Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Arjang Talattof"'
Autor:
Duxin Sun, Bo Wen, Bart Hens, Jianghong Fan, Gregory E. Amidon, Joseph Dickens, Allen Lee, Gail Benninghoff, Marival Bermejo, Gordon L. Amidon, Jeffrey Wysocki, Paulo Paixão, Raimar Löbenberg, William L. Hasler, Arjang Talattof, Niloufar Salehi, Jason Baker, Alex Yu, Robert Lionberger, Yasuhiro Tsume, Ann Frances, Mark J. Koenigsknecht, Kerby Shedden
Publikováno v:
Mol Pharm
Exploring the intraluminal behavior of an oral drug product in the human gastrointestinal (GI) tract remains challenging. Many in vivo techniques are available to investigate the impact of GI physiology on oral drug behavior in fasting state conditio
Autor:
Gerald B. Kasting, Sam G. Raney, Priyanka Ghosh, S. Kevin Li, Qian Zhang, Terri D. La Count, Kaushalkumar Dave, Michael Murawsky, Arjang Talattof, Jinsong Hao
Publikováno v:
AAPS J
A combined experimental and computational model approach was developed to assess heat effects on drug delivery from transdermal delivery systems (TDSs) in vitro and nicotine was the model drug. A Franz diffusion cell system was modified to allow clos
Autor:
Gerald B. Kasting, Sam G. Raney, Priyanka Ghosh, Jinsong Hao, Terri D. LaCount, Arjang Talattof, S. Kevin Li, Qian Zhang
Publikováno v:
AAPS J
A computational model was developed to better understand the impact of elevated skin temperatures on transdermal drug delivery and dermal clearance. A simultaneous heat and mass transport model with emphasis on transdermal delivery system (TDS) appli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c3b2ea3a11afa9775120fd87f7b4edc
https://europepmc.org/articles/PMC7644225/
https://europepmc.org/articles/PMC7644225/
Autor:
Luca Marciani, Gregory E. Amidon, Joseph Dickens, Paulo Paixão, Duxin Sun, Alex Yu, Gordon L. Amidon, Yasuhiro Tsume, Hans Lennernäs, Kai Wang, Niloufar Salehi, Bart Hens, Kerby Shedden, William L. Hasler, Arjang Talattof, Robert M. Ziff, Jozef Al-Gousous, Marival Bermejo, Peter Langguth, Raimar Löbenberg, James G. Brasseur, Gail Benninghoff
Publikováno v:
Dissolution Technologies. 25:50-53
Summary of the In Vivo Predictive Dissolution (iPD) - Oral Drug Delivery (ODD) Conference 2018
Autor:
Tim Vanuytsel, Gordon L. Amidon, Clive G. Wilson, Jan Tack, Luca Marciani, Bart Hens, Roelof J. Bennink, Mirko Koziolek, Maura Corsetti, Joachim Brouwers, Werner Weitschies, Patrick Augustijns, Arjang Talattof, Robin C. Spiller
Publikováno v:
International journal of pharmaceutics. 519(1-2):79-97
Various gastrointestinal (GI) factors affect drug and formulation behavior after oral administration, including GI transfer, motility, pH and GI fluid volume and composition. An in-depth understanding of these physiological and anatomical variables i
Autor:
Yasuhiro Tsume, William L. Hasler, Gail Benninghoff, Paulo Paixão, Gordon L. Amidon, Gregory E. Amidon, Joseph Dickens, Duxin Sun, Bo Wen, Naír Rodríguez-Hornedo, Allen Lee, Jianghong Fan, Raimar Löbenberg, Marival Bermejo, Jason Baker, Katie L. Cavanagh, Kerby Shedden, Niloufar Salehi, Alex Yu, Arjang Talattof, Mark J. Koenigsknecht, Ann Frances, Gislaine Kuminek, Robert Lionberger, Bart Hens, Jeffrey Wysocki
Publikováno v:
Mol Pharm
The goal of this project was to explore and to statistically evaluate the responsible gastrointestinal (GI) factors that are significant factors in explaining the systemic exposure of ibuprofen, between and within human subjects. In a previous study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1f8941f706f1fba91a3eab29c093bb9
https://lirias.kuleuven.be/handle/123456789/647959
https://lirias.kuleuven.be/handle/123456789/647959
Autor:
Gordon L. Amidon, Bart Hens, Gail Benninghoff, Jozef Al-Gousous, Duxin Sun, Yasuhiro Tsume, William L. Hasler, Hans Lennernäs, Patrick D. Sinko, Arjang Talattof, Paulo Paixão, Alex Yu, James G. Brasseur, Meagan Dean, Luca Marciani, Gregory E. Amidon, Joseph Dickens, Kerby Shedden, Robert M. Ziff, Nicholas Job, Niloufar Salehi, Marival Bermejo, Peter Langguth
Publikováno v:
Int J Pharm
Over the past decade, formulation predictive dissolution (fPD) testing has gained increasing attention. Another mindset is pushed forward where scientists in our field are more confident to explore the in vivo behavior of an oral drug product by perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e1e374101cfeaeedc293ed4015d7050
Autor:
William L. Hasler, Ann Frances, Gregory E. Amidon, Joseph Dickens, Alex Yu, Jeffrey Wysocki, Paulo Paixão, Jianghong Fan, Bo Wen, Gail Benninghoff, Raimar Löbenberg, Bart Hens, Allen Lee, Marival Bermejo, Niloufar Salehi, Yasuhiro Tsume, Arjang Talattof, Robert Lionberger, Kerby Shedden, Gordon L. Amidon, Mark J. Koenigsknecht, Jason Baker, Duxin Sun
Publikováno v:
Eur J Pharm Biopharm
The goal of this study was to create a mass transport model (MTM) model for gastric emptying and upper gastrointestinal (GI) appearance that can capture the in vivo concentration-time profiles of the nonabsorbable drug phenol red in solution in the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd3544b87417b4b0f484d451483faf10
https://lirias.kuleuven.be/handle/123456789/647949
https://lirias.kuleuven.be/handle/123456789/647949
Autor:
Raimar Löbenberg, Arjang Talattof, Yasuhiro Tsume, Bart Hens, Marival Bermejo, Paulo Paixão, Gordon L. Amidon
Publikováno v:
The AAPS Journal. 20
For the last two decades, the application of physiologically based pharmacokinetic (PBPK) models has grown exponentially in the field of oral absorption and in a regulatory context. Although these models are widely used, their predictive power should
Autor:
Gordon L. Amidon, Arjang Talattof
Publikováno v:
Molecular pharmaceutics. 15(6)
Fasted-state gastrointestinal (GI) fluid transit is typically represented as a first-order, deterministic process (averaged and viewed as a continuous approximation). It is, however, most likely a discrete process involving fluid packets interrupted