanisms govern flow-enhanced tethering, whereas force governs flow-enhanced rolling by prolonging the lifetimes of L-selectin–ligand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca449263abee27a968de10728b02a4c
https://doi.org/10.1083/jcb.200606056

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Low Force Decelerates L-selectin Dissociation from P-selectin Glycoprotein Ligand-1 and Endoglycan

Autor: Cheng Zhu, Tadayuki Yago, Arkadiusz G. Klopocki, Claudia B. Fieger, Krishna K. Sarangapani, Steven D. Rosen, Rodger P. McEver, Michael B. Lawrence

Publikováno v: Journal of Biological Chemistry. 279:2291-2298

Selectin-ligand interactions mediate the tethering and rolling of circulating leukocytes on vascular surfaces during inflammation and immune surveillance. To support rolling, these interactions are thought to have rapid off-rates that increase slowly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87455e5d733743624efe47956f8bc0b0
https://doi.org/10.1074/jbc.m310396200

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Catch bonds govern adhesion through L-selectin at threshold shear

Autor: C. Diana Wey, Rodger P. McEver, Cheng Zhu, Jianhua Wu, Tadayuki Yago, Arkadiusz G. Klopocki

Publikováno v: The Journal of Cell Biology

Flow-enhanced cell adhesion is an unexplained phenomenon that might result from a transport-dependent increase in on-rates or a force-dependent decrease in off-rates of adhesive bonds. L-selectin requires a threshold shear to support leukocyte rollin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af959bf693893a55eeff3f064c22bf51
http://europepmc.org/articles/PMC2172126

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Autor: Maciej Ugorski, Anna Laskowska, Fritz Grunert, Arkadiusz G. Kl̶opocki, Jan Salwa, Anna Krop-Watorek

Publikováno v: Cancer Letters. 139:15-22

CEA family proteins from human urothelial cell lines of different transformation grades were characterized by flow cytometry and Western blotting using monoclonal antibodies: 26/3/13, D14HD11, 9A6 and 4/3/17. The following observations were made: (i)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d1d89106a52d8c120068b8a27d7883
https://doi.org/10.1016/s0304-3835(98)00363-2

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