Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Arjan J. Groot"'
Autor:
Lorena Giuranno, Eloy M. Roig, Carolien Wansleeben, Annette van denBerg, Arjan J. Groot, Ludwig Dubois, Marc Vooijs
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 7, Pp 799-812 (2020)
Abstract Hyperactivity of the NOTCH pathway is associated with tumor growth and radiotherapy resistance in lung cancer, and NOTCH/γ‐secretase inhibitors (GSIs) are a potential therapeutic target. The therapeutic outcome, however, is often restrict
Externí odkaz:
https://doaj.org/article/5940253b822140699faa623d3186f1dc
Autor:
Ying Gong, Roel G.J. Klein Wolterink, Ian Janssen, Arjan J. Groot, Gerard M.J. Bos, Wilfred T.V. Germeraad
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 634-646 (2020)
Adoptive natural killer (NK) cell therapy is attaining promising clinical outcomes in recent years, but improvements are needed. Genetic modification of NK cells with a tumor antigen-specific receptor on their surface coupled to intracellular signali
Externí odkaz:
https://doaj.org/article/4503aa90efd24745b4f20473c1698b88
Autor:
Jenny A. F. Vermeer, Jonathan Ient, Bostjan Markelc, Jakob Kaeppler, Lydie M. O. Barbeau, Arjan J. Groot, Ruth J. Muschel, Marc A. Vooijs
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 7 (2020)
Intratumoural hypoxia is a common characteristic of malignant treatment-resistant cancers. However, hypoxia-modification strategies for the clinic remain elusive. To date, little is known on the behaviour of individual hypoxic tumour cells in their m
Externí odkaz:
https://doaj.org/article/06c80dc265d14a17aca588930a6cf945
Autor:
Venus Sosa Iglesias, Jan Theys, Arjan J. Groot, Lydie M. O. Barbeau, Alyssa Lemmens, Ala Yaromina, Mario Losen, Ruud Houben, Ludwig Dubois, Marc Vooijs
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
Background: Lung cancer is the leading cause of cancer death worldwide. More effective treatments are needed to increase durable responses and prolong patient survival. Standard of care treatment for patients with non-operable stage III-IV NSCLC is c
Externí odkaz:
https://doaj.org/article/0220edbc70dd4d41a14051264307e964
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
Hypoxia-inducible factor-2α (HIF-2α) plays an important role in tumor progression and metastasis. A number of studies have evaluated the correlation between HIF-2α overexpression and clinical outcome in cancer patients but yielded inconsistent res
Externí odkaz:
https://doaj.org/article/c85e4c4e698c4b8f81e6cb06c8e63384
Autor:
Eloy Moreno Roig, Arjan J. Groot, Ala Yaromina, Tessa C. Hendrickx, Lydie M. O. Barbeau, Lorena Giuranno, Glenn Dams, Jonathan Ient, Veronica Olivo Pimentel, Marike W. van Gisbergen, Ludwig J. Dubois, Marc A. Vooijs
Publikováno v:
Cells, Vol 8, Iss 1, p 45 (2019)
The hypoxia-inducible transcription factors (HIF)-1/2α are the main oxygen sensors which regulate the adaptation to intratumoral hypoxia. The aim of this study was to assess the role of the HIF proteins in regulating the radiation response of a non-
Externí odkaz:
https://doaj.org/article/a57a3bc6fa54419b86f08b433c6861ca
Publikováno v:
Cellular Oncology, Vol 30, Iss 5, Pp 397-409 (2008)
Hypoxia is a hallmark of solid cancers and triggers the transcription of genes responsible for cell survival. The transcription factor Hypoxia-Inducible Factor 1 (HIF-1) is a key regulator in this response and frequently activated in human cancer. HI
Externí odkaz:
https://doaj.org/article/5c6e3f22de65459b9fbe9a703b8de21e
Autor:
Ludwig Dubois, Marc Vooijs, Arjan J. Groot, Eloy Moreno Roig, Annette van den Berg, Carolien Wansleeben, Lorena Giuranno
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 7, Pp 799-812 (2020)
Stem Cells Translational Medicine
Stem Cells Translational Medicine, 9(7), 799-812. AlphaMed Press
Stem Cells Translational Medicine
Stem Cells Translational Medicine, 9(7), 799-812. AlphaMed Press
Hyperactivity of the NOTCH pathway is associated with tumor growth and radiotherapy resistance in lung cancer, and NOTCH/γ-secretase inhibitors (GSIs) are a potential therapeutic target. The therapeutic outcome, however, is often restricted by the d
Autor:
Marc Vooijs, Judith Hounjet, Raffaella Iannone, Arjan J. Groot, Louise Arathoon, Lorena Giuranno, Carolien Wansleeben
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology, 317(3), L414-L423. American Physiological Society
Radiation-induced lung injury to normal airway epithelium is a frequent side-effect and dose-limiting factor in radiotherapy of tumors in the thoracic cavity. NOTCH signaling plays key roles in self-renewal and differentiation of upper airway basal l
Autor:
Roger Habets, Kasper M.A. Rouschop, Judith Hounjet, Tessa C. Hendrickx, Lydie M. O. Barbeau, Marco B.E. Schaaf, Sanaz Yahyanejad, Marc Vooijs, Arjan J. Groot
Publikováno v:
Oncogene, 38(27), 5457-5468. Nature Publishing Group
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive cancer arising from T-cell progenitors. Although current treatments, including chemotherapy and glucocorticoids, have significantly improved survival, T-ALL remains a fatal disease and new