Výsledky vyhledávání - "Arjo P Rutten"

Akademický článek

Leukemic stem cell frequency: a strong biomarker for clinical outcome in acute myeloid leukemia.

Autor: Monique Terwijn, Wendelien Zeijlemaker, Angèle Kelder, Arjo P Rutten, Alexander N Snel, Willemijn J Scholten, Thomas Pabst, Gregor Verhoef, Bob Löwenberg, Sonja Zweegman, Gert J Ossenkoppele, Gerrit J Schuurhuis

Publikováno v: PLoS ONE, Vol 9, Iss 9, p e107587 (2014)

INTRODUCTION: Treatment failure in acute myeloid leukemia is probably caused by the presence of leukemia initiating cells, also referred to as leukemic stem cells, at diagnosis and their persistence after therapy. Specific identification of leukemia

Externí odkaz: https://doaj.org/article/bb974fdece6b43cb9075d0b0351d519f

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Supplementary Table 5 from Attenuation of microRNA-126 Expression That Drives CD34+38− Stem/Progenitor Cells in Acute Myeloid Leukemia Leads to Tumor Eradication

Autor: Linda Smit, Gert J. Ossenkoppele, Gerrit Jan Schuurhuis, Walter Pouwels, Arjo P. Rutten, Marjolein C. Olthof, Fedor Denkers, David C. de Leeuw

XLSX file - 54KB, Genes correlated with microRNA-126 expression in 163 AML patients show overlap with stem cell genes: Genes positively and negatively associated with miR-126 expression in 163 AML patients as published by (34). 854 genes were signifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0be0071c09a534453e4a690227defec8
https://doi.org/10.1158/0008-5472.22400873

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Supplementary Table 3 from Attenuation of microRNA-126 Expression That Drives CD34+38− Stem/Progenitor Cells in Acute Myeloid Leukemia Leads to Tumor Eradication

Autor: Linda Smit, Gert J. Ossenkoppele, Gerrit Jan Schuurhuis, Walter Pouwels, Arjo P. Rutten, Marjolein C. Olthof, Fedor Denkers, David C. de Leeuw

XLSX file - 15KB, MicroRNAs differentially expressed between LSC and HSC (at least 2 out of 3 patients): Upper: MicroRNA expression ratios between CD34+CD38-ALDHlow/dim(LSC) and CD34+CD38-ALDHhigh (HSC) populations obtained from microarray analysis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::205a160304b367da8233636005be81c1
https://doi.org/10.1158/0008-5472.22400879.v1

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Supplementary Figure 1 from Attenuation of microRNA-126 Expression That Drives CD34+38− Stem/Progenitor Cells in Acute Myeloid Leukemia Leads to Tumor Eradication

Autor: Linda Smit, Gert J. Ossenkoppele, Gerrit Jan Schuurhuis, Walter Pouwels, Arjo P. Rutten, Marjolein C. Olthof, Fedor Denkers, David C. de Leeuw

PDF file - 93KB, Validation of microarray by qRT-PCR: Surplus RNA from LSC and progenitor populations that remained after array hybridization was used for the validation of the microarray results. MicroRNA expression analysis was performed by qRT-PCR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b8e2baf628802165bd4cdb64bef018
https://doi.org/10.1158/0008-5472.22400888.v1

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Data from Attenuation of microRNA-126 Expression That Drives CD34+38− Stem/Progenitor Cells in Acute Myeloid Leukemia Leads to Tumor Eradication

Autor: Linda Smit, Gert J. Ossenkoppele, Gerrit Jan Schuurhuis, Walter Pouwels, Arjo P. Rutten, Marjolein C. Olthof, Fedor Denkers, David C. de Leeuw

Despite high remission rates after therapy, 60% to 70% of patients with acute myeloid leukemia (AML) do not survive 5 years after their initial diagnosis. The main cause of treatment failures may be insufficient eradication of a subpopulation of leuk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b90833b30d62cbe27366d54f5243b459
https://doi.org/10.1158/0008-5472.c.6505712

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Supplementary Table 2 from Attenuation of microRNA-126 Expression That Drives CD34+38− Stem/Progenitor Cells in Acute Myeloid Leukemia Leads to Tumor Eradication

Autor: Linda Smit, Gert J. Ossenkoppele, Gerrit Jan Schuurhuis, Walter Pouwels, Arjo P. Rutten, Marjolein C. Olthof, Fedor Denkers, David C. de Leeuw

XLSX file - 14KB, MicroRNAs differentially expressed between LSC and progenitors (at least 4 out of 6 patients): Upper: MicroRNA expression ratios between CD34+CD38-ALDHlow/dim (LSC) and CD34+CD38+ALDHlow/dim (malignant progenitor) populations obtain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019666fb44cfba1d1cbae8ef5b62b192
https://doi.org/10.1158/0008-5472.22400882

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Supplementary Table 4 from Attenuation of microRNA-126 Expression That Drives CD34+38− Stem/Progenitor Cells in Acute Myeloid Leukemia Leads to Tumor Eradication

Autor: Linda Smit, Gert J. Ossenkoppele, Gerrit Jan Schuurhuis, Walter Pouwels, Arjo P. Rutten, Marjolein C. Olthof, Fedor Denkers, David C. de Leeuw

XLSX file - 11KB, MicroRNA-126 is highly expressed in core binding factor AML: qRT-PCR results of miR-126 in CD34+CD38-ALDHlow/dim LSC and CD34+CD38+ALDHlow/dim leukemic progenitors in 18 AML patients. Cytogenetics indicates the presence of a CBF kar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0289ab5a2574ac15e921379c7d167de7
https://doi.org/10.1158/0008-5472.22400876

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Supplementary Table 1 from Attenuation of microRNA-126 Expression That Drives CD34+38− Stem/Progenitor Cells in Acute Myeloid Leukemia Leads to Tumor Eradication

Autor: Linda Smit, Gert J. Ossenkoppele, Gerrit Jan Schuurhuis, Walter Pouwels, Arjo P. Rutten, Marjolein C. Olthof, Fedor Denkers, David C. de Leeuw

XLSX file - 9KB, Patient characteristics and stem cell frequencies: Patient characteristics and stem cell frequencies of samples used for miRNA expression profiling using microarray. Molecular aberrancy indicates the aberrancy as detected by routine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2737060d34c085bd0b4b222574dbc027
https://doi.org/10.1158/0008-5472.22400885.v1

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Insulin-like Growth Factor Binding Protein 7 Activates the Retinoid Acid Differentiation Pathway in Acute Myeloid Leukemia Cells

Autor: Noortje van Gils, Han J.M.P. Verhagen, Linda Smit, Jeroen Janssen, Arjo P Rutten, Fedor Denkers, Esmee Dekens, Gert J. Ossenkoppele, Mei-Ling Tsui, Eline Vermue, Renee X. de Menezes

Publikováno v: Van Gils, N, Verhagen, H J M P, Rutten, A, Menezes, R X, Tsui, M-L, Dekens, E, Denkers, F, Vermue, E, Janssen, J J W M, Ossenkoppele, G J & Smit, L 2018, ' Insulin-like Growth Factor Binding Protein 7 Activates the Retinoid Acid Differentiation Pathway in Acute Myeloid Leukemia Cells ', Blood, vol. 132, no. Suppl 1 . https://doi.org/10.1182/blood-2018-99-115858
Blood, 132(Suppl 1). American Society of Hematology

Acute myeloid leukemia (AML) is characterized by the accumulation of malignant blasts with impaired transcriptional differentiation programs. Despite important advances in AML therapy, the five-year overall survival rate of AML patients remains a dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc60c29fa1ae0dfa35f110094d5e9bba
https://doi.org/10.1182/blood-2018-99-115858

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Abstract 1114: IGFBP7 reduces acute myeloid leukemia stem cell survival without affecting normal hematopoiesis

Autor: Eline Vermue, Margaretha G. M. Roemer, Renee X. de Menezes, Fabio Brocco, Mei-Ling Tsui, Gert J. Ossenkoppele, Louise L.E. de Vos Klootwijk, Meyram Cil, Marjon A. Smit, Fedor Denkers, Han J.M.P. Verhagen, Sonja Zweegman, Stan Heukelom, Noortje van Gils, Arjo P Rutten, Anna van Rhenen, Linda Smit, Gerrit Jan Schuurhuis, Jeroen Janssen

Publikováno v: Cancer Research, 78(13 Supplement), 1114-1114. American Association for Cancer Research Inc.
Cil, M, Vermue, E, Zweegman, S, Smit, M, Schuurhuis, G J, Klootwijk, L L D V, Menezes, R X, Tsui, M-L, Smit, L, Rutten, A, Gils, N V, Brocco, F, Roemer, M G, Ossenkoppele, G J, Verhagen, H J, Rhenen, A V, Janssen, J J, Denkers, F & Heukelom, S 2018, ' Abstract 1114: IGFBP7 reduces acute myeloid leukemia stem cell survival without affecting normal hematopoiesis ', Cancer Research, vol. 78, no. 13 Supplement, pp. 1114-1114 . https://doi.org/10.1158/1538-7445.am2018-1114

Only 30-40% of acute myeloid leukemia (AML) patients survive five years after diagnosis. This poor prognosis is mainly caused by treatment failure due to chemotherapy resistance and relapse. Leukemic stem cells (LSCs) are thought to be the major dete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d74fd79b27d4c2c4fcd78e51b85b1a9d
https://research.vumc.nl/en/publications/1814fe13-a507-41db-9ad8-11ca4feed46c

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