Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Arka P. Ray"'
Autor:
Naveen Thakur, Arka P. Ray, Liam Sharp, Beining Jin, Alexander Duong, Niloofar Gopal Pour, Samuel Obeng, Anuradha V. Wijesekara, Zhan-Guo Gao, Christopher R. McCurdy, Kenneth A. Jacobson, Edward Lyman, Matthew T. Eddy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
In cell membranes, lipids are ubiquitous regulators of protein function. Here, Thakur et al. observe anionic phospholipids impact the conformational dynamics of a class A human GPCR.
Externí odkaz:
https://doaj.org/article/c97c975e0e3f4ff491e2f710139cacce
Autor:
Shushu Wei, Niloofar Gopal Pour, Sriram Tiruvadi-Krishnan, Arka Prabha Ray, Naveen Thakur, Matthew T. Eddy, Rajan Lamichhane
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract Mutations that constitutively activate G protein-coupled receptors (GPCRs), known as constitutively activating mutations (CAMs), modify cell signaling and interfere with drugs, resulting in diseases with limited treatment options. We utilize
Externí odkaz:
https://doaj.org/article/a5791267b9534817a20ef741b4663262
Publikováno v:
Biophysical Reports, Vol 2, Iss 3, Pp 100066- (2022)
Membrane protein conformations and dynamics are driven by the protein-lipid interactions occurring within the local environment of the membrane. These environments remain challenging to accurately capture in structural and biophysical experiments usi
Externí odkaz:
https://doaj.org/article/68cfd89096dc4691a5b32b608e2d402f
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101535- (2022)
Summary: We describe production of the human A2A adenosine receptor (A2AAR), a class A G protein-coupled receptor (GPCR) for 19F-NMR and single-molecule fluorescence (SMF) spectroscopy. We explain in detail steps shared between the two sample prepara
Externí odkaz:
https://doaj.org/article/15f241271f524010b982028ab1f807e4
Autor:
Guillaume, Ferré, Kara, Anazia, Larissa O, Silva, Naveen, Thakur, Arka P, Ray, Matthew T, Eddy
Publikováno v:
Cell reports. 41(12)
G protein-coupled receptor (GPCR) conformational plasticity enables formation of ternary signaling complexes with intracellular proteins in response to binding extracellular ligands. We investigate the dynamic process of GPCR complex formation in sol
Autor:
Shushu Wei, Naveen Thakur, Arka P. Ray, Beining Jin, Samuel Obeng, Christopher R. McCurdy, Lance R. McMahon, Hugo Gutiérrez-de-Terán, Matthew T. Eddy, Rajan Lamichhane
Publikováno v:
Structure
A more complete depiction of protein energy landscapes includes the identification of different function-related conformational states and the determination of the pathways connecting them. We used total internal reflection fluorescence (TIRF) imagin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b487b67724361a44922a7fea0281569
https://europepmc.org/articles/PMC8897252/
https://europepmc.org/articles/PMC8897252/
Publikováno v:
Biomolecules, Vol 11, Iss 5, p 632 (2021)
G protein-coupled receptors (GPCRs) bind a broad array of extracellular molecules and transmit intracellular signals that initiate physiological responses. The signal transduction functions of GPCRs are inherently related to their structural plastici
Externí odkaz:
https://doaj.org/article/e8feeff086dd406bb6988b502db5228a