A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling

Autor: Jason A. Hackney, Haridha Shivram, Jason Vander Heiden, Chris Overall, Luz Orozco, Xia Gao, Eugene Kim, Nathan West, Aditi Qamra, Diana Chang, Arindam Chakrabarti, David F. Choy, Alexis J. Combes, Tristan Courau, Gabriela K. Fragiadakis, Arjun Arkal Rao, Arja Ray, Jessica Tsui, Kenneth Hu, Nicholas F. Kuhn, Matthew F. Krummel, David J. Erle, Kirsten Kangelaris, Aartik Sarma, Zoe Lyon, Carolyn S. Calfee, Prescott G. Woodruff, Rajani Ghale, Eran Mick, Ashley Byrne, Beth Shoshana Zha, Charles Langelier, Carolyn M. Hendrickson, Monique G.P. van der Wijst, George C. Hartoularos, Tianna Grant, Raymund Bueno, David S. Lee, John R. Greenland, Yang Sun, Richard Perez, Anton Ogorodnikov, Alyssa Ward, Chun Jimmie Ye, Thiru Ramalingam, Jacqueline M. McBride, Fang Cai, Anastasia Teterina, Min Bao, Larry Tsai, Ivan O. Rosas, Aviv Regev, Sharookh B. Kapadia, Rebecca N. Bauer, Carrie M. Rosenberger, Yumiko Abe-Jones, Michael Adkisson, K. Mark Ansel, Saurabh Asthana, Alexander Beagle, Sharvari Bhide, Cathy Cai, Saharai Caldera, Maria Calvo, Sidney A. Carrillo, Suzanna Chak, Stephanie Christenson, Zachary Collins, Spyros Darmanis, Angela Detweiler, Catherine DeVoe, Walter Eckalbar, Jeremy Giberson, Ana Gonzalez, Gracie Gordon, Paula Hayakawa Serpa, Alejandra Jauregui, Chayse Jones, Serena Ke, Divya Kushnoor, Tasha Lea, Deanna Lee, Aleksandra Leligdowicz, Yale Liu, Salman Mahboob, Lenka Maliskova, Michael Matthay, Elizabeth McCarthy, Priscila Muñoz-Sandoval, Norma Neff, Viet Nguyen, Nishita Nigam, Randy Parada, Maira Phelps, Logan Pierce, Priya Prasad, Sadeed Rashid, Gabriella Reeder, Nicklaus Rodriguez, Bushra Samad, Andrew Schroeder, Cole Shaw, Alan Shen, Austin Sigman, Pratik Sinha, Matthew Spitzer, Sara Sunshine, Kevin Tang, Luz Torres Altamirano, Alexandra Tsitsiklis, Erden Tumurbaatar, Vaibhav Upadhyay, Alexander Whatley, Andrew Willmore, Michael Wilson, Juliane Winkler, Kristine Wong, Kimberly Yee, Michelle Yu, Mingyue Zhou, Wandi S. Zhu

Publikováno v: iScience, Vol 26, Iss 10, Pp 107813- (2023)

Summary: Altered myeloid inflammation and lymphopenia are hallmarks of severe infections. We identified the upregulated EN-RAGE gene program in airway and blood myeloid cells from patients with acute lung injury from SARS-CoV-2 or other causes across

Externí odkaz: https://doaj.org/article/9fcf76e7c2d9439cbd17b0a0b7fa8d89

Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01.

Autor: Weiner J; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Core Unit Bioinformatics Berlin, DE 10178, Germany., Suwalski P; Department of Cardiology, Charite Universitaetsmedizin Berlin, DE 12203, Germany.; Berliner Simulations- und Trainingszentrum, Charite, Berlin, DE 10117, Germany., Holtgrewe M; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Core Unit Genomics Berlin, DE 10178, Germany., Rakitko A; Genotek Ltd., Nastavnicheskii pereulok 17/1, R 105120 Moscow, Russian Federation., Thibeault C; Charite Universitaetsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine Berlin, DE 10117, Germany., Müller M; Department of Cardiology, Charite Universitaetsmedizin Berlin, DE 12203, Germany., Patriki D; Kantonsspital Baden AG, Department of Medicine, Baden, CH 5404, Switzerland., Quedenau C; Max Delbrueck Center for Molecular Medicine Berlin, DE 13125, Germany., Krüger U; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Core Unit Genomics Berlin, DE 10178, Germany., Ilinsky V; Genotek Ltd., Nastavnicheskii pereulok 17/1, R 105120 Moscow, Russian Federation., Popov I; Genotek Ltd., Nastavnicheskii pereulok 17/1, R 105120 Moscow, Russian Federation., Balnis J; Department of Molecular and Cellular Physiology, Albany Medical College, NY, USA., Jaitovich A; Department of Molecular and Cellular Physiology, Albany Medical College, NY, USA., Helbig ET; Charite Universitaetsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine Berlin, DE 10117, Germany., Lippert LJ; Charite Universitaetsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine Berlin, DE 10117, Germany., Stubbemann P; Charite Universitaetsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine Berlin, DE 10117, Germany., Real LM; Unidad Clínica de Enfermedades Infecciosas y Microbiología. Hospital Universitario de Valme, Sevilla, ES 41014, Spain., Macías J; Unidad Clínica de Enfermedades Infecciosas y Microbiología. Hospital Universitario de Valme, Sevilla, ES 41014, Spain., Pineda JA; Unidad Clínica de Enfermedades Infecciosas y Microbiología. Hospital Universitario de Valme, Sevilla, ES 41014, Spain., Fernandez-Fuertes M; Unidad Clínica de Enfermedades Infecciosas y Microbiología. Hospital Universitario de Valme, Sevilla, ES 41014, Spain., Wang X; Department of Cardiology, Charite Universitaetsmedizin Berlin, DE 12203, Germany., Karadeniz Z; Department of Cardiology, Charite Universitaetsmedizin Berlin, DE 12203, Germany., Saccomanno J; Charite Universitaetsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine Berlin, DE 10117, Germany., Doehn JM; Charite Universitaetsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine Berlin, DE 10117, Germany., Hübner RH; Charite Universitaetsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine Berlin, DE 10117, Germany., Hinzmann B; Roche Sequencing Solutions Pleasanton, USA 94588., Salvo M; Roche Sequencing Solutions Pleasanton, USA 94588., Blueher A; Roche Sequencing Solutions Pleasanton, USA 94588., Siemann S; Roche Sequencing Solutions Pleasanton, USA 94588., Jurisic S; Kantonsspital Baden AG, Department of Medicine, Baden, CH 5404, Switzerland., Beer JH; Kantonsspital Baden AG, Department of Medicine, Baden, CH 5404, Switzerland., Rutishauser J; Kantonsspital Baden AG, Department of Medicine, Baden, CH 5404, Switzerland., Wiggli B; Kantonsspital Baden AG, Department of Medicine, Baden, CH 5404, Switzerland., Schmid H; Kantonsspital Baden AG, Department of Medicine, Baden, CH 5404, Switzerland., Danninger K; Department of Cardiology and Intensive Care, Klinikum Wels-Grieskirchen, Wels, Austria., Binder R; Department of Cardiology and Intensive Care, Klinikum Wels-Grieskirchen, Wels, Austria., Corman VM; Charite Universitaetsmedizin Berlin, Institute of Virology Chariteplatz, 1 d-10117, Berlin, DE, 10117, Germany., Mühlemann B; Charite Universitaetsmedizin Berlin, Institute of Virology Chariteplatz, 1 d-10117, Berlin, DE, 10117, Germany., Arjun Arkal R; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; CoLabs, University of California San Francisco, San Francisco, CA, USA.; Department of Pathology, University of California, San Francisco, CA, USA., Fragiadakis GK; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; CoLabs, University of California San Francisco, San Francisco, CA, USA.; Division of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Mick E; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California, San Francisco, CA, USA.; Division of Infectious Diseases, University of California, San Francisco, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA., Comet C; COMET (COVID-19 Multiphenotyping for Effective Therapies) Consortium members are listed in the Supplementary Appendix 1., Calfee CS; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California, San Francisco, CA, USA., Erle DJ; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; CoLabs, University of California San Francisco, San Francisco, CA, USA.; Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA.; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California, San Francisco, CA, USA.; COMET (COVID-19 Multiphenotyping for Effective Therapies) Consortium members are listed in the Supplementary Appendix 1.; Lung Biology Center, University of California, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, CA, USA., Hendrickson CM; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California, San Francisco, CA, USA., Kangelaris KN; Department of Medicine, University of California, San Francisco, CA, USA., Krummel MF; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; Department of Pathology, University of California, San Francisco, CA, USA., Woodruff PG; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California, San Francisco, CA, USA.; Department of Pathology, University of California, San Francisco, CA, USA.; Sandler Asthma Basic Research Center, University of California, San Francisco, CA, USA., Langelier CR; Division of Infectious Diseases, University of California, San Francisco, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA., Venkataramani U; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; CoLabs, University of California San Francisco, San Francisco, CA, USA., García F; Hospital Universitario Clínico San Cecilio, Instituto de Investigación Ibs. Granada, Spain., Zyla J; Department of Data Science and Engineering, Silesian University of Technology, Gliwice, Poland., Drosten C; Charite Universitaetsmedizin Berlin, Institute of Virology Chariteplatz, 1 d-10117, Berlin, DE, 10117, Germany., Alice B; Charite Universitaetsmedizin Berlin, Dept. of Psychiatry and Psychotherapy Chariteplatz 1 d-10117 Berlin, DE 10117, Germany., Jones TC; Charite Universitaetsmedizin Berlin, Institute of Virology Chariteplatz, 1 d-10117, Berlin, DE, 10117, Germany.; German Center for Infection Research (DZIF), Associated Partner Site, 10117 Berlin, Germany.; Centre for Pathogen Evolution, Department of Zoology, University of Cambridge, Downing St., Cambridge, CB2 3EJ, U.K., Suttorp N; Charite Universitaetsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine Berlin, DE 10117, Germany., Witzenrath M; Charite Universitaetsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine Berlin, DE 10117, Germany., Hippenstiel S; Charite Universitaetsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine Berlin, DE 10117, Germany., Zemojtel T; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Core Unit Genomics Berlin, DE 10178, Germany., Skurk C; Department of Cardiology, Charite Universitaetsmedizin Berlin, DE 12203, Germany., Poller W; Department of Cardiology, Charite Universitaetsmedizin Berlin, DE 12203, Germany., Borodina T; Max Delbrueck Center for Molecular Medicine Berlin, DE 13125, Germany., Pa-Covid SG; Pa-COVID Study Group, Members are listed in the Supplementary Appendix 2., Ripke S; Charite Universitaetsmedizin Berlin, Dept. of Psychiatry and Psychotherapy Chariteplatz 1 d-10117 Berlin, DE 10117, Germany.; Massachusetts General Hospital, Analytic and Translational Genetics, Boston, MA 02114, USA.; Stanley Center for Psychiatry Research, Broad Institute of MIT and Harvard Cambridge MA 02142, USA., Sander LE; Charite Universitaetsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine Berlin, DE 10117, Germany., Beule D; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Core Unit Bioinformatics Berlin, DE 10178, Germany., Landmesser U; Department of Cardiology, Charite Universitaetsmedizin Berlin, DE 12203, Germany.; Berlin Institute of Health at Charité, Berlin, Germany., Guettouche T; Roche Sequencing Solutions Pleasanton, USA 94588., Kurth F; Charite Universitaetsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine Berlin, DE 10117, Germany., Heidecker B; Department of Cardiology, Charite Universitaetsmedizin Berlin, DE 12203, Germany.

Publikováno v: EClinicalMedicine [EClinicalMedicine] 2021 Oct; Vol. 40, pp. 101099. Date of Electronic Publication: 2021 Sep 02.