Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Arkadi, Manukyan"'
Autor:
Nadine Michel, Heather M. Raimer Young, Naomi D. Atkin, Umar Arshad, Reem Al-Humadi, Sandeep Singh, Arkadi Manukyan, Lana Gore, Ian E. Burbulis, Yuh-Hwa Wang, Michael J. McConnell
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Neurons are overproduced during cerebral cortical development. Neural progenitor cells (NPCs) divide rapidly and incur frequent DNA double-strand breaks (DSBs) throughout cortical neurogenesis. Although half of the neurons born during neurod
Externí odkaz:
https://doaj.org/article/afbddd025bee472c8522a305ded18559
Autor:
Anita Salamon, Kirill S. Lobachev, Karol Szlachta, Heather M Raimer, Arkadi Manukyan, Yuh-Hwa Wang, Wenying Guo, Sandeep Singh
Publikováno v:
Nucleic Acids Research
DNA double-stranded breaks (DSBs) trigger human genome instability, therefore identifying what factors contribute to DSB induction is critical for our understanding of human disease etiology. Using an unbiased, genome-wide approach, we found that gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0144379b630550b75fa2922a13ab3b8
http://europepmc.org/articles/PMC7337936
http://europepmc.org/articles/PMC7337936
Autor:
Stefan Bekiranov, Arkadi Manukyan, Sandeep Singh, Yuh-Hwa Wang, Karol Szlachta, Heather M Raimer, Manikarna Dinda
Publikováno v:
J Biol Chem
DNA double-stranded breaks (DSBs) are strongly associated with active transcription, and promoter-proximal pausing of RNA polymerase II (Pol II) is a critical step in transcriptional regulation. Mapping the distribution of DSBs along actively express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7865dc6de0ba638ef1aaf0837ccd81d
https://europepmc.org/articles/PMC7086017/
https://europepmc.org/articles/PMC7086017/
Publikováno v:
Chromosoma. 127:375-386
Assembly of the mitotic spindle is essential for proper chromosome segregation during mitosis. Maintenance of spindle poles requires precise regulation of kinesin- and dynein-generated forces, and improper regulation of these forces disrupts pole int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba817091ae696cec35b5c3fe348148b
https://doi.org/10.1007/s00412-018-0670-0
https://doi.org/10.1007/s00412-018-0670-0
Autor:
Ann Sutherland, Tiffany A. Melhuish, Arkadi Manukyan, Kenichiro Taniguchi, David Wotton, Anoush E. Anderson, Anne L. Carlton
Publikováno v:
European Journal of Human Genetics. 25:208-215
Holoprosencephaly (HPE) is a prevalent craniofacial developmental disorder that has both genetic and environmental causes. The gene encoding TG-interacting factor 1 (TGIF1) is among those that are routinely screened in HPE patients. However, the mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e79fcccd9fe06dabc9022fb59d1ad5dc
https://doi.org/10.1038/ejhg.2016.164
https://doi.org/10.1038/ejhg.2016.164
Autor:
Roger Abounader, Anant Shah, Arkadi Manukyan, David Wotton, Ying Zhang, Tiffany A. Melhuish, Izabela Kowalczyk
Publikováno v:
Biochimica et biophysica acta. Gene regulatory mechanisms. 1861(11)
Myelin transcription factor 1 (Myt1) and Myt1l (Myt1-like) are zinc finger transcription factors that regulate neuronal differentiation. Reduced Myt1l expression has been implicated in glioblastoma (GBM), and the related St18 was originally identifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097ef9031e8fab08e3d8b141901ed37f
https://pubmed.ncbi.nlm.nih.gov/30312684
https://pubmed.ncbi.nlm.nih.gov/30312684
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1524
The budding yeast Saccharomyces cerevisiae and fission yeast Schizosaccharomyces pombe are amongst the simplest and most powerful model systems for studying the genetics of cell cycle control. Because yeast grows very rapidly in a simple and economic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6c5ec5eda6206dfe694d8a8c91ae57c8
https://pubmed.ncbi.nlm.nih.gov/27815906
https://pubmed.ncbi.nlm.nih.gov/27815906
Publikováno v:
Methods in Molecular Biology ISBN: 9781493966028
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89cc18cd10bc041e2f506b2397ccf87e
https://doi.org/10.1007/978-1-4939-6603-5_14
https://doi.org/10.1007/978-1-4939-6603-5_14
Autor:
Arkadi Manukyan, Huzefa Dungrawala, Brian Nordstrom, Jill Wright, Lesley Abraham, Micah Montgomery, Brandt L. Schneider, K. Wyatt McMahon
Publikováno v:
Yeast. 28:661-671
A consortium of yeast geneticists have created -6000 individual ORF deletions, representing > 96% of the currently verified or predicted ORFs in S. cerevisiae. Importantly, molecular barcodes (each a unique 20 bp sequence termed either Uptag or Downt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a29e23f918554adc8b25bb9060b2b44
https://doi.org/10.1002/yea.1894
https://doi.org/10.1002/yea.1894
Autor:
Arkadi Manukyan, Holly Mead, Wesley Lane, Huzefa Dungrawala, Lesley Abraham, Hui Hua, Jingye Yang, Brandt L. Schneider, Jill Wright
Publikováno v:
Cell Cycle. 10:144-155
Yeast cells, like mammalian cells, enlarge steadily as they age. Unabated cell growth can promote cellular senescence; however, the significance of the relationship between size and cellular lifespan is not well understood. Herein, we report a geneti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba785a6dc94dde026a5a85775d00922
https://doi.org/10.4161/cc.10.1.14455
https://doi.org/10.4161/cc.10.1.14455