Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Arkadiusz Chworos"'
Autor:
Roza Pawlowska, Ewa Radzikowska-Cieciura, Sepideh Jafari, Julia Fastyn, Eliza Korkus, Edyta Gendaszewska-Darmach, Gangyin Zhao, Ewa Snaar-Jagalska, Arkadiusz Chworos
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract Recent data indicate that extracellular ATP affects wound healing efficacy via P2Y2-dependent signaling pathway. In the current work, we propose double-modified ATP analogue—alpha-thio-beta,gamma-methylene-ATP as a potential therapeutic ag
Externí odkaz:
https://doaj.org/article/67dd6a1751c240e6ac21ad59674f1146
Autor:
Irena Bak-Sypien, Tomasz Pawlak, Piotr Paluch, Aneta Wroblewska, Rafał Dolot, Aleksandra Pawlowicz, Małgorzata Szczesio, Ewelina Wielgus, Sławomir Kaźmierski, Marcin Górecki, Roza Pawlowska, Arkadiusz Chworos, Marek J. Potrzebowski
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Cyclic tetrapeptides c(Pro-Phe-Pro-Phe) obtained by the mechanosynthetic method using a ball mill were isolated in a pure stereochemical form as a homochiral system (all L-amino acids, sample A) and as a heterochiral system with D configurat
Externí odkaz:
https://doaj.org/article/c063d4a0543840af82f2c1cd7682cbce
Autor:
Sujoy Das, Marcelina Strachanowska, Piotr Wadowski, Michał Juszczak, Paulina Tokarz, Aneta Kosińska, Marcin Palusiak, Agnieszka J. Rybarczyk-Pirek, Kinga Wzgarda-Raj, Saranya Vasudevan, Arkadiusz Chworos, Katarzyna Woźniak, Bogna Rudolf
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract In these studies, we designed and investigated the potential anticancer activity of five iron(II) cyclopentadienyl complexes bearing different phosphine and phosphite ligands. All complexes were characterized with spectroscopic analysis viz.
Externí odkaz:
https://doaj.org/article/7c6a1f66b3bc4430a4b738b621a53c21
Autor:
Roza Pawlowska, Anna Graczyk, Ewa Radzikowska-Cieciura, Ewelina Wielgus, Rafal Madaj, Arkadiusz Chworos
Publikováno v:
ACS Omega, Vol 9, Iss 8, Pp 9348-9356 (2024)
Externí odkaz:
https://doaj.org/article/5b65db563a1f4046b8b8997417202b7c
Publikováno v:
Molecules, Vol 29, Iss 2, p 338 (2024)
In silico studies were performed to assess the binding affinity of selected organophosphorus compounds toward the acetylcholinesterase enzyme (AChE). Quantum mechanical calculations, molecular docking, and molecular dynamics (MD) with molecular mecha
Externí odkaz:
https://doaj.org/article/857b90efc08243caba40679ef364867c
Autor:
Aneta Kosińska, David Virieux, Jean-Luc Pirat, Kamila Czarnecka, Małgorzata Girek, Paweł Szymański, Sławomir Wojtulewski, Saranya Vasudevan, Arkadiusz Chworos, Bogna Rudolf
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8091 (2022)
The quest to find new inhibitors of biologically relevant targets is considered an important strategy to introduce new drug candidates for the treatment of neurodegenerative diseases. A series of (aminomethyl)benzylphosphonates 8a–c and their metal
Externí odkaz:
https://doaj.org/article/0fef93b3d800410392eab1339738888e
Publikováno v:
Biomolecules, Vol 11, Iss 8, p 1104 (2021)
Tissue-nonspecific alkaline phosphatase (TNAP) is known to be involved in the degradation of extracellular ATP via the hydrolysis of pyrophosphate (PPi). We investigated, using three different computational methods, namely molecular docking, thermody
Externí odkaz:
https://doaj.org/article/68e51727bd734e97bb098eae234b76d6
Autor:
Aneta Wróblewska, Justyna Śniechowska, Sławomir Kaźmierski, Ewelina Wielgus, Grzegorz D. Bujacz, Grzegorz Mlostoń, Arkadiusz Chworos, Justyna Suwara, Marek J. Potrzebowski
Publikováno v:
Pharmaceutics, Vol 12, Iss 4, p 359 (2020)
Two, well defined binary crystals with 1-Hydroxy-4,5-Dimethyl-Imidazole 3-Oxide (HIMO) as coformer and thiobarbituric acid (TBA) as well barbituric acid (BA) as Active Pharmaceutical Ingredients (APIs) were obtained by cocrystallization (from methano
Externí odkaz:
https://doaj.org/article/9c44809a15464ef4a281f0aba56cc9c0
Highly Fluorescent Distyrylnaphthalene Derivatives as a Tool for Visualization of Cellular Membranes
Publikováno v:
Materials, Vol 13, Iss 4, p 951 (2020)
Fluorescent imaging, which is an important interdisciplinary field bridging research from organic chemistry, biochemistry and cell biology has been applied for multi-dimensional detection, visualization and characterization of biological structures a
Externí odkaz:
https://doaj.org/article/73c5083fee52481d80c12e263da219b2
Publikováno v:
Molecules, Vol 25, Iss 1, p 204 (2020)
Development of nanotechnology has become prominent in many fields, such as medicine, electronics, production of materials, and modern drugs. Nanomaterials and nanoparticles have gained recognition owing to the unique biochemical and physical properti
Externí odkaz:
https://doaj.org/article/a25e0fcb6ad74ff0a9239dbbbd28b76a