Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Aritsara Jaruwat"'
Autor:
Pimchai Chaiyen, Jirawat Tantipisit, Asweena Binlaeh, Litavadee Chuaboon, Juthamas Jaroensuk, Somchart Maenpuen, Penchit Chitnumsub, Ruchanok Tinikul, Aritsara Jaruwat, Jittima Phonbuppha, Pratchaya Watthaisong, Narin Lawan
Publikováno v:
The Journal of Biological Chemistry
Aldolases catalyze the reversible reactions of aldol condensation and cleavage and have strong potential for the synthesis of chiral compounds, widely used in pharmaceuticals. Here, we investigated a new Class II metal aldolase from the p-hydroxyphen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ec40387511a3835e3f518a5fda0050
http://europepmc.org/articles/PMC8560999
http://europepmc.org/articles/PMC8560999
Autor:
Panu Pimviriyakul, Narin Lawan, Aritsara Jaruwat, Pimchai Chaiyen, Pratchaya Watthaisong, Pornkanok Pongpamorn, Penchit Chitnumsub
Publikováno v:
ChemBioChem. 20:3020-3031
HadA is a flavin-dependent monooxygenase that can catalyze the denitration and dehalogenation of a wide variety of toxicants such as pesticides. Although these enzymatic reactions are useful for bioremediation or biocatalysis, the application of HadA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::241d3dc260baa8572adf0a13a2447d5d
https://doi.org/10.1002/cbic.201900413
https://doi.org/10.1002/cbic.201900413
Publikováno v:
The Journal of Biological Chemistry
HadA is a flavin-dependent monooxygenase catalyzing hydroxylation plus dehalogenation/denitration, which is useful for biodetoxification and biodetection. In this study, the X-ray structure of wild-type HadA (HadAWT) co-complexed with reduced FAD (FA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6a3d53189238f87d83faa47e6e4dea
https://pubmed.ncbi.nlm.nih.gov/34252455
https://pubmed.ncbi.nlm.nih.gov/34252455
Autor:
Penchit Chitnumsub, Warangkhana Songsungthong, Chadaporn Kantiwiriyawanitch, Adrian J. Mulholland, Aritsara Jaruwat, Pimchai Chaiyen, Narin Lawan, Duangthip Trisrivirat, Surawit Visitsatthawong, Kridsadakorn Prakinee, Karl-Heinz van Pée, Pirom Chenprakhon, Aisaraphon Phintha
Publikováno v:
Phintha, A, Prakinee, K, Jaruwat, A, Lawan, N, Visitsatthawong, S, Kantiwiriyawanitch, C, Songsungthong, W, Trisrivirat, D, Chenprakhon, P, Mulholland, A, van Pée, K-H, Chitnumsub, P & Chaiyen, P 2021, ' Dissecting the low catalytic capability of flavin-dependent halogenases ', Journal of Biological Chemistry, vol. 296, 100068, pp. 100068 . https://doi.org/10.1074/jbc.RA120.016004
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Although flavin-dependent halogenases (FDHs) are attractive biocatalysts, their practical applications are limited because of their low catalytic efficiency. Here, we investigated the reaction mechanisms and structures of tryptophan 6-halogenase (Tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada40f468526b9483430aa5b3b4ae747
https://hdl.handle.net/1983/abdb69bf-dfab-4177-bda5-14b7a2899da6
https://hdl.handle.net/1983/abdb69bf-dfab-4177-bda5-14b7a2899da6
Autor:
Raphael Aponte, Michelle S. Frei, Wanwipa Ittarat, Matthias Rottmann, Ubolsree Leartsakulpanich, Aritsara Jaruwat, Kerstin Mark, Penchit Chitnumsub, François Diederich, Matthias Witschel, Pimchai Chaiyen, Geoffrey Schwertz, Nils Trapp, Anja Schäfer
Publikováno v:
Chemistry - A European Journal. 23:14345-14357
Malaria remains a major threat to mankind due to the perpetual emergence of resistance against marketed drugs. Twenty-one pyrazolopyran-based inhibitors bearing terminal biphenyl, aryl sulfonamide, or aryl sulfone motifs were synthesized and tested t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022157e68cfc7829a69ef729a9f160ee
https://doi.org/10.1002/chem.201703244
https://doi.org/10.1002/chem.201703244
Autor:
Abhijit Kundu, Matthias Witschel, Marc Siggel, Pimchai Chaiyen, Wanwipa Ittarat, Anja Schäfer, Susan A. Charman, Raphael Aponte, Ubolsree Leartsakulpanich, Geoffrey Schwertz, Karen L. White, François Diederich, Aritsara Jaruwat, Gail M. Freiberg, Roger Bonnert, Adrian Zwyssig, Surajit Sadhukhan, Penchit Chitnumsub, Matthias Rottmann, Mel Lloyd, Myron Srikumaran
Publikováno v:
Journal of Medicinal Chemistry. 60:4840-4860
Target-based approaches toward new antimalarial treatments are highly valuable to prevent resistance development. We report several series of pyrazolopyran-based inhibitors targeting the enzyme serine hydroxymethyltransferase (SHMT), designed to impr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::392cac0ad516603577a9626aa1cf6733
https://doi.org/10.1021/acs.jmedchem.7b00008
https://doi.org/10.1021/acs.jmedchem.7b00008
Autor:
Penchit Chitnumsub, Sakunrat Ubonprasert, Pinpunya Riangrungroj, Aritsara Jaruwat, Udom Sae-Ueng, B. Kuaprasert, Ubolsree Leartsakulpanich, Yongyuth Yuthavong
Publikováno v:
Archives of biochemistry and biophysics. 667
Plasmodium falciparum (Pf), a malarial pathogen, can only synthesize purine nucleotides employing a salvage pathway because it lacks de novo biosynthesis. Adenosine deaminase (ADA), one of the three purine salvage enzymes, catalyzes the irreversible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3640834b1e3178eaf6b959ca7d0cd4c
https://pubmed.ncbi.nlm.nih.gov/31002765
https://pubmed.ncbi.nlm.nih.gov/31002765
Autor:
Panu Pimviriyakul1, Aritsara Jaruwat2, Penchit Chitnumsub2 penchit@biotec.or.th, Pimchai Chaiyen3 pimchai.chaiyen@vistec.ac.th
Publikováno v:
Journal of Biological Chemistry. Aug2021, Vol. 297 Issue 2, p1-17. 17p.
Autor:
Geoffrey Schwertz, Wanwipa Ittarat, Watcharee Amornwatcharapong, Nils Trapp, Matthias Rottmann, Raphael Aponte, Ubolsree Leartsakulpanich, Anja Schäfer, Aritsara Jaruwat, Matthias Witschel, Pimchai Chaiyen, François Diederich, Penchit Chitnumsub
Publikováno v:
ChemMedChem. 13(9)
With the discovery that serine hydroxymethyltransferase (SHMT) is a druggable target for antimalarials, the aim of this study was to design novel inhibitors of this key enzyme in the folate biosynthesis cycle. Herein, 19 novel spirocyclic ligands bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1801bc472255e311addd0abeeca843c1
https://pubmed.ncbi.nlm.nih.gov/29655285
https://pubmed.ncbi.nlm.nih.gov/29655285
Autor:
Thomas Mietzner, Sandro Tonazzi, Ubolsree Leartsakulpanich, Penchit Chitnumsub, Pimchai Chaiyen, Frank Thater, Sergio Wittlin, Susan A. Charman, Case W. McNamara, Michael Seet, Matthias Witschel, Matthias Hamburger, Anatol Schwab, Aritsara Jaruwat, Pascal Mäser, Mouhssin Oufir, Yongyuth Yuthavong, François Diederich, Chatchadaporn Pinthong, Frank Stelzer, Geoffrey Schwertz, Laura M. Sanz-Alonso, Pinpunya Riangrungroj, Matthias Rottmann, Céline Freymond
Publikováno v:
Journal of Medicinal Chemistry. 58:3117-3130
Several of the enzymes related to the folate cycle are well-known for their role as clinically validated antimalarial targets. Nevertheless for serine hydroxymethyltransferase (SHMT), one of the key enzymes of this cycle, efficient inhibitors have no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bdfd795a141959c2129bfef124f9036
https://doi.org/10.1021/jm501987h
https://doi.org/10.1021/jm501987h