Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Arkadij Sobolev"'
Autor:
Aiva Plotniece, Arkadij Sobolev, Claudiu T. Supuran, Fabrizio Carta, Fredrik Björkling, Henrik Franzyk, Jari Yli-Kauhaluoma, Koen Augustyns, Paul Cos, Linda De Vooght, Matthias Govaerts, Juliana Aizawa, Päivi Tammela, Raivis Žalubovskis
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Natural products and analogues are a source of antibacterial drug discovery. Considering drug resistance levels emerging for antibiotics, identification of bacterial metalloenzymes and the synthesis of selective inhibitors are interesting for antibac
Externí odkaz:
https://doaj.org/article/d7d196adf4464caaa61e8aa20fcbc597
Autor:
Ance Bārzdiņa, Aiva Plotniece, Arkadij Sobolev, Karlis Pajuste, Dace Bandere, Agnese Brangule
Publikováno v:
Antibiotics, Vol 13, Iss 4, p 305 (2024)
Gentamicin is an essential broad-spectrum aminoglycoside antibiotic that is used in over 40 clinical conditions and has shown activity against a wide range of nosocomial, biofilm-forming, multi-drug resistant bacteria. Nevertheless, the low cellular
Externí odkaz:
https://doaj.org/article/5ef1f9870ec64b159e2573cd4c6cbea6
Publikováno v:
Molecules, Vol 29, Iss 1, p 161 (2023)
One of the most important steps in the synthesis of 1,4-dihydropyridine (1,4-DHP) amphiphiles is the bromination of methyl groups in positions 2 and 6 of the entire ring. However, up to now, only N-bromosuccinimide was mainly used for bromination 1,4
Externí odkaz:
https://doaj.org/article/c03c16c51ad243c6aa50738972163d4b
Autor:
Reinis Putralis, Ksenija Korotkaja, Martins Kaukulis, Zhanna Rudevica, Juris Jansons, Olga Nilova, Martins Rucins, Laura Krasnova, Ilona Domracheva, Mara Plotniece, Karlis Pajuste, Arkadij Sobolev, Felikss Rumnieks, Laura Bekere, Anna Zajakina, Aiva Plotniece, Gunars Duburs
Publikováno v:
Pharmaceuticals, Vol 16, Iss 9, p 1245 (2023)
A set of styrylpyridinium (SP) compounds was synthesised in order to study their spectroscopic and cell labelling properties. The compounds comprised different electron donating parts (julolidine, p-dimethylaminophenyl, p-methoxyphenyl, 3,4,5-trimeth
Externí odkaz:
https://doaj.org/article/c72d1fe3c07644e092e19883f53d7ef5
Autor:
Reinis Ozolins, Mara Plotniece, Karlis Pajuste, Reinis Putralis, Nadiia Pikun, Arkadij Sobolev, Aiva Plotniece, Martins Rucins
Publikováno v:
Molbank, Vol 2022, Iss 3, p M1438 (2022)
A synthesis of a cationic moiety and fluorescent moieties containing amphiphilic 1,4-dihydropyridine (1,4-DHP) derivatives was performed starting with the Hantzsch-type cyclization of dodecyl acetoacetate, phenylaldehyde and ammonium acetate. Bromina
Externí odkaz:
https://doaj.org/article/2104371383274a49a5813a833e166842
Autor:
Nadiia Pikun, Davis Lacis, Arkadij Sobolev, Martins Rucins, Mara Plotniece, Karlis Pajuste, Aiva Plotniece
Publikováno v:
Molbank, Vol 2022, Iss 3, p M1402 (2022)
A synthesis of 3-(3,5-difluoro-3,5-bis((alkoxy)carbonyl)-2,6-dioxoheptan-4-yl)-1-methylpyridin-1-ium iodides with ethyl or nonyl ester groups at positions 3 and 5 was performed. Treatment of the corresponding 2’,6’-dimethyl-1’,4’-dihydro-[3,4
Externí odkaz:
https://doaj.org/article/f8216c459a8241149d59226acb9ecb9a
Autor:
Martins Rucins, Martins Kaukulis, Aiva Plotniece, Karlis Pajuste, Nadiia Pikun, Arkadij Sobolev
Publikováno v:
Molbank, Vol 2022, Iss 3, p M1396 (2022)
Synthesis of a double-charged cationic amphiphilic 1,4-dihydropyridine derivative with dodecyl ester groups at positions 3 and 5 of the 1,4-DHP ring was performed starting from Hantzsch type cyclization of dodecyl acetoacetate, 2-naphthaldehyde and a
Externí odkaz:
https://doaj.org/article/d3cbc1af67dd430ebd64bd67ff91cb20
Autor:
Martins Rucins, Roman Rodik, Aiva Plotniece, Nadiia Pikun, Mara Plotniece, Arkadij Sobolev, Vitaly Kalchenko, Karlis Pajuste
Publikováno v:
Data in Brief, Vol 41, Iss , Pp 107988- (2022)
In this data file the characterisation of nanoformulations obtained from calix[4]arene/1,4-dihydropyridine (1,4-DHP) compositions in the various component ratio in an aqueous medium was performed by dynamic light scattering (DLS) technique. The hydro
Externí odkaz:
https://doaj.org/article/852bf31691b94c169c85777ccf2f6205
Autor:
Martins Rucins, Karlis Pajuste, Aiva Plotniece, Nadiia Pikun, Roman Rodik, Sergiy Vyshnevskiy, Arkadij Sobolev
Publikováno v:
Molbank, Vol 2022, Iss 1, p M1311 (2021)
In the present work, construction of double-charged cationic amphiphilic 1,1′-{[3,5-bis(dodecyl¬oxy-carbonyl)-4-(thiophen-3-yl)-1,4-dihydropyridine-2,6-diyl]bis-(methylene)}bis(pyridin-1-ium) dibromide (7) was performed in four steps. Dodecyl 3-ox
Externí odkaz:
https://doaj.org/article/a6f4253753be4aeaa6ecd79786406677
Autor:
Karina Spunde, Brigita Vigante, Unda Nelda Dubova, Anda Sipola, Irena Timofejeva, Anna Zajakina, Juris Jansons, Aiva Plotniece, Karlis Pajuste, Arkadij Sobolev, Ruslan Muhamadejev, Kristaps Jaudzems, Gunars Duburs, Tatjana Kozlovska
Publikováno v:
Pharmaceuticals, Vol 15, Iss 7, p 773 (2022)
Capsid assembly modulators (CAMs) have emerged as a promising class of antiviral agents. We studied the effects of twenty-one newly designed and synthesized CAMs including heteroaryldihydropyrimidine compounds (HAPs), their analogs and standard compo
Externí odkaz:
https://doaj.org/article/5b764d434c0343ef92d6e057be5efee9