Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Arjan Lankester"'
Autor:
Valentina Vavassori, Elisabetta Mercuri, Genni E Marcovecchio, Maria C Castiello, Giulia Schiroli, Luisa Albano, Carrie Margulies, Frank Buquicchio, Elena Fontana, Stefano Beretta, Ivan Merelli, Andrea Cappelleri, Paola MV Rancoita, Vassilios Lougaris, Alessandro Plebani, Maria Kanariou, Arjan Lankester, Francesca Ferrua, Eugenio Scanziani, Cecilia Cotta‐Ramusino, Anna Villa, Luigi Naldini, Pietro Genovese
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 3, Pp 1-25 (2021)
Abstract Precise correction of the CD40LG gene in T cells and hematopoietic stem/progenitor cells (HSPC) holds promise for treating X‐linked hyper‐IgM Syndrome (HIGM1), but its actual therapeutic potential remains elusive. Here, we developed a on
Externí odkaz:
https://doaj.org/article/9aef4eba41804327af789ffa8b24647a
Autor:
Laura Garcia-Perez, Marja van Eggermond, Lieke van Roon, Sandra A. Vloemans, Martijn Cordes, Axel Schambach, Michael Rothe, Dagmar Berghuis, Chantal Lagresle-Peyrou, Marina Cavazzana, Fang Zhang, Adrian J. Thrasher, Daniela Salvatori, Pauline Meij, Anna Villa, Jacques J.M. Van Dongen, Jaap-Jan Zwaginga, Mirjam van der Burg, H. Bobby Gaspar, Arjan Lankester, Frank J.T. Staal, Karin Pike-Overzet
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 666-682 (2020)
Recombinase-activating gene-1 (RAG1)-deficient severe combined immunodeficiency (SCID) patients lack B and T lymphocytes due to the inability to rearrange immunoglobulin and T cell receptor genes. Gene therapy is an alternative for those RAG1-SCID pa
Externí odkaz:
https://doaj.org/article/054d2c31c1974fd68ef81093f23e0c9c
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2021)
Hematopoietic stem cell transplantation decision-making for hemoglobinopathy patients is a complex process, and it remains difficult for health care professionals to decide whether and when a hematopoietic stem cell transplantation should be offered.
Externí odkaz:
https://doaj.org/article/62a2a2ffb9214ce491f809a5f1beddf0
Autor:
Peter Bader, Emilia Salzmann-Manrique, Adriana Balduzzi, Jean-Hugues Dalle, Ann E. Woolfrey, Merav Bar, Michael R. Verneris, Michael J. Borowitz, Nirali N. Shah, Nathan Gossai, Peter J. Shaw, Allen R. Chen, Kirk R. Schultz, Hermann Kreyenberg, Lucia Di Maio, Gianni Cazzaniga, Cornelia Eckert, Vincent H.J. van der Velden, Rosemary Sutton, Arjan Lankester, Christina Peters, Thomas E. Klingebiel, Andre M. Willasch, Stephan A. Grupp, Michael A. Pulsipher
Publikováno v:
Blood Advances, Vol 3, Iss 21, Pp 3393-3405 (2019)
Abstract: Detection of minimal residual disease (MRD) pre– and post–hematopoietic cell transplantation (HCT) for pediatric acute lymphoblastic leukemia (ALL) has been associated with relapse and poor survival. Published studies have had insuffici
Externí odkaz:
https://doaj.org/article/53bb75b719364b6dba97e0eeac5290e5
Autor:
Stefanie Klaver-Flores, Hidde A. Zittersteijn, Kirsten Canté-Barrett, Arjan Lankester, Rob C. Hoeben, Manuel A. F. V. Gonçalves, Karin Pike-Overzet, Frank J. T. Staal
Publikováno v:
Frontiers in Genome Editing, Vol 2 (2021)
Many gene editing techniques are developed and tested, yet, most of these are optimized for transformed cell lines, which differ from their primary cell counterparts in terms of transfectability, cell death propensity, differentiation capability, and
Externí odkaz:
https://doaj.org/article/7a6d9e16d2b64173a90841ea44ea4661
Publikováno v:
Frontiers in Pediatrics, Vol 7 (2019)
The field of primary immunodeficiencies has pioneered many of the advances in haematopoietic stem cell transplantation and cellular therapies over the last 50 years. The first patients to demonstrate sustained benefit and prolonged cure from the prim
Externí odkaz:
https://doaj.org/article/fc427377dd834fa4a4397aecc58541b4
Autor:
Andrew R. Gennery, Arjan Lankester, Inborn Errors Working Party (IEWP) of the European Society for Blood and Marrow Transplantation (EBMT)
Publikováno v:
Frontiers in Pediatrics, Vol 7 (2019)
Transplantation techniques for patients with primary immunodeficiencies have improved so that survival from the procedure in many cases is >80%. However, long term complications may arise due to the use or not of conditioning agents. This may result
Externí odkaz:
https://doaj.org/article/1c77527c614e431cb137750911de58c1
Autor:
Raffaella Greco, Myriam Labopin, Manuela Badoglio, Paul Veys, Juliana M. Furtado Silva, Mario Abinun, Francesca Gualandi, Martin Bornhauser, Fabio Ciceri, Riccardo Saccardi, Arjan Lankester, Tobias Alexander, Andrew R. Gennery, Peter Bader, Dominique Farge, John A. Snowden
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Background: This retrospective study assessed the use and long-term outcome of allogeneic hematopoietic stem cell transplantation (HSCT) in patients with severe autoimmune diseases (ADs), reported to the European Society for Blood and Marrow Transpla
Externí odkaz:
https://doaj.org/article/4a673956c589482d87377aad1cf83211
Autor:
Laura Garcia-Perez, Anita Ordas, Kirsten Canté-Barrett, Pauline Meij, Karin Pike-Overzet, Arjan Lankester, Frank J. T. Staal
Publikováno v:
Pharmaceutics, Vol 12, Iss 6, p 549 (2020)
Recent clinical trials using patient’s own corrected hematopoietic stem cells (HSCs), such as for primary immunodeficiencies (Adenosine deaminase (ADA) deficiency, X-linked Severe Combined Immunodeficiency (SCID), X-linked chronic granulomatous dis
Externí odkaz:
https://doaj.org/article/f7384b59646643259df56c913fa8ae80
Autor:
Suzanna M. van Walraven, Anneke Brand, Jack N.A. Bakker, Martin B.A. Heemskerk, Suzan Nillesen, Marc B. Bierings, Laura B. Bungener, Bouke G. Hepkema, Arjan Lankester, Arnold van der Meer, Kees Sintnicolaas, Judith A.E. Somers, Eric Spierings, Marcel G.J. Tilanus, Christien E.M. Voorter, Jan J. Cornelissen, Machteld Oudshoorn
Publikováno v:
Haematologica, Vol 102, Iss 1 (2017)
Between 2001 and 2012, the number of unrelated donors registered worldwide increased from 7 to 21 million, and the number of public cord blood units increased to over 500,000. We addressed the question of whether this expansion resulted in higher per
Externí odkaz:
https://doaj.org/article/2e119e2cf43042ffbdff716d1171d545