Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Arjan Lakeman"'
A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma
Autor:
Tim van Groningen, Nurdan Akogul, Ellen M. Westerhout, Alvin Chan, Nancy E. Hasselt, Danny A. Zwijnenburg, Marloes Broekmans, Peter Stroeken, Franciska Haneveld, Gerrit K. J. Hooijer, C. Dilara Savci-Heijink, Arjan Lakeman, Richard Volckmann, Peter van Sluis, Linda J. Valentijn, Jan Koster, Rogier Versteeg, Johan van Nes
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Neuroblastoma includes adrenergic and mesenchymal cell types that can interconvert. Here, the authors show that this transdifferentiation is driven by a NOTCH feedforward loop that allows a swift transition between two semi-stable cellular states.
Externí odkaz:
https://doaj.org/article/514276fb271e42e0afc3df43c40d7742
Autor:
Marcel Kool, Jan Koster, Jens Bunt, Nancy E Hasselt, Arjan Lakeman, Peter van Sluis, Dirk Troost, Netteke Schouten-van Meeteren, Huib N Caron, Jacqueline Cloos, Alan Mrsić, Bauke Ylstra, Wieslawa Grajkowska, Wolfgang Hartmann, Torsten Pietsch, David Ellison, Steven C Clifford, Rogier Versteeg
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e3088 (2008)
BackgroundMedulloblastoma is the most common malignant brain tumor in children. Despite recent improvements in cure rates, prediction of disease outcome remains a major challenge and survivors suffer from serious therapy-related side-effects. Recent
Externí odkaz:
https://doaj.org/article/85a9aa46f4a043bb939c4550eb28e806
Autor:
Frank Speleman, Rogier Versteeg, Jan Cools, Angelika Eggert, Huib Caron, Miki Ohira, Akira Nakagawara, Tommy Martinsson, Per Kogner, Isabelle Janoueix-Lerosey, Olivier Delattre, Rosa Noguera, Marleen Renard, Klaus Beiske, Nadine Van Roy, Joëlle Vermeulen, Caroline Van Den Broecke, Alexander Schramm, Johannes H. Schulte, Geneviève Laureys, Anne De Paepe, Tom Van Maerken, Jasmien Hoebeeck, Jo Vandesompele, Arjan Lakeman, Ellen M. Westerhout, Michaël Porcu, Piotr Zabrocki, Candy Kumps, Katleen De Preter, Sara De Brouwer
PDF file - 1.29MB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82107809a8b7b9376db08ebd380298f
https://doi.org/10.1158/1078-0432.22440859.v1
https://doi.org/10.1158/1078-0432.22440859.v1
Autor:
Rogier Versteeg, Johan van Nes, Linda J. Valentijn, Jan Koster, Tim van Groningen, Igor Adameyko, Carel J.M. van Noesel, Richard Volckmann, Danny Zwijnenburg, Peter van Sluis, Alvin Chan, Franciska Haneveld, Nurdan Akogul, Boris Bleijlevens, Nancy E. Hasselt, Jennemiek van Arkel, Arjan Lakeman, Natalia E. Nowakowska, Peter Stroeken, Mohamed Hamdi, Ellen M. Westerhout
Supplementary Data from Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f14876aaaa2f25f4335b62b0c96a3c
https://doi.org/10.1158/0008-5472.22430725.v1
https://doi.org/10.1158/0008-5472.22430725.v1
Autor:
Frank Speleman, Rogier Versteeg, Jan Cools, Angelika Eggert, Huib Caron, Miki Ohira, Akira Nakagawara, Tommy Martinsson, Per Kogner, Isabelle Janoueix-Lerosey, Olivier Delattre, Rosa Noguera, Marleen Renard, Klaus Beiske, Nadine Van Roy, Joëlle Vermeulen, Caroline Van Den Broecke, Alexander Schramm, Johannes H. Schulte, Geneviève Laureys, Anne De Paepe, Tom Van Maerken, Jasmien Hoebeeck, Jo Vandesompele, Arjan Lakeman, Ellen M. Westerhout, Michaël Porcu, Piotr Zabrocki, Candy Kumps, Katleen De Preter, Sara De Brouwer
Purpose: Activating mutations of the anaplastic lymphoma kinase (ALK) were recently described in neuroblastoma. We carried out a meta-analysis of 709 neuroblastoma tumors to determine their frequency and mutation spectrum in relation to genomic and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22eda6bf8d9c14bdd864788a994a7ed0
https://doi.org/10.1158/1078-0432.c.6518119
https://doi.org/10.1158/1078-0432.c.6518119
Autor:
Frank Speleman, Rogier Versteeg, Jan Cools, Angelika Eggert, Huib Caron, Miki Ohira, Akira Nakagawara, Tommy Martinsson, Per Kogner, Isabelle Janoueix-Lerosey, Olivier Delattre, Rosa Noguera, Marleen Renard, Klaus Beiske, Nadine Van Roy, Joëlle Vermeulen, Caroline Van Den Broecke, Alexander Schramm, Johannes H. Schulte, Geneviève Laureys, Anne De Paepe, Tom Van Maerken, Jasmien Hoebeeck, Jo Vandesompele, Arjan Lakeman, Ellen M. Westerhout, Michaël Porcu, Piotr Zabrocki, Candy Kumps, Katleen De Preter, Sara De Brouwer
PDF file - 42K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50026863f019cf4d1ef57ff176d175bb
https://doi.org/10.1158/1078-0432.22440856
https://doi.org/10.1158/1078-0432.22440856
Autor:
Rogier Versteeg, Johan van Nes, Linda J. Valentijn, Jan Koster, Tim van Groningen, Igor Adameyko, Carel J.M. van Noesel, Richard Volckmann, Danny Zwijnenburg, Peter van Sluis, Alvin Chan, Franciska Haneveld, Nurdan Akogul, Boris Bleijlevens, Nancy E. Hasselt, Jennemiek van Arkel, Arjan Lakeman, Natalia E. Nowakowska, Peter Stroeken, Mohamed Hamdi, Ellen M. Westerhout
Cancer therapy frequently fails due to the emergence of resistance. Many tumors include phenotypically immature tumor cells, which have been implicated in therapy resistance. Neuroblastoma cells can adopt a lineage-committed adrenergic (ADRN) or an i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b5f661dcd417faae73e178ff2f438c5
https://doi.org/10.1158/0008-5472.c.6513703.v1
https://doi.org/10.1158/0008-5472.c.6513703.v1
Autor:
Marcel Kool, Rogier Versteeg, Dirk Geerts, Arjan Lakeman, Danny Zwijnenburg, Mohamed Hamdi, Gerben Schaaf
Supplementary Figure 4 from Silencing of SPRY1 Triggers Complete Regression of Rhabdomyosarcoma Tumors Carrying a Mutated RAS Gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::470364d4ebc5cca2c6d3f613384d5f0f
https://doi.org/10.1158/0008-5472.22383809.v1
https://doi.org/10.1158/0008-5472.22383809.v1
Autor:
Marcel Kool, Rogier Versteeg, Dirk Geerts, Arjan Lakeman, Danny Zwijnenburg, Mohamed Hamdi, Gerben Schaaf
Supplementary Figure 1 from Silencing of SPRY1 Triggers Complete Regression of Rhabdomyosarcoma Tumors Carrying a Mutated RAS Gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8d9b7dab9e44612e3fe1b8d7ccd798
https://doi.org/10.1158/0008-5472.22383821.v1
https://doi.org/10.1158/0008-5472.22383821.v1
Autor:
Marcel Kool, Rogier Versteeg, Dirk Geerts, Arjan Lakeman, Danny Zwijnenburg, Mohamed Hamdi, Gerben Schaaf
RAS oncogenes are among the most frequently mutated genes in human cancer, but effective strategies for therapeutic inhibition of the RAS pathway have been elusive. Sprouty1 (SPRY1) is an upstream antagonist of RAS that is activated by extracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0725b87fee11e2cd0ec8d83d622fb8b
https://doi.org/10.1158/0008-5472.c.6500663
https://doi.org/10.1158/0008-5472.c.6500663