Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Arjun Baghela"'
Autor:
Arjun Baghela, Andy An, Peter Zhang, Erica Acton, Jeff Gauthier, Elsa Brunet-Ratnasingham, Travis Blimkie, Gabriela Cohen Freue, Daniel Kaufmann, Amy H. Y. Lee, Roger C. Levesque, Robert E. W. Hancock
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Severely-afflicted COVID-19 patients can exhibit disease manifestations representative of sepsis, including acute respiratory distress syndrome and multiple organ failure. We hypothesized that diagnostic tools used in managing all-cause seps
Externí odkaz:
https://doaj.org/article/4a81a36a072744c09fdb25d7139cf960
Persistence is key: unresolved immune dysfunction is lethal in both COVID-19 and non-COVID-19 sepsis
Autor:
Andy Y. An, Arjun Baghela, Peter Zhang, Reza Falsafi, Amy H. Lee, Uriel Trahtemberg, Andrew J. Baker, Claudia C. dos Santos, Robert E. W. Hancock
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSevere COVID-19 and non-COVID-19 pulmonary sepsis share pathophysiological, immunological, and clinical features, suggesting that severe COVID-19 is a form of viral sepsis. Our objective was to identify shared gene expression trajectories
Externí odkaz:
https://doaj.org/article/72fa51db86cf4ba7bc093529d5e48e74
Autor:
Andy Yi An, Arjun Baghela, Peter G. Y. Zhang, Travis M. Blimkie, Jeff Gauthier, Daniel Elias Kaufmann, Erica Acton, Amy H. Y. Lee, Roger C. Levesque, Robert E. W. Hancock
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionPersistent symptoms after COVID-19 infection (“long COVID”) negatively affects almost half of COVID-19 survivors. Despite its prevalence, its pathophysiology is poorly understood, with multiple host systems likely affected. Here, we f
Externí odkaz:
https://doaj.org/article/847c7a1bfa6448129c35b711a7569eb0
Autor:
Andy Y. An, Arjun Baghela, Peter Zhang, Reza Falsafi, Amy H. Lee, Uriel Trahtemberg, Andrew J. Baker, Claudia C. dos Santos, Robert E. W. Hancock
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSevere COVID-19 and non-COVID-19 pulmonary sepsis share pathophysiological, immunological, and clinical features. To what extent they share mechanistically-based gene expression trajectories throughout hospitalization was unknown. Our obj
Externí odkaz:
https://doaj.org/article/7240eb0474994e7cbedec8b7e33d80b4
Autor:
Daniel Pletzer, Travis M. Blimkie, Heidi Wolfmeier, Yicong Li, Arjun Baghela, Amy H. Y. Lee, Reza Falsafi, Robert E. W. Hancock
Publikováno v:
mSystems, Vol 5, Iss 4 (2020)
ABSTRACT The bacterial stringent stress response, mediated by the signaling molecule guanosine tetraphosphate, ppGpp, has recently gained attention as being important during normal cellular growth and as a potential new therapeutic target, which warr
Externí odkaz:
https://doaj.org/article/94197f6636d04bce954a708fe7e6bc0a
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Systems biology is an approach to interrogate complex biological systems through large-scale quantification of numerous biomolecules. The immune system involves >1,500 genes/proteins in many interconnected pathways and processes, and a systems-level
Externí odkaz:
https://doaj.org/article/e6e94066f3f940da9c7dc207d8dca77d
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Pseudomonas aeruginosa is an opportunistic pathogen that is a major cause of nosocomial and chronic infections contributing to morbidity and mortality in cystic fibrosis patients. One of the reasons for its success as a pathogen is its ability to ada
Externí odkaz:
https://doaj.org/article/787f31d3f63d4d6aa76e7505056a6d9b
Autor:
Maryam Nesvaderani, Bhavjinder K Dhillon, Tracy Chew, Benjamin Tang, Arjun Baghela, Robert EW Hancock, Guy D Eslick, Michael Cox
Publikováno v:
Journal of the American College of Surgeons. 234:803-815
Determining the risk of developing severe acute pancreatitis (AP) on presentation to hospital is difficult but vital to enable early management decisions that reduce morbidity and mortality. The objective of this study was to determine global gene ex
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Frontiers in Microbiology
Frontiers in Microbiology
Bacterial biofilms are complex and highly antibiotic-resistant aggregates of microbes that form on surfaces in the environment and body including medical devices. They are key contributors to the growing antibiotic resistance crisis and account for t
Autor:
Arjun Baghela, Olga M. Pena, Amy H. Lee, Beverlie Baquir, Reza Falsafi, Andy An, Susan W. Farmer, Andrew Hurlburt, Alvaro Mondragon-Cardona, Juan Diego Rivera, Andrew Baker, Uriel Trahtemberg, Maryam Shojaei, Carlos Eduardo Jimenez-Canizales, Claudia C. dos Santos, Benjamin Tang, Hjalmar R. Bouma, Gabriela V. Cohen Freue, Robert E.W. Hancock
Publikováno v:
EBioMedicine
EBioMedicine, 75:103776. ELSEVIER SCIENCE BV
EBioMedicine, 75:103776. ELSEVIER SCIENCE BV
Background Inter-individual variability during sepsis limits appropriate triage of patients. Identifying, at first clini-cal presentation, gene expression signatures that predict subsequent severity will allow clinicians to identify the most at-risk